VIOLIN: Vaccine Investigation and Online Information Network

lctP

General Information

Protegen ID

600

Sequence Strain (Species/Organism)

Neisseria meningitidis

VO ID

VO_0011185

Taxonomy ID

662598

Other Database IDs

CDD:224535
EnsemblGenomes-Gn:NMO_0425
EnsemblGenomes-Tr:CBA04244
GOA:C6S5G4
InterPro: IPR003804
UniProtKB/TrEMBL: C6S5G4

Molecule Role

Protective antigen

Molecule Role Annotation

A total of 11 meningococcal proteins that are necessary for establishing systemic infection were expressed as recombinant antigens and assessed for their ability to protect mice against live bacterial challenge against N. meningitidis; the lactate permease (LctP) elicited protective immunity (Sun et al., 2005).

Related Vaccines(s)

N. meningitidis LctP Protein Vaccine

References

Sun et al., 2005: Sun Y, Li Y, Exley RM, Winterbotham M, Ison C, Smith H, Tang CM. Identification of novel antigens that protect against systemic meningococcal infection. Vaccine. 2005; 23(32); 4136-4141. [PubMed: 15964482].

Gene Information

Gene Name

lctP

Protein Information

Protein Name

L-lactate permease

NCBI Protein GI

254667969

Protein pI

8.92

Protein Weight

52305.14

Protein Length

601

Protein Note

L-lactate permease [Energy production and conversion]; COG1620

Protein Sequence

>CBA04244.1 L-lactate permease [Neisseria meningitidis alpha14]
MALFLSIFPIVLLIWLMVKKNSMPSYVALPITAVLIYAIKLFYFGDAGMLLNATAASGLVKTLTPITVIF
GAIMFNRMMETTGCIDVIRKWLATISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILMSLGFNPLK
VAIFTLVMNSVPVSFGAVGTPTWFGFAPLNLSAEDILAIGRQTGVMHFFAGFVIPVIGLGFIVPWSEIRK
NLGFVAIAVFSCTIPYVALAMVNEEFPSLVAGAIGLMVSVFAANQGWGLSKDHAKDPNAEKVPFAQVAKA
LAPLGMLIGMLVVTRIKQLGIKGILTSKEEWFSFQLPFDLSKITVSDSLTITFGNIFGQDVSASYQTLYV
PAWIPFVLTVWICILLYKTKFKDAWTIYSVTFNQTKKPLLALMGALIMVQLMLVGGDNSMVKIIGKEFAA
MAGEHWVYFSPYLGAIGAFFSGSNTVSNLTFGPIQQQIALDTGLSVTLILALQSVGGAMGNMVCLNNIIA
VCTVLDVKNSEGAIIKKTVIPMAIYGVIAVVAAMIFFL

Epitope Information

IEDB Linear Epitope