VIOLIN: Vaccine Investigation and Online Information Network

MAG1

General Information

Protegen ID

604

Sequence Strain (Species/Organism)

Neospora caninum

VO ID

VO_0011189

Taxonomy ID

29176

Other Database IDs

CDD:274008

Molecule Role

Protective antigen

Molecule Role Annotation

Intraperitoneal application of NcMAG1 suspended in saponin adjuvants lead to protection against disease in 50% of animals vaccinated in a C57Bl/6 mouse cerebral infection model (Debache et al., 2010).

Related Vaccines(s)

N. caninum NcMAG1 Protein Vaccine

References

Debache et al., 2010: Debache K, Guionaud C, Alaeddine F, Hemphill A. Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology. 2010; 137(2); 229-240. [PubMed: 19835644].

Gene Information

Gene Name

MAG1

NCBI Gene ID

13443506

NCBI Nucleotide GI

EF580924.1

Protein Information

Protein Name

cyst matrix and cyst wall protein

NCBI Protein GI

147886433

Protein pI

5.02

Protein Weight

46643.52

Protein Length

529

Protein Note

chromosome segregation protein SMC, common bacterial type; TIGR02168

Protein Sequence

>ABQ52425.1 cyst matrix and cyst wall protein [Neospora caninum]
MAFGRGKRGLHAAVILGFFVLLATSSVGLGQRVPRYPSVESLEERVAEALGRRSSAAASTLPGSDTNMIS
DGRAGRDEPTASPEHHSVDAPTTSGEGEADAGKVTLRNDEGLEGNISADHVLHPPPDSEHEGLQEPGTTH
QEAQEPDASEAMDSSALPLSTSVPHPNEVGSTPGTALPAPIFSIPELSPEEVVYVLRVQGSGDFEISFQV
GRVVRQLEAIKRAYREAHGKLEAEELESERGPTVSTRTKLVDFIKENQRRLRAAFQKVKIQQKLEEIEEL
LQLSHALKSLGARLRPCQKSNSPMEEEICRKTKALGEMVAQKAEDLRQHASTVSALLGREAVERQLRRVD
SEQPYEQTDAGVAARAEEFRKALEKAASGARQFVGTTADEIVEEVKEDAQYLRDGAKEVLTKSQRALVDA
FQAIQRALLEAKAKELVDAASKEAEDARKILAEQPA

Epitope Information

IEDB Linear Epitope