VIOLIN: Vaccine Investigation and Online Information Network

Fbp

General Information

Protegen ID

632

Sequence Strain (Species/Organism)

Streptococcus equi subsp. equi 4047

VO ID

VO_0011216

Taxonomy ID

553482

Molecule Role

Protective antigen

Molecule Role Annotation

The fibrinogen-binding protein (FgBP) reacted with serum taken from horses recovering from strangles and protected mice against lethal challenge from S. equi subsp. equi (Meehan et al., 1998).

References

Meehan et al., 1998: Meehan M, Nowlan P, Owen P. Affinity purification and characterization of a fibrinogen-binding protein complex which protects mice against lethal challenge with Streptococcus equi subsp. equi. Microbiology (Reading, England). 1998; 144 ( Pt 4); 993-991003. [PubMed: 9579073].

Gene Information

Gene Name

Fbp

NCBI Gene ID

7697172

Genbank Accession

FM204883

Locus Tag

SEQ_2017

Gene Starting Position

2043360

Gene Ending Position

2044964

DNA Sequence

>NC_012471.1:2043360-2044964 Streptococcus equi subsp. equi 4047, complete genome
CTTAGTTTTCTTTGCGTTTAGGAGACACCACAGCCATACCAGCACCAGCGATGACAGTAAGAGCTGCAAT
AGTGAAGAATGGGTTAGCAGACTCACCAGTAGATGGCAATTGACCTGCTTTAGCAGTTGTAGTGCCTGGG
TTTGTTTGTGAAGCACGACCACCTTGTGACAATGACTTAATCCTGTCAGCTAGCTCTTGCTTCAAGCGAT
TGATTTCTGCTTGAAGATCTGCATTTGCATGGTCTTTCTTCTCAAGCATTTCTTTAAGTTTTGAAAGTTC
CTCAGCATGAGCTTTTTTGAGCTCTTCAATCTTAGCTTCAAGCGCTTCTTTTTCCTTCTTAACGGCTTCA
AGCTCTTCTTCTTTCTTAGCTAATTGTACTTTAAGATCTGCAACCTCAGCTTTAGCAGCTTCAACTTCTT
TTTCAAGCTCTGCTACCTTAGCATCTGATGCTGCTTTTTGTTTTTCAAGCTCTGCTACATTAGCTTGTGA
TTCTACTAAAGCCTTATCAGAAGCATCTTTTTGTTTTTGTAGCTCAGCAATTTCACGTTTGCCTGATTCA
ATCAAACGCTCTGAAACAGCAAGCTCTGTCTTAGCTTTTTCTAGCTCTGTTTGAAGTGATGCAATGGTGT
CATTTGCAGCTGCAAGCTCTGCATCAGCCTTAGCCTTATCAGCAGTTAATTGATCAATTTCTGCTAATTT
TTGAGCCATTTCACGTTTTGCAGACTCTACCAAGCGGTCTAGACTACCAACGTTTTCCATTAACTTTTCA
GCTTCTGCTGTTTTAGCTGCCAATTTATCTGCTAAATCTTTTGATACTGCAAAAGCTTTATCACGACTTG
CTTCAGCACTACTTAGTTTATCTGCTAAATCTTTTGATACTGCAAAGGCTTTATCACGACTTGCTTCAGC
ATTGCTTAGCTTATCTGCTAATTCCTTAGTCATCTTAGCTGCTTTTTCTTTTTCTTTTGCAAGTTCTGTT
TTTAGTTTATTATACTCTTTTGTTGATCTTGATAAAGTTTTGTTGAATGATTCGGTAAGAGCTTGACGCT
CATCTTTAGCTTTTTGTAGTTCTTGTTCTTTTTCCTTCTCTAGATTTCGAAGTTGGGAATCTCTTTCTCT
AAGCATTTCTTGTTGAGATTTAATAGCTGCAAGTTTAGCCTCAAGAAGTTTTGCATAACTATCTCCATCA
GCAATCCGCTTTTCAATTTCATCTACAAGTAATGAAGCCAAACTTAATTGTCTTCTATCCCCATCAGGTT
TATCATTTAACATCGATGAAAGGTGCACCAATAAATTGTAATAATCATCTCTACCATACGCAGCCCTTGC
TGAATCAAGACCTCTCAATAATGCCTGTAAATCCCCAACAGAGGCGCCTTTTAGAAGATTTCGAACTTTT
TGGGCTGATGAGGCATCTCTACTTATGGCTATTTCGCTTAATCTATTTTTTAAATCACGCGATAATCTTG
GAGTCGCCGTACGACTAACCTCAGAGTTCGCTTTTACAGTTGTCCCTCCCAACACACTTGTTGCAACTAA
TACTGATGCTGCACCGGCACTTAGTTTTCTGATGCTAAATTTTTGCTTGTTATTTCTCAAAAACA

Protein Information

Protein Name

antiphagocytic cell surface-anchored fibrinogen-and IgG Fc-binding protein SeM

NCBI Protein GI

225871286

Protein Accession

YP_002747233

Protein pI

9.36

Protein Weight

55929.26

Protein Length

534

Protein Note

Previously sequenced as Streptococcus equi fibrinogen-binding protein Fbp UniProt: AF012927 (534 aa" target="_blank">O68165 (EMBL: AF012927 (534 aa) blastp scores: E()=0.0

Protein Sequence

>YP_002747233.1 antiphagocytic cell surface-anchored fibrinogen-and IgG Fc-binding protein SeM [Streptococcus equi subsp. equi 4047]
MFLRNNKQKFSIRKLSAGAASVLVATSVLGGTTVKANSEVSRTATPRLSRDLKNRLSEIAISRDASSAQK
VRNLLKGASVGDLQALLRGLDSARAAYGRDDYYNLLVHLSSMLNDKPDGDRRQLSLASLLVDEIEKRIAD
GDSYAKLLEAKLAAIKSQQEMLRERDSQLRNLEKEKEQELQKAKDERQALTESFNKTLSRSTKEYNKLKT
ELAKEKEKAAKMTKELADKLSNAEASRDKAFAVSKDLADKLSSAEASRDKAFAVSKDLADKLAAKTAEAE
KLMENVGSLDRLVESAKREMAQKLAEIDQLTADKAKADAELAAANDTIASLQTELEKAKTELAVSERLIE
SGKREIAELQKQKDASDKALVESQANVAELEKQKAASDAKVAELEKEVEAAKAEVADLKVQLAKKEEELE
AVKKEKEALEAKIEELKKAHAEELSKLKEMLEKKDHANADLQAEINRLKQELADRIKSLSQGGRASQTNP
GTTTAKAGQLPSTGESANPFFTIAALTVIAGAGMAVVSPKRKEN

Epitope Information

IEDB Linear Epitope