VIOLIN: Vaccine Investigation and Online Information Network

CS from P. yoelii

General Information

Protegen ID

635

Sequence Strain (Species/Organism)

Plasmodium yoelii

VO ID

VO_0011219

Taxonomy ID

5861

Molecule Role

Protective antigen

Molecule Role Annotation

Study showed that immunization with irradiated sporozoites (IrrSpz) of a P. berghei line whose endogenous CS was replaced by that of P. yoelii conferred sterile protection against challenge with wild type P. berghei sporozoites (Mauduit et al., 2009).

Related Vaccines(s)

P. yoelii DNA vaccine pDIP/PyCSP. 1

References

Mauduit et al., 2009: Mauduit M, GrÃ¼ner AC, Tewari R, Depinay N, Kayibanda M, Chavatte JM, Franetich JF, Crisanti A, Mazier D, Snounou G, RÃ©nia L. A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites. PloS one. 2009; 4(11); e7717. [PubMed: 19890387].

Gene Information

Gene Name

CS from P. yoelii

NCBI Gene ID

3800426

Genbank Accession

LM993658

Chromosome No

Locus Tag

PY17X_0405400

Gene Starting Position

317725

Gene Ending Position

319008

Protein Information

NCBI Protein GI

1844509887

Protein Accession

XP_728216

Protein pI

4.79

Protein Weight

42077.07

Protein Length

427

Protein Sequence

>XP_728216.3 circumsporozoite protein precursor [Plasmodium yoelii]
MKKCTILVVASLLLVDSLLPGYGQNKSVQAQRNLNELCYNEENDNKLYHVLNSKNGKIYNRNIVNRLLGD
ALNGKPEEKKDDPPKDGNKDDLPKEEKKDDLPKEEKKDDPPKDPKKDDPPKEAQNKLNQPVVADENVDQG
PGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAP
QGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPGAPQGPG
APQGPGAPQEPPQQPPQQPPQQPPQQPPQQPPQQPPQQPRPQPDGNNNNNNNNGNNNEDSYVPSAEQILE
FVKQISSQLTEEWSQCSVTCGSGVRVRKRKNVNKQPENLTLEDIDTEICKMDKCSSIFNIVSNSLGFVIL
LVLVFFN

Epitope Information

IEDB Linear Epitope