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msp-8

General Information
Protegen ID 637
Sequence Strain (Species/Organism) Plasmodium yoelii
VO ID VO_0011221
Taxonomy ID 5861
Other Database IDs CDD:315598
Molecule Role Protective antigen
Molecule Role Annotation Immunization with Plasmodium yoelii merozoite surface protein (PyMSP)-8 protects mice from lethal malaria but does not prevent infection (Petritus and Burns, 2008).
References
Petritus and Burns, 2008: Petritus PM, Burns JM Jr. Suppression of lethal Plasmodium yoelii malaria following protective immunization requires antibody-, IL-4-, and IFN-gamma-dependent responses induced by vaccination and/or challenge infection. Journal of immunology (Baltimore, Md. : 1950). 2008; 180(1); 444-453. [PubMed: 18097046].
Gene Information
Gene Name msp-8
NCBI Gene ID 3792405
Protein Information
Protein Name merozoite surface protein 8
NCBI Protein GI 58197887
Protein pI 4.67
Protein Weight 45677.49
Protein Length 476
Protein Note EGF domain; pfam12947
Protein Sequence 
>AAW65717.1 merozoite surface protein 8 [Plasmodium yoelii]
MKKSSQIIIFLLLSLFCKFSIGNCNENGNGNINKANNNSIIRKERKRKSKSDFSKGEPENKEHEIINLYD
DVQELLGPDEMNMLDKYSILGIDDCSNENENNKIISEYDLKAMKSVLLYKNRISRASINNLDDVKTVFKR
CFNKDDPELSKSYEQIQNQVANEGTTIIDYLSNYISNIYIKINDEFVKNEEFQLSKYIPELEIINYVLYN
GPKEIGNKIKNELIEINNLIISESLTSIYSSVVSGLNINCKIKDDLITILNLANGKYFKVNFSSQATMII
PEQYSHESEHMKKISEYFIEKNRVCKNENCPINSNCYVIDSVETCRCIPGFSKNEESENLECLINESTSC
ENNNGGCDVNANCILLEDKIMCECNNKFNGDGIYCSSAIYYGMNVFIFFLISIVCIYIM
Epitope Information
IEDB Linear Epitope