VIOLIN: Vaccine Investigation and Online Information Network

VP6

General Information

Protegen ID

638

Sequence Strain (Species/Organism)

Murine rotavirus

VO ID

VO_0011222

Taxonomy ID

28327

Other Database IDs

CDD:279341

Molecule Role

Protective antigen

Molecule Role Annotation

Intranasal or oral delivery of the chimeric rotavirus VP6 protein MBP::VP6 to mice elicited >90% reductions in fecal rotavirus shedding after murine rotavirus challenge (McNeal et al., 2007).

Related Vaccines(s)

HSVT[VP7/6/2] , Rotavirus VP6 Protein Vaccine

References

McNeal et al., 2007: McNeal MM, Basu M, Bean JA, Clements JD, Lycke NY, Ramne A, LÃ¶wenadler B, Choi AH, Ward RL. Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge. Vaccine. 2007; 25(33); 6224-6231. [PubMed: 17629371].

Gene Information

Gene Name

VP6

Protein Information

Protein Name

VP6

NCBI Protein GI

268080815

Protein pI

6.05

Protein Weight

42740.75

Protein Length

439

Protein Note

grown in MA104 tissue culture

Protein Sequence

>ACY95265.1 VP6 [Murine rotavirus]
MDVLYSISRTLKDARDKIVEGTLYSNVSDLIQQFNQMLVTMNGNEFQTGGIGNLPLRNWNFDFGLLGTTL
LNLDANYVESARTTIDYFVDFIDNVCMDEMVRESQRNGIAPQSDALRKLSGVKFRRINFNNSSEYIENWN
LQNRRQRTGFTFHKPNIFPYSASFTLNRSQPQHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEH
IVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVILRPNNVEVEFLLNGQVINTYQARFGTI
VARNFDTIRLSFQLMRPPNMTPAVTALFPNAQPFEHHATVGLTLRIDSAICESVLADASETMLANVTSVR
QEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK

Epitope Information

IEDB Linear Epitope