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Pfen

General Information
Protegen ID 639
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
VO ID VO_0011223
Taxonomy ID 36329
Molecule Role Protective antigen
Molecule Role Annotation Mice immunized with r-Pfen (recombinant P. falciparum enolase protein) showed protection against a challenge with the 17XL lethal strain of the mouse malarial parasite Plasmodium yoelii (Pal-Bhowmick et al., 2007).
Related Vaccines(s) P. falciparum Pfen Protein Subunit Vaccine
References
Pal-Bhowmick et al., 2007: Pal-Bhowmick I, Mehta M, Coppens I, Sharma S, Jarori GK. Protective properties and surface localization of Plasmodium falciparum enolase. Infection and immunity. 2007; 75(11); 5500-5508. [PubMed: 17785475].
Gene Information
Gene Name Pfen
NCBI Gene ID 810313
Genbank Accession LN999944
Chromosome No 10
Locus Tag PF3D7_1015900
Gene Starting Position 637137
Gene Ending Position 639010
DNA Sequence 
>NC_037281.1:637137-639010 Plasmodium falciparum 3D7 chromosome 10, complete sequence
AATGGCTCATGTAATAACTCGTATTAATGCCCGTGAAATTTTAGGTATAGATATTTTAATGTTATATATT
TTTTCACTTTGTATATAAATACCTTATTATATGTTTTTAAATAAATGTATATTCAAAGAGCTATATTCAT
TTTTAACTTTTTTTATTTTATATTATAAGAATGAATATGATAGATAAATAAAGATATATATATTATATAT
ATATATATATATATATATTTATTTATTTATTTATTTATACATTAATGTATTAATATGTTTATTTTATGAA
TCCACGTGATATTTCTTTATGAATATGTATTCTATAGTTAACATATAATAATACATACGTATATAATAAG
AATAACATAAGAATAAAATTTTTTTTTATTTTTTTTTTTGTAATACAATAATTTTTTTGTGTATCATTTT
ATTTTATTTTATTTTTAATATCTGAACATATATAATTAAATGTGAAAATTATTTACAATATATATATATA
TATATATATATATATATATATGTTACATTATTACTAATATCTGTATTTTATTTATTTTCTGTTGTTATAT
ATTTTTTTTATATATAGATTCTAGAGGAAACCCAACTGTAGAAGTTGACTTAGAGACCAACTTAGGTATT
TTCAGAGCTGCCGTACCATCTGGTGCCTCCACTGGTATTTATGAAGCCTTAGAATTAAGAGATAATGACA
AGAGCAGGTACTTAGGAAAGGGTGTTCAAAAAGCTATCAAGAACATTAATGAAATTATTGCTCCAAAATT
GATTGGAATGAATTGTACTGAACAAAAGAAAATTGACAATTTAATGGTTGAAGAATTAGATGGAAGTAAA
AATGAATGGGGATGGTCAAAAAGTAAATTAGGAGCTAATGCTATTTTAGCTATATCCATGGCTGTATGTA
GAGCTGGTGCAGCTGCTAATAAAGTATCTTTATACAAATATTTGGCACAATTAGCTGGAAAGAAAAGTGA
CCAAATGGTATTACCAGTACCTTGTTTAAACGTTATCAATGGAGGATCCCATGCAGGAAACAAATTATCT
TTCCAAGAATTTATGATAGTGCCAGTTGGTGCTCCATCATTTAAAGAAGCCTTAAGATATGGTGCTGAAG
TATATCATACCTTAAAATCAGAAATTAAAAAGAAATATGGTATTGATGCAACCAATGTAGGTGATGAAGG
TGGATTTGCTCCAAATATATTAAACGCTAATGAAGCTCTTGATTTATTAGTAACTGCCATTAAATCAGCT
GGTTATGAAGGAAAGGTTAAAATTGCTATGGATGTTGCAGCTTCTGAATTTTACAACAGTGAAAACAAAA
CATACGATTTAGATTTCAAAACTCCAAATAATGACAAATCATTAGTTAAGACTGGAGCTCAATTAGTTGA
CTTATACATTGATTTAGTAAAGAAATATCCAATTGTTTCTATTGAAGATCCATTTGATCAAGATGATTGG
GAAAATTATGCTAAATTAACAGCAGCTATTGGAAAGGATGTTCAAATTGTTGGTGATGATTTATTAGTTA
CAAACCCAACCAGAATTACTAAAGCTCTTGAAAAAAATGCTTGCAATGCTTTACTTCTTAAAGTTAACCA
AATCGGTTCTATTACTGAAGCTATTGAAGCTTGCTTATTATCTCAAAAAAATAACTGGGGTGTTATGGTT
TCTCACAGATCTGGTGAAACCGAAGATGTTTTTATTGCTGATTTAGTTGTTGCTTTAAGAACCGGACAAA
TCAAAACAGGAGCACCATGCAGAAGTGAAAGAAACGCCAAATATAACCAATTATTAAGAATTGAAGAATC
TTTAGGAAACAATGCTGTTTTTGCTGGAGAAAAATTTAGATTACAATTAAATTA
Protein Information
NCBI Protein GI 124802328
Protein Accession XP_001347440
Protein pI 6.54
Protein Weight 45501.97
Protein Length 446
Protein Sequence 
>XP_001347440.1 enolase [Plasmodium falciparum 3D7]
MAHVITRINAREILDSRGNPTVEVDLETNLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQKAIKN
INEIIAPKLIGMNCTEQKKIDNLMVEELDGSKNEWGWSKSKLGANAILAISMAVCRAGAAANKVSLYKYL
AQLAGKKSDQMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGI
DATNVGDEGGFAPNILNANEALDLLVTAIKSAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSL
VKTGAQLVDLYIDLVKKYPIVSIEDPFDQDDWENYAKLTAAIGKDVQIVGDDLLVTNPTRITKALEKNAC
NALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKY
NQLLRIEESLGNNAVFAGEKFRLQLN
Epitope Information
IEDB Linear Epitope