VIOLIN: Vaccine Investigation and Online Information Network

AMA-1 from P. berghei

General Information

Protegen ID

640

Sequence Strain (Species/Organism)

Plasmodium berghei

VO ID

VO_0011224

Taxonomy ID

5821

Other Database IDs

CDD:280571

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with recombinant PbAMA-1 were partially protected from the challenge of P. berghei (Li et al., 2007).

References

Li et al., 2007: Li SL, Zhang DM, Cao Y, Pan WQ. [Expression and immunogenicity evaluation of ectodomain and subdomains of Plasmodium berghei apical membrane antigen 1]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. 2007; 25(1); 1-5. [PubMed: 17639690].

Gene Information

Gene Name

AMA-1 from P. berghei

NCBI Gene ID

55149604

Protein Information

Protein Name

apical membrane antigen-1

NCBI Protein GI

1438889

Protein pI

6.68

Protein Weight

61320.86

Protein Length

624

Protein Note

Apical membrane antigen 1; pfam02430

Protein Sequence

>AAC47192.1 apical membrane antigen-1 [Plasmodium berghei]
MKEIYYILILCSIYLINLSNCSEGPNNVISENGHINYDMIQKENTERSTKLINPWEKYTEKYDIERMHGS
GIRVDLGEDARVENRDYRIPSGKCPVIGKGITIQNSEVSFLTPVATGDQSVRSGGLALPKTDVHLSPITI
DNLKTMYKEHTEIVKLNNMSLCAKHTSFYVPGNNANSAYRHPAVYDKSNSTCYMLYVAAQENMGPRYCSN
NANNDNQPFCFTPEKIEKYKNLSYLTKNLRDDWETSCPNKSIKNAKFGIWVDGYCKDYQKHTVHDSDSLL
KCNQIIFNESASDQPKQYEKHLEDTTKFRQGVAERNGKLIGEALLPIGSYKSDQIKSHGRGYNWGNYDSQ
NKKCYIFETKPTCLINDRNFIATTALSSTEEFEEQFPCDIYKNKINEEIKVLNKNISNGNNSIEFPRIFI
STDKNSLNCPCEPTQLTESSCNFYVCNCVEKRQYIAENNDVEIKEELEVHMKAHQTREVIVIIIFICVGI
ILVILLVGYFFKSNKKGENYDRMGQADIYGKANSRKDGMLDPEVSFWGEDKRASHTTPVLMEKPYY

Epitope Information

IEDB Linear Epitope