VIOLIN: Vaccine Investigation and Online Information Network

VP7

General Information

Protegen ID

642

Sequence Strain (Species/Organism)

Bovine rotavirus

VO ID

VO_0011226

Taxonomy ID

10927

Other Database IDs

CDD:278842

Molecule Role

Protective antigen

Molecule Role Annotation

Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system. Neonates of animals immunized with virus-like particles composed of VP7 assembled on VP6 spherical particles were protected against challenge with the homotypic virus and significantly protected from a heterotypic challenge. Unassembled VP7 protein provided partial protection against challenge (Redmond et al., 1993).

Related Vaccines(s)

Rotavirus VP4/VP7 Protein Vaccine

References

Redmond et al., 1993: Redmond MJ, Ijaz MK, Parker MD, Sabara MI, Dent D, Gibbons E, Babiuk LA. Assembly of recombinant rotavirus proteins into virus-like particles and assessment of vaccine potential. Vaccine. 1993; 11(2); 273-281. [PubMed: 8382422].

Gene Information

Gene Name

VP7

Protein Information

Protein Name

VP7

NCBI Protein GI

195661008

Protein pI

4.62

Protein Weight

35315.62

Protein Length

367

Protein Note

Glycoprotein VP7; pfam00434

Protein Sequence

>ACG50682.1 VP7 [Bovine rotavirus]
MYGIEYTTILIFLTSITLLNYILKSITRMMDYIIYRFLLIAVILATMINAQNYGVNLPITGSMDTAYANS
TQSEPFLTSTLCLYYPVEASNEMADTEWKDTISQLFLTKGWPTGSVYFKEYTDIAAFSVEPQLYCDYNLV
LMKYDSTQKLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTVKVCPLNTQTLGIGCLIT
NPDTFETVATTEKLVITDVVDGVNHKLNVTTATCTIRNCKKLGPRENVAVIQVGGANILDITADPTTTPQ
TERMMRINWKKWWQVFYTVVDYVNQIIQTMSKRSRSLNSSAFYYRV

Epitope Information

IEDB Linear Epitope