VIOLIN: Vaccine Investigation and Online Information Network

VP4

General Information

Protegen ID

643

Sequence Strain (Species/Organism)

Bovine rotavirus

VO ID

VO_0011227

Taxonomy ID

10927

Other Database IDs

CDD:189541

Molecule Role

Protective antigen

Molecule Role Annotation

Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system. Challenge of neonates born to animals immunized with VP4 protein on assembled particles or in cell lysates showed protection against challenge with both homologous (bovine C486) and heterologous (SA-11) strains of rotavirus (Redmond et al., 1993).

Related Vaccines(s)

Rotavirus VP4/VP7 Protein Vaccine

References

Redmond et al., 1993: Redmond MJ, Ijaz MK, Parker MD, Sabara MI, Dent D, Gibbons E, Babiuk LA. Assembly of recombinant rotavirus proteins into virus-like particles and assessment of vaccine potential. Vaccine. 1993; 11(2); 273-281. [PubMed: 8382422].

Gene Information

Gene Name

VP4

Protein Information

Protein Name

VP4

NCBI Protein GI

172054621

Protein pI

5.74

Protein Weight

31092.2

Protein Length

341

Protein Note

Outer Capsid protein VP4 (Hemagglutinin); pfam00426

Protein Sequence

>ACB71152.1 VP4, partial [Bovine rotavirus]
ASLIYRQLLTNSYTVNLSDEIQEIGSAKSQDVTINPGPFAQTGYAPVNWGAGETNDSTTVEPLLDGPYQP
TTFNPPTSYWVLLAPTVEGVIIQGTNNTDRWLATILIEPNVQTTNRIYNLFGQQVTLSVENTSQTQWKFI
DVSTTTPTGSYTQHGPLFSTPKLYAVMKFSGRIYTYSGNTPNATTGYYSTTNYDTLNMTSFCDFYIIPRN
QEEKCTEYINHGLPPIQNTRNVVPVSLSAREIVHTRAQVNEDIVVSKTSLWKEMQYNRDITIRFKFDRTI
IKAGGLGYKWS

Epitope Information

IEDB Linear Epitope