VIOLIN: Vaccine Investigation and Online Information Network

HEP17

General Information

Protegen ID

644

Sequence Strain (Species/Organism)

Plasmodium yoelii

VO ID

VO_0011228

Taxonomy ID

5861

Other Database IDs

CDD:284100

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization of mice with subunit vaccines based on the Plasmodium yoelii 17kDa hepatocyte erythrocyte protein (PyHEP17), orthologue of Plasmodium falciparum exported protein 1 (PfExp1), induces antigen-specific immune responses and protects against sporozoite challenge (Dobaño and Doolan, 2007).

Related Vaccines(s)

P. yoelii DNA vaccine encoding PyHEP17 Protein

References

DobaÃ±o and Doolan, 2007: DobaÃ±o C, Doolan DL. Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa. Molecular immunology. 2007; 44(11); 3037-3048. [PubMed: 17303242].

Gene Information

Gene Name

HEP17

NCBI Gene ID

3790041

Protein Information

Protein Name

hepatocyte erythrocyte protein 17 kDa

NCBI Protein GI

1399353

Protein pI

10.09

Protein Weight

17587.89

Protein Length

243

Protein Note

Circumsporozoite-related antigen (CRA); pfam06589

Protein Sequence

>AAC47199.1 hepatocyte erythrocyte protein 17 kDa [Plasmodium yoelii]
MKINIASIIFIIFSLCLVNDAYGKNKYGKNGKYGSQNVIKKHGEPVINVQDLISDMVRKEEEIVKLTKNK
KSLRKINVALATALSVVSAILLGGAGLVMYNTEKGRRPFQIGKSKKGGSAMARDSSFPMNEESPLGFSPE
EMEAVASKFRESMLKDGVPAPSNTPNVQN

Epitope Information

IEDB Linear Epitope