MSP1 from P.vivax
General Information
Protegen ID
646
Sequence Strain (Species/Organism)
Plasmodium vivax
VO ID
VO_0011230
Taxonomy ID
5855
Other Database IDs
CDD:299863
Molecule Role
Protective antigen
Molecule Role Annotation
Immunization of BALB/c mice and Aotus monkeys with PvMSP-1 induced IgG antibodies (titer > 10(6)) that cross-reacted with P. vivax parasites. Immunized monkeys displayed partial protection against a challenge with P. vivax blood stages (Valderrama-Aguirre et al. , 2005 ).
References
Valderrama-Aguirre et al. , 2005: Valderrama-Aguirre A, Quintero G, Gómez A, Castellanos A, Pérez Y, Méndez F, Arévalo-Herrera M, Herrera S. Antigenicity, immunogenicity, and protective efficacy of Plasmodium vivax MSP1 PV200l: a potential malaria vaccine subunit. The American journal of tropical medicine and hygiene . 2005; 73(5 Suppl); 16-24. [PubMed: 16291762 ].
Gene Information
Gene Name
MSP1 from P.vivax
NCBI Nucleotide GI
AF435639.1
Protein Information
Protein Name
merozoite surface protein 1
NCBI Protein GI
26985160
3D structure: PDB ID
2NPR
Protein pI
7.06
Protein Weight
187587.32
Protein Length
1844
Protein Note
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
Protein Sequence
>AAN86248.1 merozoite surface protein 1 [Plasmodium vivax]
MKALLFLFSFIFFVTKCQCETESYKQLVAKLDKLEALVVDGYELFHKKKLGESDIQVETNASANNNNNNQ
VSVLTSKIRNFVGKFLELQIPGHTDLLHLIRELAFEPNGIKYLVESYEEFNQLMHVINFHYDLLRAKLHD
MCAHDYCKIPEHLKISDKELDMLKKVVLGYRKPLDNIKDDIGKLETFITKNKITIKNISDLIIAENKKRS
GHPTTTTNGAGTQPANGSIAAASSETTQISGSSNSGSTGHGSSNSGSTGHGSSNSGSSGTGSSNSGSSGT
GSTGNGQSPPATADASSTNANYEAKKIIYQAVYNTIFYTNQLQEAQKLIAVLEKRVKVLKEHKDIKVLLE
KIATEKGKFPNNNLNVENPTDEQKTAKSNIADLEKKIEAIAKTVNFDLDGLFTDAEELEYYLREKAKMAG
TLIIPESTKSAGTPGKTVPTLKETYPHGISYALAENSIYELIEKIGSDETFGDLQNPDDGKQPKKGILIN
ETKRKELLEKIMNKIKIEEDKLPDLKKEYEEKYTVYEQKVKEFQPEFNYFYEARLDNTLVGEKFGEFKKK
REEYMKEKKKLESCSYEQNTNLINKLKKQLTYLEDYVLRKDIADDEIKHFSFMEWKLKSEIYDLAQEIRK
NENKLTIENKFDFSGVVELQVQKVLIIKKIEALKNVQNLLKNAKVKDDLYVPKVYKTGEKPEPYYLMVLK
REIDKLKDFIPKIESMIATEKNKPTVAAADIVAKGQSLRGASETGTTGNTVNAQTAVVQQPQHQVVNAVT
VQPGTTGHQAQGGEAETQTNSVQAAQVQQTPAGAGGQVASTQTTSQAPAPTQASPEPAPAAPPSTPAAAV
APAPAMSKLEYLEKLLDFLKSAYACHKHIFVTNSTMDKKLLKEYELNADEKTKINQNKCDELDLLFNVQN
NLPAMYSIYDSMSNELQNLYIELYQKEMVYNIYKNKDTDKKIKAFLETSNNKAAAPAQSAAKPSGQAGTT
PVTTTAPVTTTTVTPSPQTSVVTSTPPTPQAEENQRVGGNSEEKPEADTAQVEKFYEKHLSQIDKYNDYF
KKFLESKKEEIIKMDDTKWNALGKEIEELKKKLQVSLDHYGKYKLKLERFLKKKNKISNSKDQIKKLTSL
KNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEE
SMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLLHVLTELKEIINDKKYSGKDHAKNIAEV
KKALQAYQELIPKVTSQESTSVAVTVPGAVVPGVPTAAAAGSGASGAVPPATGGVVPGVVESAEAQTQTQ
AQDYAEDYDKVIALPLFGNNDDDGEEDQVTTGEAESEAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLE
NHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGAS
IDKDLATANDGVAYYNKMGELYKTHLDGVKTEIKKVEDDIKTHDEKLQKLGSEVSQNSEKTQLNAKKAEL
EKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAEITVKKLQDYNKMDEKLEEYKKSEKKNE
VKSSGLLEKLMKSKLIKENESKEILSQLLNVQTQLLTMSSEHTCIDTNVPDNAACYRYLDGTEEWRCLLT
FKEEGGKCVPASNVTCKDNNGGCAPEAECKMTDSNKIVCKCTKEGSEPLFEGVFCSSSSFLSLSFLLLML
LFLLCMEL
Epitope Information
IEDB Linear Epitope
-- Assay Type --
T Cell Epitope
B Cell Epitope
IEDB ID
Epitope
Starting position
Ending position
35783 LEYYLREK
408
416
481923 LNPFKYSSSGEYIIKDPY
1432
1450
475489 AFNTNITDMLDSRLKKRN
1405
1423
MKALLFLFSFIFFVTKCQCETESYKQLVAKLDKLEALVVDGYELFHKKKLGESDIQVETNASANNNNNNQVSVLTSKIRNFVGKFLELQIPGHTDLLHLIRELAFEPNGIKYLVESYEEFNQLMHVINFHYDLLRAKLHDMCAHDYCKIPEHLKISDKELDMLKKVVLGYRKPLDNIKDDIGKLETFITKNKITIKNISDLIIAENKKRSGHPTTTTNGAGTQPANGSIAAASSETTQISGSSNSGSTGHGSSNSGSTGHGSSNSGSSGTGSSNSGSSGTGSTGNGQSPPATADASSTNANYEAKKIIYQAVYNTIFYTNQLQEAQKLIAVLEKRVKVLKEHKDIKVLLEKIATEKGKFPNNNLNVENPTDEQKTAKSNIADLEKKIEAIAKTVNFDLDGLFTDAEELEYYLREKAKMAGTLIIPESTKSAGTPGKTVPTLKETYPHGISYALAENSIYELIEKIGSDETFGDLQNPDDGKQPKKGILINETKRKELLEKIMNKIKIEEDKLPDLKKEYEEKYTVYEQKVKEFQPEFNYFYEARLDNTLVGEKFGEFKKKREEYMKEKKKLESCSYEQNTNLINKLKKQLTYLEDYVLRKDIADDEIKHFSFMEWKLKSEIYDLAQEIRKNENKLTIENKFDFSGVVELQVQKVLIIKKIEALKNVQNLLKNAKVKDDLYVPKVYKTGEKPEPYYLMVLKREIDKLKDFIPKIESMIATEKNKPTVAAADIVAKGQSLRGASETGTTGNTVNAQTAVVQQPQHQVVNAVTVQPGTTGHQAQGGEAETQTNSVQAAQVQQTPAGAGGQVASTQTTSQAPAPTQASPEPAPAAPPSTPAAAVAPAPAMSKLEYLEKLLDFLKSAYACHKHIFVTNSTMDKKLLKEYELNADEKTKINQNKCDELDLLFNVQNNLPAMYSIYDSMSNELQNLYIELYQKEMVYNIYKNKDTDKKIKAFLETSNNKAAAPAQSAAKPSGQAGTTPVTTTAPVTTTTVTPSPQTSVVTSTPPTPQAEENQRVGGNSEEKPEADTAQVEKFYEKHLSQIDKYNDYFKKFLESKKEEIIKMDDTKWNALGKEIEELKKKLQVSLDHYGKYKLKLERFLKKKNKISNSKDQIKKLTSLKNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLLHVLTELKEIINDKKYSGKDHAKNIAEVKKALQAYQELIPKVTSQESTSVAVTVPGAVVPGVPTAAAAGSGASGAVPPATGGVVPGVVESAEAQTQTQAQDYAEDYDKVIALPLFGNNDDDGEEDQVTTGEAESEAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLENHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGASIDKDLATANDGVAYYNKMGELYKTHLDGVKTEIKKVEDDIKTHDEKLQKLGSEVSQNSEKTQLNAKKAELEKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAEITVKKLQDYNKMDEKLEEYKKSEKKNEVKSSGLLEKLMKSKLIKENESKEILSQLLNVQTQLLTMSSEHTCIDTNVPDNAACYRYLDGTEEWRCLLTFKEEGGKCVPASNVTCKDNNGGCAPEAECKMTDSNKIVCKCTKEGSEPLFEGVFCSSSSFLSLSFLLLMLLFLLCMEL
