VIOLIN: Vaccine Investigation and Online Information Network

G

General Information

Protegen ID

647

Sequence Strain (Species/Organism)

Rabies virus

VO ID

VO_0011231

Taxonomy ID

11292

Other Database IDs

CDD:279337

Molecule Role

Protective antigen

Molecule Role Annotation

A DNA vaccine based on lysosome-targeted glycoprotein of the rabies virus was evaluated in BALB/c mice. It imparted partial protection (60%) against challenge with 20 LD(50) of the challenge virus standard (CVS) strain of rabies virus (Kaur et al., 2010).

Related Vaccines(s)

AdC68- rabies virus glycoprotein , Rabies DNA Vaccine encoding Rabies virus Glycoprotein , Rabies virus DNA vaccine pCMV-intA-rabies encoding glycoprotein G , Rabies Virus Vaccine pAlpha-Rab-G

References

Kaur et al., 2010: Kaur M, Saxena A, Rai A, Bhatnagar R. Rabies DNA vaccine encoding lysosome-targeted glycoprotein supplemented with Emulsigen-D confers complete protection in preexposure and postexposure studies in BALB/c mice. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010; 24(1); 173-183. [PubMed: 19741168].

Gene Information

Gene Name

Protein Information

Protein Name

glycoprotein

NCBI Protein GI

56384945

Protein pI

7.66

Protein Weight

55317.81

Protein Length

578

Protein Note

Rhabdovirus spike glycoprotein; pfam00974

Protein Sequence

>AAV85905.1 glycoprotein [Rabies lyssavirus]
MVPQALLFVPFLGFSLCFGKFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGFSYLELKVGHI
SAIKVNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKTAGDPRYEESLQNPYPDYQW
LRTVRTTKESLVIISPSAADLDPYDKSLHSRVFPSGKCSGITVSSVYCSTNHDYTIWMPENPRQGMSCDI
FTNSRGKRASKERKTCGFVDERGLYKSLRGSCKLKLCGVLGLRLMDGTWVAMQTSNETKWCSPDQLVNLH
DFHSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIINKTLMEAEAHYKS
VRTWNEIVPSKGCLRVEGRCHPHVNGVFFNGIILGPDGHVLIPEMQSSLLQQHMELLESSVIPLMHPLAD
PSTVFKEGDEAEDFVEVHFPDVHKKVSEVDLGLPNWGEYVLLSAGTLIALMLIIFLMICRRRVNRPESTQ
RSLRGTEMKVSVTPQSGKFKSSWESYKSGDEARL

Epitope Information

IEDB Linear Epitope