VIOLIN: Vaccine Investigation and Online Information Network

ompB

General Information

Protegen ID

651

Sequence Strain (Species/Organism)

Rickettsia rickettsii

VO ID

VO_0011235

Taxonomy ID

783

Other Database IDs

CDD:289131
CDD:273608
CDD:214872

Molecule Role

Protective antigen

Molecule Role Annotation

R. rickettsii OmpB contain B and T lymphocyte epitopes. Immunizations with each of two fragments from OmpB (rompB1550-2738 and rompB2459-4123) conferred protection against challenge with a lethal dose of R. conorii. Protection appeared to be better achieved among the groups that received both DNA and recombinant protein immunizations, although recombinant protein immunizations alone provided some protection (Díaz-Montero et al., 2001).

Related Vaccines(s)

Rickettsia DNA Vaccine encoding OmpB Protein boosted with Recombinant OmpB

References

DÃaz-Montero et al., 2001: DÃaz-Montero CM, Feng HM, Crocquet-Valdes PA, Walker DH. Identification of protective components of two major outer membrane proteins of spotted fever group Rickettsiae. The American journal of tropical medicine and hygiene. 2001; 65(4); 371-378. [PubMed: 11693887].

Gene Information

Gene Name

ompB

Protein Information

Protein Name

Outer membrane protein B

NCBI Protein GI

6685726

Protein pI

6.04

Protein Weight

160418.03

Protein Length

2141

Protein Note

168 kDa surface-layer protein; Cell surface antigen 5; Surface protein antigen; rOmp B; Sca5; rOmpB

Protein Sequence

>sp|Q53047.1|OMPB_RICRI RecName: Full=Outer membrane protein B; AltName: Full=168 kDa surface-layer protein; AltName: Full=Cell surface antigen 5; Short=Sca5; AltName: Full=Surface protein antigen; AltName: Full=rOmp B; Short=rOmpB; Contains: RecName: Full=120 kDa surface-exposed protein; AltName: Full=120 kDa outer membrane protein OmpB; AltName: Full=Surface protein antigen; AltName: Full=p120; Contains: RecName: Full=32 kDa beta peptide; Flags: Precursor
MAQKPNFLKKLISAGLVTASTATIVASFAGSAMGAAIQQNRTTNGAATTVDGAGFDQTAAPANVGVALNA
VITANANNGINFNTPAGSFNGLLLNTANNLAVTVSEDTTLGFITNVVHNAHSFNLTLNAGKTLTITGQGV
TNAQAAATKNAQNVVVQFNNGAAIDNNDLKGVGRIDFGAPASTLVFNLANPTTQKAPLILGDNAVIANGV
NGTLNVTNGFIQVSNKSFATVKAINIADGQGIIFNTDANNANTLNLQAGGTTINFTGTDGTGRLVLLSKH
AAATNFNITGSLGGNLKGVIEFNTVAVDGQLTANAGAANAVIGTNNGAGRAAGFVVSVDNGKVATIDGQV
YAKDMVIQSANATGQVNFRHIVDVGADGTTAFKTAASKVTITQDSNFGNTDFGNLAAQIKVPNAITLTGN
FTGDASNPGNTAGVITFDANGTLESASADANVAVTNNITAIEASGAGVVQLSGTHAAELRLGNAGSIFKL
ADGTVINGKVNQTALVGGALAAGTITLDGSATITGDIGNAGGAAALQRITLANDAKKTLTLGGANIIGAG
GGTIDLQANGGTIKLTSTQNNIVVDFDLAIATDQTGVVDASSLTNAQTLTINGKIGTIGANNKTLGQFNI
GSSKTVLSNGNVAINELVIGNDGAVQFAHDTYLITRTTNAAGQGKIIFNPVVNNGTTLAAGTNLGSATNP
LAEINFGSKGVNVDTVLNVGEGVNLYATNITTTDANVGSFVFNAGGTNIVSGTVGGQQGNKFNTVALENG
TTVKFLGNATFNGNTTIAANSTLQIGGNYTADCVASADGTGIVEFVNTGPITVTLNKQAAPVNALKQITV
SGPGNVVINEIGNAGNHHGAVTDTIAFENSSLGAVVFLPRGIPFNDAGNTMPLTIKSTVGNKTAKGFDVP
SVVVLGVDSVIADGQVIGDQNNIVGLGLGSDNGIIVNATTLYAGISTLNNNQGTVTLSGGVPNTPGTVYG
LGTGIGASKFKQVTFTTDYNNLGNIIATNATINDGVTVTTGGIAGIGFDGKITLGSVNGNGNVRFADGIL
SNSTSMIGTTKANNGTVTYLGNAFVGNIGDSDTPVASVRFTGSDSGAGLQGNIYSQVIDFGTYNLGIVNS
NIILGGGTTAINGKIDLVTNTLTFASGTSTWGNNTSIETTLTLANGNIGHIVILEGAQVNTTTTGTTTIK
VQDNANANFSGTQTYTLIQGGARFNGTLGSPNFAVTGSNRFVNYSLIRAANQDYVITRTNNAENVVTNDI
ANSPFGGAPGVDQNVTTFVNATNTAAYNNLLLAKNSANSANFVGAIVTDTSAAITNVQLDLAKDIQAQLG
NRLGALRYLGTPETAEMAGPEAGAISAAVAAGDEAIDNVAYGIWAKPFYTDAHQSKKGGLAGYKAKTTGV
VIGLDTLANDNLMIGAAIGITKTDIKHQDYKKGDKTDVNGFSFSLYGAQQLVKNFFAQGSAIFSLNQVKN
KSQRYFFDANGNMSKQIAAGHYDNMTFGGNLTVGYDYNAMQGVLVTPMAGLSYLKSSDENYKETGTTVAN
KQVNSKFSDRTDLIVGAKVAGSTMNITDLAVYPEVHAFVVHKVTGRLSKTQSVLDGQVTPCINQPDRTTK
TSYNLGLSASIRSDAKMEYGIGYDAQISSKYTAHQGTLKVRVNF

Epitope Information

IEDB Linear Epitope