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MSP4/5

General Information
Protegen ID 652
Sequence Strain (Species/Organism) Plasmodium yoelii
VO ID VO_0011236
Taxonomy ID 73239
Other Database IDs CDD:289699
Molecule Role Protective antigen
Molecule Role Annotation Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection (Wang et al., 2004).
Related Vaccines(s) P. yoelii MSP1 and MSP4/5 Proteins Subunit Vaccine
References
Wang et al., 2004: Wang L, Goschnick MW, Coppel RL. Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge. Infection and immunity. 2004; 72(10); 6172-6175. [PubMed: 15385527].
Gene Information
Gene Name MSP4/5
NCBI Gene ID 3800676
NCBI Nucleotide GI AY563017.1
Protein Information
Protein Name merozoite surface protein 4/5
NCBI Protein GI 49798469
Protein pI 4.1
Protein Weight 18420.75
Protein Length 253
Protein Note EGF domain; pfam12947
Protein Sequence
>AAT68597.1 merozoite surface protein 4/5, partial [Plasmodium yoelii yoelii]
VHEISLINTKKYQRNIFCAKRILGDPPSANPSTSLNQNEDNHNSNPDANKGNTNKSDKLNGDNIPNSQSK
SENTNLSESPKTGTASNPPQPEPSVQPGNTNGDSQNSIHSDDEEEDDEDEDDDEEDCSVNNGGCGENLLC
EKMESGIIKCSCPSGYKLNGTSCIELLSAHS

Epitope Information
IEDB Linear Epitope