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US6

General Information
Protegen ID 656
Sequence Strain (Species/Organism) Suid alphaherpesvirus 1
VO ID VO_0011240
Taxonomy ID 10345
Molecule Role Protective antigen
Molecule Role Annotation The pseudorabies virus (PrV) DNA vaccine carrying the glycoprotein D (gD) gene delivered by E. coli was able to induce protective immune responses in mice against a lethal PrV challenge (Shiau et al., 2001). Immunization of mice with affinity-purified gD of Aujeszky's disease virus (ADV, Suid herpesvirus 1) induced a strong humoral immune response and protected mice against lethal ADV challenge (Vrublevskaia et al., 2007).
References
Shiau et al., 2001: Shiau AL, Chu CY, Su WC, Wu CL. Vaccination with the glycoprotein D gene of pseudorabies virus delivered by nonpathogenic Escherichia coli elicits protective immune responses. Vaccine. 2001; 19(23-24); 3277-3284. [PubMed: 11312026].
Vrublevskaia et al., 2007: Vrublevskaia VV, Musienko VS, Skarga IuIu, Morenkov OS. [Immunological characteristics of Aujeszky's disease virus glycoprotein]. Voprosy virusologii. 2007; 52(3); 33-37. [PubMed: 17601050].
Gene Information
Gene Name US6
NCBI Gene ID 2952521
Genbank Accession BK001744
Locus Tag SuHV1_gp68
Gene Starting Position 121023
Gene Ending Position 123397
DNA Sequence 
>NC_006151.1:121023-123397 Suid herpesvirus 1, complete genome
CCATAAAATTGGGTGGGGGCCCCAGGTTCCCATACACTCACCTGCCAGCGCCATGCTGCTCGCAGCGCTA
TTGGCGGCGCTGGTCGCCCGGACGACGCTCGGCGCGGACGTGGACGCCGTGCCCGCGCCGACCTTCCCCC
CGCCCGCGTACCCGTACACCGAGTCGTGGCAGCTGACGCTGACGACGGTCCCCTCGCCCTTCGTCGGCCC
CGCGGACGTCTACCACACGCGCCCGCTGGAGGACCCGTGCGGGGTGGTGGCGCTGATCTCCGACCCGCAG
GTGGACCGGCTGCTGAACGAGGCGGTGGCCCACCGGCGGCCCACGTACCGCGCCCACGTGGCCTGGTACC
GCATCGCGGACGGGTGCGCGCACCTGCTGTACTTTATCGAGTACGCCGACTGCGACCCCAGGCAGATCTT
TGGGCGCTGCCGGCGCCGCACCACGCCGATGTGGTGGACCCCGTCCGCGGACTACATGTTCCCCACGGAG
GACGAGCTGGGGCTGCTCATGGTGGCTCCGGGGCGGTTCAACGAGGGCCAGTACCGGCGCCTGGTGTCCG
TCGACGGCGTGAACATCCTCACCGACTTCATGGTGGCGCTCCCCGAGGGGCAAGAGTGCCCGTTCGCCCG
CGTGGACCAGCACCGCACGTACAAGTTCGGCGCGTGCTGGAACGACGAGAGCTTCAGGCGGGGCGTGGAC
GTGATGCGATTCCTGACGCCGTTCTACCAGCAGCCCCCGCACCGGGAGGTGGTGAACTACTGGTACCGCA
AGAACGGCCGGACGCTCCCGCGGGCCTACGCCGCCGCCACGCCGTACGCCATCGACCCCGCGCGGCCCTC
GGCGGGCTCGCCGAGGCCCAGGCCCCGGCCCCGGCCCCGGCCGAAGCCCGAGCCCGCCCCGGTGACGCCC
GCGCCCCCCGGCCGCCTGCCCGAGCCGGCGACGCGGGACCACGCCGCCGGGGGCCACCCCACGCCGCGAC
CCCCGAGGCCCGAGACGCCGCACCGCCCCTTCGCCCCGCCGGCCGTCGTGCCCAGCGGGTGGCCGCAGCC
CGCGGAGCCGTTCCAGCCGCGGACCCCCGCCGCGCCGGGCGTCTCGCGCCACCGCTCGGTGATCGTCGGC
ACGGGCACCGCGATGGGCGCGCTCCTGGTGGGCGTGTGCGTCTACATCTTCTTCCGCCTGAGGGGGGCGA
AGGGGTATCGCCTCCTGGGCGGTCCCGCGGACACCGACGAGCTAAAAGCGCAGCCCGGTCCGTAGCCTCC
GCAGTACCGGCGTCGATGATGATGGTGGCGCGCGACGTGACCCGGCTCCCCGCGGGGCTCCTCCTCGCCG
CCCTGACCCTGGCCGCCCTGACCCCGCGCGTCGGGGGCGTCCTCTTCAGGGGCGCCGGCGTCAGCGTGCA
CGTCGCCGGCAGCGCCGTCCTCGTGCCCGGCGACGCGCCCAACCTGACGATCGACGGGACGCTGCTGTTT
CTGGAGGGGCCCTCGCCGAGCAACTACAGCGGGCGCGTGGAGCTGCTGCGCCTCGACCCCAAGCGCGCCT
GCTACACGCGCGAGTACGCCGCCGAGTACGACCTCTGCCCCCGCGTGCACCACGAGGCCTTCCGCGGCTG
TCTGCGCAAGCGCGAGCCGCTCGCCCGGCGCGCGTCCGCCGCGGTGGAGGCGCGCCGGCTGCTGTTCGTC
TCGCGCCCGGCCCCGCCGGACGCGGGGTCGTACGTGCTGCGGGTCCGCGTGAACGGGACCACGGACCTCT
TTGTGCTGACGGCCCTGGTGCCGCCCAGGGGGCGCCCCCACCACCCCACGCCGTCGTCCGCGGACGAGTG
CCGGCCCGTCGTCGGATCGTGGCACGACAGCCTGCGCGTCGTGGACCCCGCCGAGGACGCCGTGTTCACC
ACGCCGCCCCCGATCGAGCCAGAGCCGCCGACGACCCCCGCGCCCCCCCGGGGGACCGGCGCCACCCCCG
AGCCCCGCTCCGACGAAGAGGAGGAGGACGAGGAGGGGGCGACGACGGCGATGACCCCGGTGCCCGGGAC
CCTGGACGCGAACGGCACGATGGTGCTGAACGCCAGCGTCGTGTCGCGCGTCCTGCTCGCCGCCGCCAAC
GCCACGGCGGGCGCCCGGGGCCCCGGGAAGATAGCCATGGTGCTGGGGCCCACGATCGTCGTCCTCCTGA
TCTTCTTGGGCGGGGTCGCCTGCGCGGCCCGGCGCTGCGCGCGGAATCGCATCTACCGGCCGCGACCCGG
GCGCGGCCCGGCGGTCCACGCGCCGCCCCCGCGGCGCCCGCCCCCCAGCCCCGTCGCCGGGGCGCCCGTC
CCCCAGCCCAAGATGACGTTGGCCGAGCTTCGCCAGAAGCTGGCCACCATCGCAGAGGAACAATA
Protein Information
Protein Name envelope glycoprotein D
NCBI Protein GI 51557553
Protein Accession YP_068387
Protein pI 9.38
Protein Weight 41362.03
Protein Length 400
Protein Note envelope glycoprotein D; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment
Protein Sequence 
>YP_068387.1 envelope glycoprotein D [Suid alphaherpesvirus 1]
MLLAALLAALVARTTLGADVDAVPAPTFPPPAYPYTESWQLTLTTVPSPFVGPADVYHTRPLEDPCGVVA
LISDPQVDRLLNEAVAHRRPTYRAHVAWYRIADGCAHLLYFIEYADCDPRQIFGRCRRRTTPMWWTPSAD
YMFPTEDELGLLMVAPGRFNEGQYRRLVSVDGVNILTDFMVALPEGQECPFARVDQHRTYKFGACWNDES
FRRGVDVMRFLTPFYQQPPHREVVNYWYRKNGRTLPRAYAAATPYAIDPARPSAGSPRPRPRPRPRPKPE
PAPVTPAPPGRLPEPATRDHAAGGHPTPRPPRPETPHRPFAPPAVVPSGWPQPAEPFQPRTPAAPGVSRH
RSVIVGTGTAMGALLVGVCVYIFFRLRGAKGYRLLGGPADTDELKAQPGP
Epitope Information
IEDB Linear Epitope