VIOLIN: Vaccine Investigation and Online Information Network

VP2

General Information

Protegen ID

673

Sequence Strain (Species/Organism)

Rotavirus sp.

VO ID

VO_0011254

Taxonomy ID

10970

Other Database IDs

CDD:282884

Molecule Role

Protective antigen

Molecule Role Annotation

Both inbred BALB/c and outbred CD-1 mice were immunized with rotavirus VP2/6-rVLPs (2/6-VLPs) combined with CT-E29H, orally or intranasally (i.n.), and the comparative efficacy of different formulations was then determined. Two immunizations with 2-6VLPs and CT-E29H were sufficient to protect BALB/c mice, regardless of the route of administration (Siadat-Pajouh and Cai, 2001).

Related Vaccines(s)

HSVT[VP7/6/2] , Rotavirus VP2/VP 6 Protein Vaccine

References

Siadat-Pajouh and Cai, 2001: Siadat-Pajouh M, Cai L. Protective efficacy of rotavirus 2/6-virus-like particles combined with CT-E29H, a detoxified cholera toxin adjuvant. Viral immunology. 2001; 14(1); 31-47. [PubMed: 11270595].

Gene Information

Gene Name

VP2

Protein Information

NCBI Protein GI

431460

Protein pI

5.78

Protein Weight

97494.97

Protein Length

928

Protein Note

Rotavirus VP2 protein; pfam05087

Protein Sequence

>AAA47305.1 VP2 [Rotavirus sp.]
MAYRKRGARRETNLKQDERMQEKEDSKNINNDSPKSQLSEKVLSKKEEIITDNQEEVKISDEVKKSNKEE
SKQLLEVLKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQAKKQTKLFRIFEPKQLPIYRANG
ERELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLMEMPDYLLLKDMAVENKNSRDAGKVVDSETAAIC
DAIFQDEETEGAVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERI
RNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQK
MSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIADMLSQRTMSLDFVTTNYMSLISGMWLLTVIPNDM
FIRESLVACQLAIINTIVYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNYNQFRQVVIDGV
LNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLSYNYETLM
ACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAA
NRLNLYQKKMKSIVEDFLKRLQIFDVARVPDDQMYRLRDRLRLLPVEIRRLDIFNLIAMNMEQIERASDK
IAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRSGDYAQITNMLLNNQPVALVGALPFITD
SSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWIPTSTTKVYKQVPQQFDFRAS
MHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL

Epitope Information

IEDB Linear Epitope