VIOLIN: Vaccine Investigation and Online Information Network

VP4

General Information

Protegen ID

675

Sequence Strain (Species/Organism)

Murine rotavirus

VO ID

VO_0011255

Taxonomy ID

28327

Other Database IDs

CDD:189541

Molecule Role

Protective antigen

Molecule Role Annotation

Plasmid DNA vaccines encoding for murine rotaviral proteins VP4, VP6, and VP7 were tested in adult BALB/c mice for their ability to induce immune responses and provide protection against rotavirus challenge. Vaccines encoding VP4 were effective in protecting mice against infection after rotavirus (100 ID50) challenge (Herrmann et al., 1996).

References

Herrmann et al., 1996: Herrmann JE, Chen SC, Fynan EF, Santoro JC, Greenberg HB, Robinson HL. DNA vaccines against rotavirus infections. Archives of virology. Supplementum. 1996; 12; 207-215. [PubMed: 9015117].

Gene Information

Gene Name

VP4

Protein Information

Protein Name

VP4

NCBI Protein GI

475695

Protein pI

5.09

Protein Weight

81238.63

Protein Length

822

Protein Note

Outer Capsid protein VP4 (Hemagglutinin); pfam00426

Protein Sequence

>AAA50492.1 VP4 [Murine rotavirus]
MASLIYRQLLTNSFTVDISDEIETIGAEKTQNVTVNPGPFAQTGYAPANWGPGETNDSTTVEPMLDGPYQ
PIAFSPPPEYYILLSPTAPGVIAECTNTVNRWIAIIAIEPNVSTTNRTYTLFGITEQLTVENSSVDKWKF
IDFMKTPTTGSYVRYNILLSSTKLCAVAKHTDNLYSYVGETPTAGQAYYSSFNIFNLTAHCDFYIIPWSQ
QSLCTQYVNNGLPPIQNTRNVVPRHLSARSIITQRAQANEDIVVSKTSLWKEMQFNRDITIRFKFANAII
KSGGLGYKWSEISFKPANYQYTYTRDGEEVTAHTTCSVNGVNNFDFFGGSLPTDFGISRYEVIKENSFVY
IDYWDDSQAFRNMVYVRSLAADLNTVECTGGAYSFSLPVGQWPVMTGGAVSLRAAGVTLSTQFTDFVSLN
SLRFRFRLSVEEPSFSITRTRVSGLYGLPAADPNNGREYYEIAGRFSLISLVPSNDNYQTPIMNSVTVRQ
DLERQLGELREEFNALSQEIALSQLVDLALLPLDMFSMFSGIKATLDVAKSMATNVMKKFKKSGLATSIS
AMTESLSDAASSVSRSGAIRSVSSTSSAWTDVSSRVANVENAASTVSTQTATISRRLRLKEITTQTEGMN
FDDISAAVLKTKLDKSVQIAPNTLPDIVTEASEKFIPNRSYRVINNNEAFETGTDGRFFAYRVDTLEELP
FDVQKFADLVAESPVISAIIDFKTLKNLNDNYGISKEQAFSLLRSDPRVLREFINQGNPIIRNRIEQLIM
QCRL

Epitope Information

IEDB Linear Epitope