VIOLIN: Vaccine Investigation and Online Information Network

VP7

General Information

Protegen ID

676

Sequence Strain (Species/Organism)

Murine rotavirus

VO ID

VO_0011256

Taxonomy ID

28327

Other Database IDs

CDD:278842

Molecule Role

Protective antigen

Molecule Role Annotation

Plasmid DNA vaccines encoding for murine rotaviral proteins VP4, VP6, and VP7 were tested in adult BALB/c mice for their ability to induce immune responses and provide protection against rotavirus challenge. Vaccines encoding VP7 were effective in protecting mice against infection after rotavirus (100 ID50) challenge (Herrmann et al., 1996).

Related Vaccines(s)

HSVT[VP7/6/2]

References

Herrmann et al., 1996: Herrmann JE, Chen SC, Fynan EF, Santoro JC, Greenberg HB, Robinson HL. DNA vaccines against rotavirus infections. Archives of virology. Supplementum. 1996; 12; 207-215. [PubMed: 9015117].

Gene Information

Gene Name

VP7

Protein Information

Protein Name

VP7

NCBI Protein GI

475697

Protein pI

4.84

Protein Weight

35471.05

Protein Length

367

Protein Note

Glycoprotein VP7; pfam00434

Protein Sequence

>AAA50493.1 VP7 [Murine rotavirus]
MYGIEYTTALTFLISFLLLRYILKSVVKIMDFIVYRFLFVILILSPCIKAQNYGINLPITGSMDTAYANS
TQPETFLTSTLCLYYPKEAATEIKDNSWKDTLSQLFLTKGWPIGSVYFKEYTDIAAFSIDPQLYCDYNVV
LMKYDASLQMDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIRVCPLNTQTLGIGCLTT
DVTTFEEIATAEKLAITDVVDGVSHKLNVTTATCTIRNCKKLGPRENVAVIQVGGSDIIDITADPTTAPQ
TERMMRINWKKWWQVFYTVVDYVNQIISTMSKRSRSLNSAAFYYRV

Epitope Information

IEDB Linear Epitope