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VP6

General Information
Protegen ID 677
Sequence Strain (Species/Organism) Rotavirus A
VO ID VO_0011257
Taxonomy ID 28875
Molecule Role Protective antigen
Molecule Role Annotation VP6 derived from Group A rotavirus conferred in vivo partial protection against rotavirus challenge in a neonatal mouse model (Garaicoechea et al., 2008).
References
Garaicoechea et al., 2008: Garaicoechea L, Olichon A, Marcoppido G, Wigdorovitz A, Mozgovoj M, Saif L, Surrey T, Parreño V. Llama-derived single-chain antibody fragments directed to rotavirus VP6 protein possess broad neutralizing activity in vitro and confer protection against diarrhea in mice. Journal of virology. 2008; 82(19); 9753-9764. [PubMed: 18632867].
Gene Information
Gene Name VP6
NCBI Gene ID 7011372
Genbank Accession DQ838646
Locus Tag RVA_s6gp1
Segment No 6
Gene Starting Position 23
Gene Ending Position 1216
DNA Sequence 
>NC_011509.2:23-1216 Rotavirus A segment 6, complete genome
CATGGATGTCCTATACTCTTTGTCAAAGACTCTTAAAGACGCTAGAGACAAAATTGTCGAAGGCACATTG
TATTCTAACGTGAGTGATCTAATTCAACAATTTAATCAAATGATAATTACTATGAATGGAAATGAATTTC
AAACTGGAGGAATCGGTAATTTGCCAATTAGAAACTGGAATTTTAATTTCGGGTTACTTGGAACAACTTT
GCTGAACTTAGACGCTAATTATGTTGAAACGGCAAGAAATACAATTGATTATTTCGTGGATTTTGTAGAC
AATGTATGCATGGATGAGATGGTTAGAGAATCACAAAGGAACGGAATTGCACCTCAATCAGACTCGCTAA
GAAAGCTGTCAGCCATTAAATTCAAAAGAATAAATTTTGATAATTCGTCGGAATACATAGAAAACTGGAA
TTTGCAAAATAGAAGACAGAGGACAGGTTTCACTTTTCATAAACCAAACATTTTTCCTTATTCAGCATCA
TTTACACTAAATAGATCACAACCCGCTCATGATAATTTGATGGGCACAATGTGGTTAAACGCAGGATCGG
AAATTCAAGTCGCTGGATTTGACTACTCATGTGCTATTAACGCACCAGCCAATATACAACAATTTGAGCA
TATTGTGCCACTCCGAAGAGTGTTAACTACAGCTACGATAACTCTTCTACCAGACGCGGAAAGGTTTAGT
TTTCCAAGAGTGATCAATTCAGCTGACGGGGCAACTACATGGTTTTTCAACCCAGTGATTCTCAGGCCGA
ATAACGTTGAAGTGGAGTTTCTATTGAATGGACAGATAATAAACACTTATCAAGCAAGATTTGGAACTAT
CGTAGCTAGAAATTTTGATACTATTAGACTATCATTCCAGTTAATGAGACCACCAAACATGACACCAGCA
GTAGCAGTACTATTCCCGAATGCACAGCCATTCGAACATCATGCAACAGTGGGATTGACACTTAGAATTG
AGTCTGCAGTTTGTGAGTCTGTACTCGCCGATGCAAGTGAAACTCTATTAGCAAATGTAACATCCGTTAG
GCAAGAGTACGCAATACCAGTTGGACCAGTCTTTCCACCAGGTATGAACTGGACTGATTTAATCACCAAT
TATTCACCGTCTAGGGAGGACAATTTGCAACGCGTATTTACAGTGGCTTCCATTAGAAGCATGCTCATTA
AATG
Protein Information
Protein Name VP6
NCBI Protein GI 210136699
Protein Accession YP_002302229
Protein pI 6.05
Protein Weight 42193.23
Protein Length 397
Protein Sequence 
>YP_002302229.1 VP6 [Rotavirus A]
MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFNFGLLGTTL
LNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSAIKFKRINFDNSSEYIENWN
LQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEH
IVPLRRVLTTATITLLPDAERFSFPRVINSADGATTWFFNPVILRPNNVEVEFLLNGQIINTYQARFGTI
VARNFDTIRLSFQLMRPPNMTPAVAVLFPNAQPFEHHATVGLTLRIESAVCESVLADASETLLANVTSVR
QEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLIK
Vaxign Prediction
Localization(Probability)
(Prob.=0)
Adhesin Probability 0.308
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope