VIOLIN: Vaccine Investigation and Online Information Network

VP6

General Information

Protegen ID

678

Sequence Strain (Species/Organism)

Bovine rotavirus

VO ID

VO_0011258

Taxonomy ID

10927

Other Database IDs

CDD:279341

Molecule Role

Protective antigen

Molecule Role Annotation

Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system. Challenge of neonates born to animals immunized with VP6 protein showed partial protection (Redmond et al., 1993).

Related Vaccines(s)

Rotavirus VP4/VP7 Protein Vaccine

References

Redmond et al., 1993: Redmond MJ, Ijaz MK, Parker MD, Sabara MI, Dent D, Gibbons E, Babiuk LA. Assembly of recombinant rotavirus proteins into virus-like particles and assessment of vaccine potential. Vaccine. 1993; 11(2); 273-281. [PubMed: 8382422].

Gene Information

Gene Name

VP6

Protein Information

Protein Name

VP6

NCBI Protein GI

195661002

3D structure: PDB ID

1QHD

Protein pI

5.72

Protein Weight

42501.43

Protein Length

439

Protein Note

Rotavirus major capsid protein VP6; pfam00980

Protein Sequence

>ACG50679.1 VP6 [Bovine rotavirus]
MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTL
LNLDANYVETARNTIDYFVDFVDNVCIDEMVRESQRNGIAPQSDSLRKLSGIKFKRINFDNSSEYIENWN
LQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEH
VVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVILRPNNVEVEFLLNGQIINTYQARFGTI
IARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEHHATVGLTLRIESAVCESVLADASETMLANVTSVR
QEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK

Epitope Information

IEDB Linear Epitope