On the basis of the experimentally determined B cell epitopes of Phl p 1, five synthetic peptides have been synthesized. These peptides are derived from the major Phl p 1 IgE epitopes and were between 28-32 amino acids long. When used as immunogens in mice and rabbits, the peptides induced protective IgG antibodies, which recognized the complete Phl p 1 wild-type allergen and group 1 allergens from other grass species. Moreover, peptide-induced antibodies inhibited the binding of grass pollen allergic patients IgE antibodies to the wild-type allergen (Focke et al., 2001).
References
Focke et al., 2001: Focke M, Mahler V, Ball T, Sperr WR, Majlesi Y, Valent P, Kraft D, Valenta R. Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2001; 15(11); 2042-2044. [PubMed: 11511525].
