VIOLIN: Vaccine Investigation and Online Information Network

Tbx21

General Information

Protegen ID

695

Sequence Strain (Species/Organism)

Mus musculus

Taxonomy ID

10090

Molecule Role

Protective antigen

Molecule Role Annotation

Study explored the role of intranasal delivery of T-bet on the differentiation of T(H) cell subsets and airway inflammation in the ovalbumin (OVA)-induced mouse model of allergic airway inflammation. Intranasal administration of AAV-T-bet efficiently balanced the T(H)1/T(H)2 transcription factor and cytokine profile and significantly decreased the number of eosinophils in BAL fluid. It also resulted in a reduction of peribronchial inflammation scores and serum IgE levels in OVA-sensitized and challenged mice during the effector phase, and inhibited airway inflammation during the challenge phase in a mouse model of allergic airway inflammation (Wang et al., 2008).

References

Wang et al., 2008: Wang SY, Yang M, Xu XP, Qiu GF, Ma J, Wang SJ, Huang XX, Xu HX. Intranasal delivery of T-bet modulates the profile of helper T cell immune responses in experimental asthma. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologia. 2008; 18(5); 357-365. [PubMed: 18973099].

Gene Information

Gene Name

Tbx21

NCBI Gene ID

57765

Genbank Accession

AL606664

Chromosome No

Locus Tag

RP23-428N4.9

Gene Starting Position

97098006

Gene Ending Position

97115330

DNA Sequence

>NC_000077.6:97098006-97115330 Mus musculus strain C57BL/6J chromosome 11, GRCm38.p4 C57BL/6J
TAGATCAGCAAACTTTGATCCACACACACACACCTCCTACCGACCAGCCACAGAAGGAGGGCGTGTTTAC
CAGGTCCATGTTTATTTCCAGAAAGTGATGCAAAACAGAAGAAATACATCCAGACACCACTCTCTACAAT
AAATAGCCTCCCCCCTCCCGAAGAAATAAAAAAGAGACACCCGTGTGTGTACACACCGGTTCAAAGTGAC
CTCGCCTGGTGAAATGTGCACCCTTCAAACCCTTCCTCTGCACCCACCCTCTCTTGTCTCCTCGCAGGTG
GCCCAGTCCGCCCGCAGTCACCTGAGTCTTCTCTGTTTGGCTGGCTGTTGTAAAAATGCGTGTATCTTCA
CTTTCAGGTCAGAGATTAACACAGGTGTCAGACCAACAGTTGAAAGTTACTGACTGGACAGGGGAAGAGA
GCAGCTCTCCTGGACTCCCCACCCCGACCCCTCCACCTCGCAGAAAGCCATGAAGTCCCTCTGGGTCCAA
AACTCTCTGGAGTCCATTCTCCGTTCTCCATGGAACCATGGGGTCAGAAGCAGCACCAGGTTCGTGACTG
TAGTTCGGGCAGAGAAAGGGGCAGGGGACACTCCTGTCGTATTTCCTTGTGGGCCAGGAAACAAGAAGTA
AACCCCAGAATCCTTCTTGCCCCGCTTCCTCTCCAACCAATCACTATACAGGGAAGGGATGGGGAAGAGC
TCGGGGCTCTCAGCCCCGCGTCTGTTTTCTAAGTTAGTGGGCACCTTCCAATTCAGCGGCATTTTCTCAG
TTGGGAAAATAATTATAAAACTGGCCTTCGGTTTCCTTATCAAAAGGAGAAGGGGCCCCAGCGGGAGAGG
AGCTGTCGCCACTGGAAGGATAGGGGGATATCCTCCTCCTCTTAGTGTCTCCTTCGCCTAGTCCTGAGTC
GCTGGGCTCCGGCTGGAGGGAGGTGACCTCAGGCCACAGCGAGGGGGAGGAGCCCTGTTCCTCTGAGGAT
CCCAGGCCCGGGTCCATGGGCAGAGTTCGCATGGGCCGGAACCAGCCAGCTGGGCTCATCTTGGGCGGGT
ATTGAGGGGCCACGGGCCAACCAGCTCCAGGCGCCAGGACGTCTTGGCCCCGGTAGTAGGGCACAGTGGG
CCCCGGGGCAGAGGGTAGGAGTGTGGGCTTCATGCTCACAGCTCGGAACTCCGCTTCATAACTGTGTTCC
CGAGGTGTCCCCAGCCAGTAAGGCTGTGAGATCATATCCTTGGGCTGGCCTGGAAGGTCGGGGTAGAAAC
GGCTGGGAACAGGATACTGGTTGGATAGAAGAGGTGAGAAGGGGTCTCCCCCAAGCAGTTGACAGTTGGG
TCCAGGTGGCGAGGGGACACTCGTATCAACAGATGCGTACATGCTAAAAAATAAATAAAAATAAAAACAA
TGAATGAGGGGGCTAGAGAGATGGCTCAGCAGTTAAGAGCACTGGCTGCTTGCTCTTCCAGAGGTCCTGA
GTTCAATTCCCAACAACCACATGGTGGCTCACAGCCGTCTGTAATGAGATCCAATGCCCTCTTCTGGTGT
GTCTGAAGACAGCTACTGTGTACTCGTATAAATAAAATAAATACAGAGAGACAGAGACAGAGAGAGACAG
AGAGAGACAGAGAGAGAGAAAGAGAGATCAAGGCTATATTAGGCTTCTAATATGATGGTCCCCAGACCCC
TGAAGCAGAGACAGGGCATGTTGAGCACTGAACCACAGTCCCATCTCAGAAAGACCAAAGGGGATTTGAA
CTCAGAACACTTACGACTCAAAGTTCTCCCGGAATCCTTTGGCAAAGGGGTTGTTGTCGATTTTCAGCTG
AGTGATCTAGAGACGGGGAAATAGAGTTCTCTGAGTCCCCTCTTCCTCCTCAAGAAGTCTGTCCCACCCT
CCCTCTGGCAGATGCCCGTCCCCGGGCTCACCTCTGCGTTCTGGTAGGCAGTCACTGCAATGAACTGGGT
CTCTTGGAAAGTAAAGACGTGTGTGTTAGAAGCACTGCAGGCAGCCTCTGGCTCTCCATCATTCACCTCC
ACGATGTGCAGCCGGGGCTGGTACTTGTGGAGAGACTGCAGGACGATCATCTGGAGAGGGGCCAGGGGGT
GACAGGGTCACGGAAGGAGCTGGAAGGAAGGTCCTCCTGACCTCAAGCTGGCCTCATCTCTAGATGCACT
CTCCTACGTAACTACTAGCCCCACAGTGAGACAGACTAGAAAGGATGCCTGAGTTCATCTTGTGGCTTCG
ACCACCTTACCACCATGCAACTTCCCCTAAGCATCCCTACTGGAACTCACCAAGTAGGCTGGCTGGCCAG
TGAGCCCTAGGGATCCACCTGTGTCCCCGCCACCCGCTCCCAGTGTTTAAATAACTGGTTCATGCCATTA
CAACTGGCTTTTCTTTTCTCTTTTAACCTAGGTTCTAGGGATGAAACTCAGGTCTTTGTCTTTCAAGGGA
AACACTTTACCAACTGAATCTTCTCTCCAGCTCCAGGTTTTGTTTTGTTGTTTAATTTAAAAAAACAAAA
AACAAAAAAACAAAACAGGACTGGGTCTGTGGAGATGGCTCATCAGATAAAGGCATTTGCTGCCAAGCCT
GGCGACCTGAGTTTGATCCCTGGGATCCACGTGGTAGAAAAAGGGAATCAACTTCAGCAAGTTGTCCTCT
GACCTCCACAAACACATCATAGCAACTTACTCCCCCACAACTAACTAACTGAGTAACTTACTAAGTAAAT
AACTACATAAGTAGATAGATGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGA
TAGATAGATGGATGGATGGATGGATGGATAGATGGATGGATGGATAGATGGATAAATGGATGGATGGATG
GATGGATGGATGGATAGATGGATGGATGGATAGATGGATAAATGGATGGATGGATGGATGGATGGATGGA
TGGATGGATGGATGAAGTAAATGTGTAAAACAAACCAAAACAAGACCCATAATTGTTCAATGTAAAGTCA
CTTTCACACTGAACATCCATTCCCTGAAGCTCTAGGACCATCTCGGTGACAGATCATGATCTAGTGAAGA
AGCCCTCATGTTGTTCTGACTTGTGTTGACCCAGGAGCAACCACTGCCAGAGATCCAGTGTCCACCCATC
TCATTGTCTCCCAAAGATGGGTAGGAAAGACTCATAGAGAGGAAGAAAAGGAGCCGGGGCATAGAGCAGC
TCAATTGCTAGCACCTTTGTCTAGTCTGGTGCAATATCTGATTGAACCACATCAATCAGGCCTGGTGGTG
CATGCCTGTGATCTCACCCTCAGGAGCAGATGGAACAGAAGTTCATGGTTATCCTTGGCTATGTAGGGAA
GAGAGGAGAAGAGGAGAGGAGAGGAGACGAGACTCCAACAGTACAAAGTGGGTCTTAGGAAATGTCAGGG
GGTAGATCTCAGACATATAGGCAGGTGGGTCTGACAATCCTACCTGGGTCACATTGTTGGAAGCCCCCTT
GTTGTTGGTGAGCTTTAGCTTCCCAAATGAAACTTCCTGGCGCATCCAGTGGGCTCCGGTGTTGGGGGAG
TCTGGGTGGACATATAAGCGGTTCCCTGTGGACAGTTAACCTTATTGTCAAGTATCGACCAGACACTGGA
GATGTGGGATTTTGCCTCTTCTGAGTGGACCGTGAGAAAGATGCAAGGGAGAGGACAGACAGGCTGAGCA
GGGGCAGATAAGGGCAGAGGACTGAGCAGAGTGAGTCTCTTTCTCCCTCCCCCACTCCCCACCTCAGTTA
AATCAAATTAGAGAAGAGGTAAGAAGCCAAAGGAAGGGTGAGGTGGGTGGATAGGCTGTAGGGTTCAATC
CTTCACATCGGGGTAAGGGCTTGAGTAATCCACCAGGGGGCGCCCTGTCTAGGAGGAAACGCATGCCCAC
CACTCCCGAAGCTTGTACCTGGCATGCTGCCTTCTGCCTTTCCACACTGCACCCACTTGCCGCTCTGGTA
CCGCCAGTGGTGCTGGTCCACCAAGACCACATCCACAAACATCCTGTAATGGCTTGTGGGCTCCAGCCCG
GCCACGGTGAAGGACAGGAATGGGAACATTCGCCTGTGGGGAACAGAGAAGTTCCAGGGACCATCAGCCA
GGGCTCAGTGGCAGTCACCTGTGTGCATGTGTCAAGCTGTAGCCGGCCTTCACTTGTCCTCAAGAGCCAA
CTGACAAGTGTGTCAGAAGGTAGCTAGCTTGTTAGTTATTAAATATAGATGTAGGCTGGAGAGATGGCTC
AGCGGTTAAGAGCACTGACTGCTCTTCCGGAGAGCATGAGTTCAATTCCCAGCAACCACATGGTGGCTCA
CAACCATCTGTAATGGGATCTGTAGTCCTCTTATGGTGTGTCTGAAGACAGCTGCAGTGTAATCATATAT
GAAATAAATAAATAAATAAATTTAAATATACGTGTGTGTGTCTGTGTGTGTGTAACAGAAAATTAATTCA
TAGGACTGAAGAAATGGCTCAATGGTTAAGAGCATATAGTGTTCTTCCAGGGGGACTGAGTTCAGTTCTC
AGCACCCACGTCAGCTTACAACAGTCTTTAACTCCAGCTCCAAGGTGATCCAATGCCTCTGGATTCCACT
GACACCCACATGTCCATACACACACACACACACACACACACACACACACAAAATTAATAATATATCTTTT
TTTTTTTTGAGACAGAGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAGCTCACTTTGTAGACCAGGCTGGC
CTCGAACTCAGAAATCCACCTGCCTCTGCCTCCCAAATGCTGGGATCAAAGGCGTGCGCCACCACGCCCA
GCAATACATCTTTTTTTTAAAGTTAAATTGCACTAGCCAGTGTGGTAGAACACATCTTTAATCTTAGCAC
CTAAGAGCAGAGGCAGGAGGATCGCTGAGTTTGAGGCCAGCCTGGTCTATAAAACCAAGTCTCAGGATAG
CCAGGACTACACAGAGATACCCTGTCCTGAAAAACAAAACAAAAACAAAAACAAAATTAAATTGTTCACA
CTTAACAATAATCACGTTCTACCAAAAGCCAAGGTACACACAACCCAAGAGTCTCTTCTCAGTGCTCTGA
CGTGTTGTACTGTGGCCCCGGCTTGAGCTTACTTGTGTCTTTGTCTGAGGCAGCTGAAGAACAGAGACAA
TGGCTACTGTGCATTGCCCCCAATTCTGTGTTCAACCCTGTCATGTTGGTAGCTTAGAGTCAGCTGCAGG
GCACCAGCAGACACAGTAAATCAGTGCCTACCCCTCTGTACTGCTGCTGATTAAACCCAAGGCTTAATGC
ATGATGGGCAAGCACTCTACCACTGAGCCACATCCCAGCCTGCAGACTTTTGATAACGCTTTCCTCTCAA
AAGATCAGTTACTAGATAATTATCTGGAAACCACTGTCTCTAACATTAGTGAGCTTCCTGCATGGGCCAA
AGGCACCAGGCAACCCTTTAAAGATAGTCCCAGAAGGTGGGTGTGCCTGAGTTCCACAGCTCCACCATGA
CTCTCCCGCTCTGCAACACACTCCTGCCCCATGGAAGTCACTGACAGGTCCTCTCTGTCCCACACTCCAG
TCACATCTATAGTGTGCCCTGCCCCAAGTCTGGCCTTCAGAAACTCATCAAACACCCTAGGCATCCTGAA
GGCTCTAATCGTTCTTATGCTTAGTCTTGGGTCCCAGGAAAAGCAGAAGTTGGTGGGTGGGTGGGATCCT
GCATGACCCTCCCTTGTTCTAAAGTGAAAGCATCAGAAAAGGGAACGCTCTCCTGCAAAGGCCTCCCCAC
CACTTCCACCATGGCTGCCCCCCATTATCACGATCATGACAACCACCACCTCCATATCACAACCACTATC
ATTCTCACCGCTATCTCCACCATCACGGTGACACCGTCTCTACCAGTACAACCTCCAGGGTTGTTACTGT
CACTTCCACAATCATTGCCGTTGCCATTACCATGATTACAGCTATGTTGTCTCCAGCCACCACCTCCACC
CCACCACCACCACCAATACAGCCACCATGTCCACCATAATACAGACACCGCTACCTCCATCTCTACAGAC
ACCACCTCCACCACATCTGCAGCTACCATCTCTACAATCTTATTAATATATCCATCGATTTCACCATGTC
TTCTATCTCTCAAACCACCACCTCCGTCAAAGCCACCACTCCCACCCTCACTCTGGCTACGCCTCCGCCA
TGACCATGGCCATCGTCACTCCCGTCACCACACCCACCATCTCCATCATAGTTACAGCCACTGACTCACA
GTTGCCATTACGCTAGTCTTGACTTTCATTATCACCATCACAGCCGTCTTGTCTCCAAGCGCTACCATCA
CCATCTCTTCTGTCCACTCTAGCCACAGCCTTCACTGCCACAGCCACCATGCCCAGTCTCTGCATCACCA
GTTCCAATGACTGAGCTCTGCCTTTGTGCCCCAGCTGGGAGTGGGGAGGGGGCGGGGAGAGCGGTGTGGT
CAGAACAACAGATTCAAACACTCACTGGACATCCCTTTAGGTCCCACATCCCACCTCTCAGGGAGCCACA
TGGGATAGGAAAGCTTTTGTCTCTTAATCAAGAAACCTATAGACTAGAGGAGCCTCAAACTCACAATGTA
GCTAAGGATGACTGAATTTTCCTGCCTCAACTTCCAAAGTGCAAGGATTAGGGTGCACACCACTATACCC
AGTTTGTGTAGTGTTAGGGATCCACCTAAGACATAGTGAATTTTAGACAAGAATCCTACCAGCTTTGCTA
CATCCCTAGACCAAGAGCTAAGTATGGAAAACCCGAGGTGGGGAGAATATTTTCAATCCATTTCCCTCAC
CCATTCACTTTAAGCCATTCAGATTGTAGTTTCTGAAATTGAAGCGCTTAATGCTCTTCTGTAGATCAGG
GTTTGGTTCCCAGAACCACACCAGGCAGCTCACAAGTTGTCTGTAACTCTACAGGAGATTCAACAGGCCC
TGGCCTACACAAGAACCTGCACACATACGGTGCACATAAACTCACAAAAGCACACATACATGTAGATAAA
AATAAGTTTAAAAAATAGGGAGTTGGGCATGGTGGTGCATGTCTTTATTAATATTTGTTGCTTTTAAAAA
ACATTTTAGACTTTATTTTATTTTATTTTATTTTATATATGAGTGCTCTGCTGCATGTTCACCTGCAGGC
CAGAAAAGGGCATCAGATCTCTCTATAGATGGTCATGAACCACCATGTGGTTGCTGAGAGTTGAAATGAG
GACCCCTGGGAAAGCAGCCAGTCAGTACTCTTAGCCATTAGACACCTCTCCTGCCCTGTTTCTTTTTCAA
GACAAGGTTTCTCTGTGTAACCCTGGCTGTCCTGGAACTTGTTATGTAGACCAGACTGGTCTCAAACTTA
GAGATCCACCTGGGTCTACCTCCCAAATGCTGGGATTAAAGGTGTGTGTCACCACTGCCTAGCTTGCTTG
CTTATTTATTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTGGTTTTTCGAGACAGGGTTT
CTCTGAGTAGCCCTGGCTGTCCTGGAACTCACTCTGTAGATCAGACTGGTCTCGAACTCAGAAATCTGCT
TGCCTCTCCTCCCAAGTGCTGGGATTAAAAGTGTGCGCCACCACTGCCTAGCGTATTTTATTATTTTGAA
GCAGGGTTTCATATGTAATTCTGGCTATCCTAGAATTTGCTATGTGAGCCAGGCTGGCCTCTGACCCACA
GAGGTCCACCCACCATGCCTGGCTTGGCACTTGTCTTTAATCCCAGCACTCAGGAGGGAAAGGCAAATGG
ATCTCCATGAGTCTGAGGCCAGCCTGGTCTACGTATGCAGTTCTAGGGTAGCTAGAGCTACGGGACAGGG
AGACTCTGTCTTAAGAGGGTAAGGTGGCTGGAGAGATGGCTCTGCTTTCCCAGACGACCTGGGCTTGATT
CTCCACACCCACATGATGGGCCACAACTACCTGTAACACATGCATGAAGACGTAACATTCATACACATAA
AAAAACATAAAACATATATATTTTCTTACCTAGTGACCAGGTCTCATTCATATTTTCTATTCTAAAGGAA
CAGAATAGCAAACACCTTTTTGGTGCCAAATATAGAACCCAGGGCCTCGCGGATGTTAGGCTAGGGCCCT
GCCACTAAGCCCCATACCCAGCCTCATACTATGTTTATCCATCCTCCACTTACGCACAAGCCAACTCATC
AAGACAGTCCTTGGAGAAACAAAACGTCTTGAAACTCTACACCTGAAGACACTGAAGCTTATAGAGAGAT
TGATGAATACCCCACACTACGGTTTCTGTCCATCTGTCCTACTGTTGTCCCGATAGTGGGTGACAAAAGA
TACAGGAAGATTGTAAGTGAAAGGCAAAGGAGGGGGGGTCTTAGTTTCACTTTAAAAGATGGCGAGATGC
TGCACAATCACGAAGACATGAGTACCCAGTGCCCACACTGAAGAGGAGGAGGAGGAGAAGAGGAAGAGGC
AGCCTGGTGTGGTGACATCTGGTGTGGTGACATCTACTTAGAATTCCAAAACTGGGGAAGCAGAGACATT
TAGATTCTTGTCAACCAGCCTAGCCTTCTTGGTAGACTCTAGGCTAATGAGACCCTGTCTCAAAAATAAA
CAAACAAACAAATTAATTAATAAATGAACCAAGCATGCTGGCGCATGCCTTTAATCCCAGAATTTGAGAG
GCAGAGGCAGATCACTGTGAGTTTGAAGCCAGCCTACATATAGAGATTCTGGAGAGAGAGACAGAGAAAG
AGAGACACAGAGAGACAGACAGACAGACAGACAGACAGACAGACAGACAGAGAGGATTCCAGAGGAATGA
CTTTCAAGGTTAACTAATGGCCTTTACACAAATGTTCACACTTGTACATGTACATACACACACACACACA
CACACACACATATGCACACACACTACTGAAATAACCAGCAGCTAGAATCCCCAAATAGCTCCCTGATCTA
CATGTTGCTTTACTAAGAAGAAACCAGTAGTGGAGATGAATCTGCTACCAAGTTGACCTCCTTAAAACTA
CTTACAGAGTCAAGATCCCATGACTCTCTGCTGCCCCAAGGCTAACCCGCCTAGCGATGATTTTTACACG
GCTGTGGGACATGGCAGGGAACATAGTGAGTTCTAGGCCAGACAAGGCTACACAGTGAGACACTGTCTCC
AACAACAAAGCAATGACTAGTTTCAGACATCAATCAACTTTCCATGGGATTGACCAGCTGAGTCCTCCTC
AGAGCAGGTAAAGAACAGCTAGGCTTTTCTGAGTAGCCGTTTCCAAGAGATTTTGAGATTCTTAGTCCAT
GGGCCCAGACTCTGGAGGAGGAGAAAGAGGACTCTTGAAACAAGTGTTTTGTAAAGATGTGAGAAGTTAA
ATTGGGGTCGCAACTCAGTATAGGAGTGCATGTTTAGGGTTTGGCGAGGCAGCTCAGGGTTAAGAGCACT
GGCTGCTCTTCCAGAAGATCCAAGTTCTATTCCTAGCACCCACATGGCGGCTCACAAGTATCTGTATCTC
CCGTTCCAGGGGATCTGACACCCTGATACAGAGATACATGCAGGCAAAACATCAAAGTACTTAAAAAATA
AAAAAAAAAATTAAAAAAAAAACCATTGATTGCCTAGCATCCATGAGACCCTGGGTTTAATATAGCACCA
CCAACAACAAAAAATCCATGGGTGGAGAGGTGGCTCAGCAATTAAATGCACTTGTTTTGGGGGCTGGAGA
GATGGTGTACCACTTAAGAGCACTGGCTGCTCTTCTAAGAGGACCTAGTTTCAATTCCAAGCACCCACAT
GGCAGCTTACCCCTGTCTGTAACTCCTGTTTCAAGGGATCCAGCACTCAACACAGACATACATGTAGGCA
AAACACCGATGTACATAAAATAAAAATAAATATTTTTTTTTGTTTTTAAAGAAGCACTTATAGCCGGGTG
TGGTGGTGCACGCCTTTAATCCCAGCACTCAGGAGGCAGAGGCAGGTGGATCTCTGAGTTCGGGGCCAGC
CTGGTCTACAGAGTGAGTTTCAGGACAGCCAGGGCTACATAGAGAAACCCTGTCTCATAACAAAACAAAA
AAAAAAAAAAGAAGCACTTGTTCTTGCAGAGGATTTGGGTTCAATACCCAGAGCCCACACACATGGTGGC
TCACAACTACCTATAACTCTGCCTTCAACATCATCTTCTGACTTCTGAGCACACCAGACATGCATGTTGT
GTACAGACATACATACACATGAGCAAAGCATTCATTCATTAGATGAGTAATTATTAAACATTCGATTTTA
TAATTCCAAACATTAGATTTACAAATAAAATAAATCTAAATTAAAAAAAAAAAGTCTGAAAGCTTAGTGG
GATACAGTGTCTTACACTTAAAATCTCAGCACTTAGGAACCTGAGGCAAAAGGTGTGCTGCACATTCAAG
GGTAACCTGGATACAGGGAGCTCAAGGCTAGCCTGGAGTGAGCCTCTGTCTTACCAAAAGAGAAAAAGAA
ATGAAAGACTGGAGAGATGGCTCAGTGGCTAAAAATACATTCTGCCCTTACAGAGGACCCATAATTGACA
TCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTTTTTCGAGACAGGATTTCTCTGTATAGC
CCTGGCTGTCCTGGAACTCACTTTGTAGACCAGGCTGGCCTCAAACTCAGAAATCTGCCTGCCTTTGCCT
CCCGAGTGCTGGGATTAAAGGCGTGCGCCACCACGCCTGCTGTACTAGACTTCTCTATAGGCTCCATACC
ACCTATATAATTCCAGTTCCAGGAGCTCTGACCTCCAATCTCTATAGGCTCCTCCATACTCATAGCATAT
ACATGATCCCTCCCACACACATATACTCATAAAAACATATTTAAAAAGTAAAAGTAATTTTAGAAGTAAA
ATAATAAGTAAAAAAAAAAAAGTAATTAAAAATTTCGAGAGTTGAGACGATGGGGAAAAGACACTAAGGC
GCTGTGGCACTACCTCACATGAAGTAGGAAGCGCCTTCGCCACCCGGACGTCACATAACCAAGCGCATCT
GCAAACCGAGCTACTTAACACCAGCTCTCCCCAAAGTTATCTTAATTATAATAATCAACCAATCACAGCC
AGAAAAGTGGGGATTACCAGCAATTAGTACCCACCCACACGCCCACGGGGACCGGCCTCTCTTGCCTACT
GAGAAAGCCTTTCGTCCTACGGCTATTATTTGTATTTACCATTCACTACACACTGACTGGCTCAGCCTGC
ACGCAGTGCTCCCGGGTTGCTCCAAAAGTGCACCAAGGAGACTCCAGACTCTTCTTCCTGTTTGTTTGTT
TGTTTGTTTGTTTGTTTGTTTTTAAGGTATTATATCTAATAGAAAGGTGGTGGCACATGCCTTTAATCCC
ATCACTTGGGAGGCAGAGACAGGCAGATGTCTGAGTTCAAGGCCACCCTGGTCTACAGAGAGAGTTCCAG
GGCAGCCTGTCTCAAAATCCCTGGTAGGGGGAACCAAAGAAAAAGACAAGTATTACATTTTATTATTTTT
ATTCTGTAGGGAGGTGTATGCCTGCGTGTTGGGGTAACCTACTCCGCACGAGTATGTGGGGGGATCTGAA
CTCAGTTTGTCAGGATTACAGGAAGCACCCTCACTTCTGAGCCATTTCTCTGGCTCACCTCAAACTCTTC
TTGTGCTCCATTTCCCTCTCTGAGCCCCACTAGAACCGCCCTCATCAGCCGTCATCCCCCTGTTCTTCAC
TCAGAACCAAAAGCATCGCTACCACAGATCCATACTAGTGGGTGAGCCCAGGGTGGGTGGGAGAGGAGGG
ACCAGGGACAGACTGAGTCAGCCCAGGACCAACGGCTGAGGGGCTGTGGCTAGGTCTGGGATGGAAGAAT
TTTTCAAAAAGAAAGAAAGCCGTGGGTGATGTGGTAGTGACTTACAGGTCACTGAAACCTACAGAGGGAC
AGGCCAGCCTGCCAAAGCAGGAGGACTGAAAGGACTCTGCTCTGAGCCCAAAACTCTCAGCAAAAGGAAA
CAGCCAGGACCTCCCAGATAGCTGGAGCTCAAACTTGGAAGATACAGAGGCCACAGGGCTTGGTAAGGCT
GAACTGATGTGGTATTCCCTGTCTGCTTTCCAGGATGGGACCCCTGGGATCTGATCTGAAGAGAGGCATC
AAAGGAAATGATGGGGAGTCACTGCCCCATCCAACAGGGACCCCATGTCATGCAGTGTGGCCTTAGGATC
CAAAATATGAGGATTGCCCCCCCCCACACACACACACATGATGCTAGCACACTCTTATGAAACACTCAGA
AGGCATTTAGGAATTTCTTTTTTAGGTGTGCTAATTGGATTTTTTAAATTATTTATTCATGTGTGTGTGT
GTGTGTGCACTTGCACGTATGTATGTGTGCCCATGTCAATGTAGAAGCCAGAAGACAACTCAGATATAAT
TTCTCAGGCACTGTCTGTCTGTCTGTCTACTCTATCTATCTATCTATCTATCTATCTATCTATCTATCTA
TCTATCTAAACACAAGGGTCTTTCATTGGCCTAAAGGTCTCTGATTACTCTAGGCTGGCTGGCCAGGTAT
TACGAACACCACCATACCTAGGTAATTGGCTATTTTTTTATTTTTTGTTTTTGTTTTGTTTGTTTGTTTG
TTTTTTGAGATGGAGTTTCTCTTTATAGCTCTGGCTGTCCTGGAATTCACTCTGTAGACCTGGCTTTGAA
TTTACACAGATCCACCGGCCAGTCTCTGCCTCATGCCAGGTCCTCACGTTGGCAAAACAAGCACTTCACT
GACTGAGCCATCTCTTCAACCCTGGTTGATTTTTTTGTTTTGTTTTGTTTTTTATTTGTTTTGTTTTGTT
GTTGTTTTTCTTATTTTTACTTTTCTTTTCTTGGATGGTGCAAGTGGTGGACAATACCCACATGTCATAG
TGTATGTTTGGAGTTCAGAGAACAATCTATGGGAGTCAATTCTCTCCTTCAACCATTTGGGCCCTGGCAA
TCAAACCCACAGGGCAATCAAACCCAGGTTGTCAGGTGTGGCAGCAAGTGCCTTTACCCAATGAGCCGTT
TTGCCAGCCCCCCCTTTTTTTTAATTCCACTTTTAAGTCAAGCATGGTTACAGTGCACACTTGTGATCCC
AGCATTCCCGAGGGTGAAGCAGGTGGGTTGAGAATTCCAGGCTAATCTGGAATACATGAATTAAGATCTT
GTCTCAACCGAAATTCATTTTCAGAGAAACATAAAGATTCAAAGCAGAAAGATCAACAATTGCTGACCAA
TCTTGATTGCAAGGCAAGATCCTATCTCAAAATACCCACAAGGTGGCAAATGCCTTTAATGGCAGCACTC
AGGAGGCAAGAACAGAGGAATCTCTATAAGTTCAAGGTTAGCCCCATCTCTATAGTGAGTTCCAGGCCCG
CTGAGCCTGTAGAGTGAGACCCCGAGTCAAAAAGAAAACAAAAACCAAACAAGCAAAATAACTCACAACA
AAAAAGACCAGACCAATACTGAATAGTTTTAAAGCCAAGCCTGATGATATATTTTCTACTTTTATGTTTA
TTTTTGTTTTTTGGGTTTTTGGTCTTGTGTGTTTGTTTGATGTTTTCAAGACAGGGTTTCTCTGTGTAGC
CCTGGCTGTCCTGGAACTCACTTTGTAGACTAAGCTGGCCTCGAACTCACAGAGTTCTGCCTGCCTCTAC
CTCTTGAGTGCTGGGATTGAATGTGCCACCACGCCTGGCCTTTTATTTTTATACAGTGTGATTTGTCATA
ATAAGAAATTGGGCTGGTGAGACGGCTCAGTGGGTAAGAGCACCCGACTGCTCTTCCGAAGGTCCGGAGT
TCAAATCCCATCAACCACATGGTGGCTCACAACCATCTATAACAAGATCTGACACCCTCTTCTGGAGTGT
CTGAAGACAGCTACAGTGTACTTACATATAATAAATAAATAAATCTTAAAAAAAAAAAAAAGAAGTTAAA
GATGTGGCTCAGTAGCAGTGTGACTGTGTGTGCAGAGCACACATAAGGCCCTGGGTTCAATTCTTAGCAT
TGAAAAGTAAACTAGTTTTGATTCCTTGAGACAGAGTGTCAAACATGCGTGGTGGCACATCCTTGTAATC
CCAGCACTGGGGAGGCAGAGGTAGGAAGAGCTGAAGTTCAAAGGAGGCCTTTGCTACATAGCAAAGAGAA
AGAAAGAGGGAGGGGAAAGTTACTATGTAGCACAGGCTAGTTTCCAATTATGCGTGTGCATTACTTAAGG
GGTGCACTACCACAGCTGGCTTTAAAACAAACAAACAAACAAAAAAACATGACTAGTATACACTAGGCCC
CAGGTTCCAATTACAGCACTTAAAATAATAAGAGCACCGATCCAAACGGGAGAGAGCAAAAGTGGTCATG
GGAAAAAAATCCTATAGGCGCACACAGGAGAGGAGTCCATAGAGCCAGGCCAATGATAAAGAGTGTGTCC
CTCCAAATACCTCCCCTAGCAACCCAGCCCACAGACAGACAGGCCCCAGTGATATAGAGTGTGTCCCTCC
AAATGCCTCCCCTAGCAACCCAGCCCACAGACAGACAGGCCCCAGTGATATAGAGTGTGTCCCTCCAAAT
GCCTCCCCTAGCAACCCAGCCCACAGACAGACAGGCCCCAGCCCAGCTCAGCCATCACTGAGGTTGTGGC
TGATGCTCTCTCTGACTGGAGGAGCTGAGGCCTGACAAGGCATTGAGAGGACTGGCCAGGCCCCGGGATG
AGAGGGCCTCCTGTTGCTGACATACTAGAAAGTCCCATGGTTAGAGGCCCCACCTAGTCTACTGCGGGAC
TAGCGTAAGCCACTGGTTATCCCAGCAACTCAGAATTCGTGGGTATGAAACGGGCCAGCCCTGCCTGGCT
CGCCTAGAAATAATGGAAGCGAAAGCACTTGGGTGTACCACGCAGGGCTTTCAGACAGTGTAGGTGGCTG
TGGAGAATGGAGAAAAAAGGAGCAGACAGGTGCCATCTGAGGCCTGGTCCCAGCTGGGGAACCTCCGAAG
AGTCCCCTGCTGTCTCTAGGTCTGTTTCTCTATGCAGTGAGAGACAGGGACTTCTGGATCCTTCCAGTTC
AGACATTCTCTAGGACCAGCAACCTGGCCAGTGCCAGAGACACTCAGAGAAGGATTGGGGGAGCAGAGGA
AACTCCTCAGAAGTCTTTGCGGATGAAGGATGAGCCAAAAACCAATCAAATGTTTTATTCTCAGTTCATC
CCCGCGAGGAAGAACTCAGCAGCCTGAAACCAGCTGTAGTTAGCAGCTATCTGCCCTCTCCCCACATCAT
CCGAAGGGAATATACTCTAGCAGTGCCTCCTGGGATCCGGCAAGGGTTTCTGTCCCCCTCCCAGAAACCC
CACCCTTGCAATCTCTCAATTACATTTTGAGTCTCCATCCTAATACCGCACATCCTAACTCACTAATGGC
AAAGTTCTGGCTGGTCCTCACTGGGAAAGGTAGCTGCCTCTTCCCATAAGACACAAGAGGGTCCACTCGA
GGTGTTGCATACTATAAATGACCCCTCAGAAACTGCAAGTTTCTCTTTCTTCAGCAAAGAGACTCGATCC
GGAAGCAGCAGGCTGAGCCACAAACCATACCACTAATGCAACAGGCTTAGGGGACCCCCTCCATCTTCCC
CCAGGCTGGACTGATGAATAGCTGGGTGAGAAAGTGGACATATTTTTAGGGACTAGCCTCAAAGAGCACA
GTGCAAGACTGGACACCAGCTGCAACTGGTCTTGAACTTGGCACGTTCAGGCCCTCGGCATTTATTTGTG
CCTTTATAAGTTTTGCTGCTTCCCACCTCTCTACACAACACACACACACACACACACACACACACACACA
CACACACTCCTCTCTCTCTCTCTCTCTCTCTCCCTCTCTAGACATATGATCTCAAAGTAAGACCGGAAAA
GAAACTTGGCGACCGCTTCTCCATGTCACCAAATCCCAGTCTGCTCCCCCCCTCCCCCATACACCAAAGC
TACCCTAAGCACAGCAGTAGCAAAGGAACAGGCACACTGAGATCTCAAAAAATATTCTGCCCCCAACACT
TCAATTTCCCGAATACCTAAGGACCGAAAGGCGGTCAGTCAGGTCTATAACACACACTCCTCGCTGCCCA
CTGAGATCCCAGACTGAGGCAAGGAGCAAATTAACCCCCTCCAGTCCCCCACCCCCCACCCCCCACCGGC
CAACTCTCGGTGAAGCGAGAGTCATCCTTTCCTCTGCACCAAAGTAACTTCTAATTGCGCCCACAGCATC
ATCCTTTTTGAGCCCTCTGATACCCTCAGCACCCGCGGCTCTCCGGAGCTTGCGGTGCCCTCCCCGCAAC
CCTGCTCCCCCGTCTCCTAAAACTGAAGCTCAGTCTACGAACACAAAGACTCAGCAACCTGCAGCTTCAA
ATTTTGATTTCAAAAAAAAAAAAAAAAAAAAAGAGGAAAGTCGTTGTTCCGGCGGGCCACCGAGGCCAGA
CTCCCGCCGGCTCCGCCCTGCGAGCTCGCTGCGCTCGGCGCGCACCTCACTCACCGTCCTTGCTTAGTGA
TGATCATCTCTGTCTGGTGCTGGTTGAACTTGGACCACAACAGGTGGTTGCTGAGCGCGACTCTCAGCTT
CCCAGACACCTCCAACCCCGCGGGCAATGCGTAGTCCTCGCGCGGCCCTGGGTAGAGCCCCGCGCGCGGG
TCAGGGGCAGGGTAGCCATCCACGGGCGGGTAGCCCTCCGCACCCGCGGGCGGCGGGAAGAACTCGCCAG
GCCCGGGAAAGCCAGCCACCTGAGCCCGGGGCGGGTAGGCGAAGGATCCAAGGAAGCGACCCGGCGCGGC
AGGCACCAGGGCGCCCCCAGAGTAGGGCGTCCCCAGGCTGCTACCTGCGCGGCGATCGGTCGGGTCCTGT
GCGCCCGGCTCGGGATAGAAGAAACGATGCTGTTGGTCCGCTCCGGGCCCCCGGCCCTCGTCACTCGGCA
TCGGCTCGGTGCCGGTCAGCATGTCTCCGCAGCCCGGCTCCACGATGCCCATCCGAGGCGGGCTGGGCGC
CTTCCAGCAGCCGTCGAAGAGACCCGAGGGTCCTTAGGGCTGGGGCGACGGGGGCGGCGTCCGAAGACCA
ATGAAACTTCACTGGAGCGGGAGCTGGGACGCTTGGCTCCTGAGCGCGCGTTGGATAGGCGCGCAGCTGC
TCCTGGGCTTTCTCTGCAGCCCGCGCTGTCACTAG

Protein Information

Protein Name

T-box 21

NCBI Protein GI

247269497

Protein Accession

NP_062380

Protein pI

5.94

Protein Weight

55072.55

Protein Length

530

Protein Sequence

>NP_062380.2 T-box transcription factor TBX21 [Mus musculus]
MGIVEPGCGDMLTGTEPMPSDEGRGPGADQQHRFFYPEPGAQDPTDRRAGSSLGTPYSGGALVPAAPGRF
LGSFAYPPRAQVAGFPGPGEFFPPPAGAEGYPPVDGYPAPDPRAGLYPGPREDYALPAGLEVSGKLRVAL
SNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAE
GSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPE
AACSASNTHVFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYASVDTSVPSPPGPNCQLLG
GDPFSPLLSNQYPVPSRFYPDLPGQPKDMISQPYWLGTPREHSYEAEFRAVSMKPTLLPSAPGPTVPYYR
GQDVLAPGAGWPVAPQYPPKMSPAGWFRPMRTLPMDPGLGSSEEQGSSPSLWPEVTSLQPEPSDSGLGEG
DTKRRRISPYPSSGDSSSPAGAPSPFDKETEGQFYNYFPN

Epitope Information

IEDB Linear Epitope