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Il25

General Information
Protegen ID 698
Sequence Strain (Species/Organism) Mus musculus
Taxonomy ID 10090
Molecule Role Protective antigen
Molecule Role Annotation Administration of anti-IL-25 mAb during the sensitization phase of a mouse model of allergic airway disease resulted in significantly reduced levels of IL-5 and IL-13 production, eosinophil infiltration, goblet cell hyperplasia, and serum IgE secretion, and prevented allergenic hyper-responsiveness. Even more striking was the ability of anti-IL-25 mAb, administered only during the challenge phase of the response, specifically to prevent AHR even during an ongoing type 2 inflammatory response in the lungs (Ballantyne et al., 2007).
References
Ballantyne et al., 2007: Ballantyne SJ, Barlow JL, Jolin HE, Nath P, Williams AS, Chung KF, Sturton G, Wong SH, McKenzie AN. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. The Journal of allergy and clinical immunology. 2007; 120(6); 1324-1331. [PubMed: 17889290].
Gene Information
Gene Name Il25
NCBI Gene ID 140806
Genbank Accession CH466535
Chromosome No 14
Gene Starting Position 54930309
Gene Ending Position 54935840
DNA Sequence 
>NC_000080.6:54930309-54935840 Mus musculus strain C57BL/6J chromosome 14, GRCm38.p4 C57BL/6J
TCCTCTGGCGTTGGGTACAGAGGCAGAGAAAGAAACCCCAAATGTCTCCTATGAAAAACAATGTCCCCGT
CATCCAGGCCAGATCATTCTGCAGTGTCAACAGTTGAGACAAGAAGCTGGGGTCATTTTCTGTGCCTAAG
AGTGCCTGTTCTGCACTGGCCAAGGTCTGCTTCCTAGGTTGTGCTGGGAGGCAGGGGGGTGGGGGGACTT
ATAGGAATCCTTCTCTTTGAAACAGCACTGCCTGCTAAAGGACCCTACTCTGGGCTTGGGGTTGCTAAGG
AACACCACAAGCCACCTGAGACCACGTGCCAGACAAAAGGCTGGGGAACAGGAAGCTGGAACAATGGATC
CCAGCCAGTGGGGCTGGATGCCAAAGAGGACTGGGATGCCCTGTGGTTTTAGGCAGGTGCAAATGAAACA
CATCCAGTGCCAGTCCGGGGGGGGGGGGGAGCACTGGAGCAAGGGTGGGAGCACTGAGGCAAGGATGGGT
ATGGCACTGGCTGAAGATATTAATGGCCTTATTATTCTTCCCAGGGGAACAGGAACACATTTTCTCTGGG
GGCTCTCCTTCCATTCATAGCCACCTGAGGATTGGCTCATGCTAGAAGCTTATGTTTGGAGTTACTGAGG
GCTGGAATGGAAAAGCCAGCTCAGGTTTTTTTTTTCTAACTACCTAACCCTGAGTAGATGATTGGGGTTG
GGTCTCACTTTCCTCGACCTCAACATGAGGATTTTAGGTTTCATGTCATGGTTTTAGTGTCAGGATAATA
AGAGGATGTGTCTAGGGCTCAGCACCAAGTCTGGCACACTCAAGTGCACAGGAACAAGACCAGCAATGCA
TAAAGGGAAATGGTTTCCAGGAGCACGGGGGGGGGGGGGGCGGGCAGGGCGGGGGGAGCACTGGAGCAAG
GATGGGTGGGAGCACTGGAGCAAGGGTGGGAGCACTGGAGCAAGGGTGGGAGCACTGAGGCAAGGATGGG
TATGACACTGGCTAAAGATACTCCTGGCCTTATTAGTCTTCCCAAGTGTCCTAACGGTGGCCACCAATGG
TTTCTTCTCAGTGCCTCCCACTGTTCCAGGCCCCTAAGATTCACCCAAAGTAGTTTCTTCCAACTTTTGA
GAATGCCCTCTGTCGTCATGACACCGCTGCCTCCAGACTGTGTTGTCCCACAGCGGTCCTGTATGATATG
CATTATTCCTGGCTCCCTTTGTTTACTTTCTGATCCCTTGGTTACTTCAGGAGTATTTTCTGAGGGAAAG
CACATGCAAATCAGCACACATTATTCTAGAGACAGTGTGTATGAGTGTGTTGGGGTGGGGCAGAAGGTCC
CTGGGCAAACAGAGAAAGACCTGGAGGAAGCACACTGGCCGGTCTCTGCACAGTCGTCCCCTGCAGGCTG
GACCTTGATTGGCCTGTGTCTTTGTAATCTGTCTTCTGGAGTATACACACACCCACCTGGCTAATAGGGC
CCCATGAGAGTGCAGAAGCTGAATGGGCCCCCTATGGCTGGAGAGTAGCAGCTATCCTTGTTGTGAGTTT
TGTTCCTGGGGCTCTATGAACAGGAGTGAAACCTCCTGCTGGGTCTTAGAGACCTCAGTGTCCTCTTCTC
CATGTTCCACTCTCATTTGTGCAGTATAGACAGTCACCCACAGCTTCTTCCATCACTCTTGCCCACCCAA
GCAGACAACTCCTTCAGGCATATCCTGGTAGCATGGTAGGGCGAGAGCTGCCTTCTCATCCCAGGAAGAG
GTCAGGGAAAATCTGGGGACAGGGATGGGAACAGGGTGGCAAAGTGAGAAGGCAAAGGGAAATTGGGGGT
GGTAATGGACAGCAAGGAGAAGTCATGCTCAAAATGGCTGGGTTTAGCCAACAAAAGGGGATGGCGGCCC
AAGAGGCTGAAGAGAAGGCCAGTGTTTATTAAGACAGGTGGTCAGAGACATCTAAGAAGAAGAGCGACAG
CCAGAGGTCAGATCCTAGGTAGGAAGTCTTGGAAATGGTGCCCTTGGAAAGGAGACCACAGAACATTCTT
TAATTTGAGGTAGCACACACACATCAGGGAAATTCCCATCATGCCATCCCACAGAGACAGAATTGCAGAT
GCTATTACTACGACCCCCGCCCGGAAAGTGCAAGGAACAAAGTTTACCCAATCAGCTGCCAGGCTGATAA
TGATGATCATTACAACTTCCATGAGGGTAGCATTTAATCAGCTTTTGGGAACACTTTCAGGGTTGGGTTT
TTTTGGTTGTTGTTATTGGTTTTATTTTTTTTTTCTTTTGGTTTTTCTTTTCTTTTTTTTTAATCTCAAG
TCACTCCCTCTAAAAGATAGTGGAAATAAATTTGAATAAACAAAACAGGTTTGCTGAAAATAAAACCAGG
ACACCTCAGCTGCTCCAGTCAGCCTCTCTCAGAAGGCCTGTCAGGCAGGGGTAGTACCTGTGACTGGTGA
GCAGTGTCCGGCATGTACCAGGTGAGTGGCCCTGATGTCTGACAGAGGAATGGCTGAGAGAGAAAGGAGT
AGAGATGGTATTGAGTGTGTAGGAAGGCTAGGCTTCCAGGCTTCCAGGCTTCTGGTCTCAGGGAGCTGCA
GGAGGTAGGGGGTGGGGCTTGTATAGTATGGGGGAACTGCAAGTGACCTGCGAGTAGCTTTCTCATTGGC
TTTTGCTCATAGGCTGTTGCATTCTTGGCAATGATCGTGGGAACCCACACCGTCAGCTTGCGGATCCAGG
AGGGCTGCAGTCACTTGCCCAGCTGCTGCCCCAGCAAAGAGCAAGAACCCCCGGAGGAGTGGCTGAAGTG
GAGCTCTGCATCTGTGTCCCCCCCAGAGCCTCTGAGCCACACCCACCACGCAGAATCCTGCAGGGCCAGC
AAGGATGGCCCCCTCAACAGCAGGGCCATCTCTCCTTGGAGCTATGAGTGAGTGTCCGTAGTCCCCTCCT
CAATGTTCTCATGGATCCCCCAGGGCATGGATGAGGGGCCGGGGGAGTTCCACCCAATTTGACCTATTTT
AATTAATTAAACAGACCAGATAGGTTTGGGAGCTACACAGGCCTGAATTTGACTCTCAGCTCTGTCCTCA
TTGTGTTGGGTGATGTTTTCAAAGTTCCTTCCTTCCTTCTTTCCTCTAGATTATATTCTAGAGGCTAATA
CATAGGTCAAATGCAACAATGTATGTAAAGCCTGTATTTATATTGATTCTGTTTCTTGTTTAGTCTCCAC
CATAACTCATATGTCTCTAAAGTATCAGGTGACATAGACACAAAGCACCACTATGCCAAATGCTGTCACT
CGACCCTGGTGGGGCAGGTGGGAGGCCAGATCCCTAGGTTTCTCATCTTTAATTAAAACCCCAGCTCTCT
TAATCTTTTACACAGCGTGTCACATACACATTGTAACTCTTTATTTATGACATGATATGAAACTGGGACA
GAGAAACCATTTACAAATTAGGGTCTTAGGGATTCCAAACATGTGATTTCATTCCTGTATACTCACATGG
TTATACAGCCCCCCCCCCGTGTGTCTCAGTTTCTTAGCCTTATCTTTGAGGGGTTATGAAGGGATTCCTG
GTATAGGGAGCTGGTCAGCTTTAACTGATATTGTGTCTAAGACACCAGTTCATAATGCCTTGGAGTTGTC
TCAGAGGCTACGTGGAAGATCTGCTTGGGGAGTGGGGGTCTCAGCTACACCTGTCCACTTTTTGGAAAGG
CAGTAATAACCCTTGATGACCACTTAGCAGACCCTTTGACATATGCTCTCACAACACTGGTCCCACACGC
TGTTTCTCAGGAAAAAAAAAAGTAATGGTGTCAAGTTAAATTTGTGAAAGGTTACAGAGCCCCATCCCTT
GAAGATTCATTGCTCTCCATACATTACAATTGGCAAGAAGTCTACAAAAAGAAGCCGTTAGTGTCCCCCA
AACTTGTTAGATCGCAGAAGCTTTTGTTTTACAGACAGACAGGCAGACAAATAACAAAAACAAAACCTCA
AGGTATTTATTATGGACGCTTGCGGCAGTTGGACCCCAATTTCCCAGGGCTCATATGGGAAATGGTTCTA
CCACACTGGGGCTTCCCGCTAGGCTACTGGATGCAATATATATATTTCTTTCCAGTTTTTGTTTTGATCT
GGGCTTTGTTGTTGTTGCCACAAATCTTTTCTGAATTGGTAAGAAAAAAAAGTCTTTCCCATGACCTAAA
TGTGCCTGTAATCCACTCTTGGGCTGTGACTGGAGAGTGGACATGAAGCAGCTCTCCCTGGGGAGTACAT
AGAACAAAAGGAAACACTTGTTCTCTGTGTATTCTTTTATATGTGCCTGTCGACTGTGTGGCACAGGTTA
GCCTCAAACTTATGGCTGTCTTTGCCTCGGCCTCTCAAGTGCTAGGGTTACAGGCACGTGCCACCTCACA
GCAGTTTTTAATTTTGTAATAGCTGTAATTTAGATAAACATCATAAAACGGAATACCTTCCTAAGAAGCC
TCATGCATATCAGACCGGTCTGCATTGGTCTGGTGGAGGCTGGCAGGACAGTCTTCGCCTTCCCCTGTGC
TGTAAGAAGCTGTCATGTCTATGGCCTGGCATTGAGAGCCACTAGGAAAGCCACGTTTTTGTTGCCTACC
TAAATTAATAGTGGGAGGAAATATTTCTCAGAGAGAAAGGGGTAGCAAAGTTACACAGTATTGGGTGCCA
GAACAGATTTAAGAAGTTGAGTCCCCCAACCACGCCATTTGCTCCCTCCAGCGTCTCTACCCCACCTGCC
CCTTGCTTCTGGCCTAATCAGCTCTGTCCCCACAGGTTGGACAGGGACTTGAATCGGGTCCCCCAGGACC
TGTACCACGCTCGATGCCTGTGCCCACACTGCGTCAGCCTACAGACAGGCTCCCACATGGACCCGCTGGG
CAACTCCGTCCCACTTTACCACAACCAGACGGTCTTCTACCGGCGGCCATGCCATGGCGAGGAAGGTACC
CATCGCCGCTACTGCTTGGAGCGCAGGCTCTACCGAGTCTCCTTGGCTTGTGTGTGTGTGCGGCCCCGGG
TCATGGCTTAGTCATGCTCACCACCTGCCTGAGGCTGATGCCCGGTTGGGAGAGAGGGCCAGGTGTACAA
TCACCTTGCCAATGCGGGCCGGGTTCAAGCCCTCCAAAGCCCTACCTGAAGCAGCAGGCTCCCGGGACAA
GATGGAGGACTTGGGGAGAAACTCTGACTTTTGCACTTTTTGGAAGCACTTTTGGGAAGGAGCAGGTTCC
GCTTGTGCTGCTAGAGGATGCTGTTGTGGCATTTCTACTCAGGAACGGACTCCAAAGGCCTGCTGACCCT
GGAAGCCATACTCCTGGCTCCTTTCCCCTGAATCCCCCAACTCCTGGCACAGGCACTTTCTCCACCTCTC
CCCCTTTGCCTTTTGTTGTGTTTGTTTGTGCATGCCAACTCTGCGTGCAGCCAGGTGTAATTGCCTTGAA
GGATGGTTCTGAGGTGAAAGCTGTTATCGAAAGTGAAGAGATTTATCCAAATAAACATCTGTGTTTAAAG
TG
Protein Information
Protein Name transcript variant X1
NCBI Protein GI 18141561
Protein Accession NP_542767
Protein pI 7.9
Protein Weight 18018.88
Protein Length 169
Protein Sequence 
>NP_542767.1 interleukin-25 [Mus musculus]
MYQAVAFLAMIVGTHTVSLRIQEGCSHLPSCCPSKEQEPPEEWLKWSSASVSPPEPLSHTHHAESCRASK
DGPLNSRAISPWSYELDRDLNRVPQDLYHARCLCPHCVSLQTGSHMDPLGNSVPLYHNQTVFYRRPCHGE
EGTHRRYCLERRLYRVSLACVCVRPRVMA
Epitope Information
IEDB Linear Epitope