VIOLIN: Vaccine Investigation and Online Information Network

MUC1

General Information

Protegen ID

703

Sequence Strain (Species/Organism)

Homo sapiens

Taxonomy ID

9606

Molecule Role

Protective antigen

Molecule Role Annotation

Vaccination of wild-type mice with MUC1 RNA-transfected DC induced anti-MUC1 immune responses against MUC1-positive MC38/MUC1, but not MUC1-negative, tumor cells. Mice immunized with the transfected DC were protected against challenge with MC38/MUC1 tumor cells. Furthermore, mice with established MC38/MUC1 tumors were eliminated after receiving the vaccination (Koido et al., 2000).

Related Vaccines(s)

Ad-sig-hMUC-1/ecdCD40L Vaccine , adenovirus-transfected autologous DC vaccine plus CIK cells , Anti-idiotype MUC-1 Monoclonal Antibody Vaccine , Autologous Dendritic Cell-Tumor Fusion Vaccine , Emepepimut-S Vaccine , Falimarev Vaccine , Fowlpox Virus Vaccine Vector , Globo H-GM2-Lewis-y-MUC1-32-mer-TF(c)-Tn(c)-KLH Conjugate Vaccine , Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH Conjugate Vaccine , Inalimarev Vaccine , Liposomal MUC1/PET-lipid A Vaccine , Lung metastasis DNA vaccine pCEP4-MUC1 encoding MUC1 , Mammaglobin-A DNA Vaccine , MUC-1 Peptide Vaccine , MUC1 Antigen/SB AS-2 Vaccine , MUC1 Peptide-Poly-ICLC Vaccine , MUC1-KLH Conjugate Vaccine , MUC1-KLH Vaccine/QS21 , MUC1-targeted Peptide GO-203-2C Vaccine , MVA-MUC1-IL2 Vaccine , PSA:154-163 Peptide Vaccine , Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine , Recombinant Vaccinia DF3/MUC1 Vaccine , Recombinant Vaccinia-MUC-1 Vaccine , Recombinant Vaccinia-MUC1-B7 Vaccine , rF-MUC1(DF3)/TRICOM Vaccine , Synthetic MUC1 Peptide Vaccine

References

Koido et al., 2000: Koido S, Kashiwaba M, Chen D, Gendler S, Kufe D, Gong J. Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA. Journal of immunology (Baltimore, Md. : 1950). 2000; 165(10); 5713-5719. [PubMed: 11067929].

Gene Information

Gene Name

MUC1

NCBI Gene ID

4582

Genbank Accession

AC234582

Chromosome No

Locus Tag

RP11-263K19.2

Gene Starting Position

155185823

Gene Ending Position

155192914

DNA Sequence

>NC_000001.11:155185823-155192914 Homo sapiens chromosome 1, GRCh38.p12 Primary Assembly
GTTGGCGCAGTGGGAGACCACGTTTTATTCAGTCCAGTTCAGGATCCCCGCTATCTCAGGGCTCTCTGGG
CCAGTCCTCCTGGGAGCCCCCACCACAACACTTCCCAGGCATGAGCCCTCAGGGGCCCACATGAGCTTCC
ACACACTGAGAAGTGTCCGAGAAATTGGTGGGGCCTCTGAAGGAGGCTGTGAGCAGCCCACCTGAACTCC
CAGCTCACCAGCCCAAACAGGGTGCAGGGGCTCTGGCCCTGAAGAACCTGAGTGGAGTGGAATGGCACTG
GCTGGCCACTCAGCTCAGCGGGCGACGTGCCCCTACAAGTTGGCAGAAGTGGCTGCCACTGCTGGGTTTG
TGTAAGAGAGGCTGCTGCCACCATTACCTGCAGAAACCTGGGTGGAAGGAAAAGAGATCCAGGGTGAGGA
GCAAAAGGTACCTCCTAGAGCCCCTGGATGCCACCCCAGGCTGGGGTAATCAGTCCAGAGTCCTGGCCAG
CTCTCAAAGGGTTAATTCAGAGAGAGCACCTGCCACCCCACCAGCCAGGTGACTGTAAACAGGGCTGCCC
TCCTCCCTCTGCTCTCCTTCACTCCCTCTTCTTGGCTCTAATCAGCCCCCTTGTCCCTCCATTCTCTGCT
GTTCCAGCCTAAGGAGGTGTGTGTGTGTGTGTGTGTGTGTTTTGGGGGGCGGGGTGTATCTGTGTCTTTG
TAAAGCCGAGAGAGGGAGGTCTCCAGGAGGAGGAAAATAGGAGCAAGAAAACTAAACTCTCTCCTCCCCC
ACCTGGAGTGGTTTTCCAGCCTCAGGTGGCTGCAGTAATTATTTACTAGGTCCCATAGAGAAAGACCAGG
AGAGGAAGGAGGGAGCGTTCCTTGCTTCCTTGAAGCTCCCAAGAACCCCACTGGCACCCACGCTCACCTG
GTCTGCTGACACTTCTTCTTCTACCTGGGAAACCTCCCCCTATGCCAGCCTTTCTCGGTCTACCCTCCAT
TCCTAGGAGATGATTAGGGGCACAGAGGCTCACCCCTGGGACTCCTCGGGAAGGGCTCCCCTGGGCATAG
TGCTCCACCCATTTTGCCTCTGGGTGCAAAAAAGCAAAACAAAACAAAACTGCCACGGTGGCACCAGTTC
AGCCAGCGCCAGCCAGCATGAATGTGGACGGCCAATGATCTTTTAGGAATTCTGGCAGTGGGGCCACTCC
CTCTTGAGGGCCCCTTTCTTCCATAGTCTCCTCCCAGGCCTGTCCCCCAAAACTCCTCTGACCTCTGCCC
CTCATCCTTGCCAGGCCCTCCCCTGCTCACTTCACGCCACTTCTCACCTCTTCCAAGCTCTTTGGGTTTT
CCAAGTACCCCCTTCAGAATCCTTGCCCAGCCAAACCCTCTGCTTCCCCTGGCCTGTGGGGCCCAATCTC
ACCTTCTCATAGGGGCTACGATCGGTACTGCTAGGGGGCACATAGCGCCCATGGGTGTGGTAGGTGGGGT
ACTCGCTCATAGGATGGTAGGTATCCCGGGCTGGAAAGATGTCCAGCTGCCCGTAGTTCTTTCGGCGGCA
CTGACAGACAGCCTGGGGAGATAGGAGGTTATGGCAGGCCATGGAGTGCCTTCTACCGGGGGGCTCTGAT
CAGGGCCAGGGACTGCACTCACCAAGGCAATGAGATAGACAATGGCCAGCGCAACCAGAACACAGACCAG
CACCAGCAGCGCGATGCCCCAGCCTGGCACCCCAGCCCCAGACTGGGCAGAGAAAGGAAATGGCACATCA
CTCACTAAAAGGAAAAGCAGTGGTCAGGGCAGTCTCCCAGAGGAGGCGCCCCTCCCGCTGCCAGCACTAA
GGAAAGAGCGGGGACCCAGACACTGGAAGGAGAGGGGCCCCGGCATGGTGCTGGGCTGCAGCCAGGGAAG
TAGCCTCACCGCTGACGTCTGAGATCGTCAGGTTATATCGAGAGGCTGCTTCCGTTTTATACTGATTGAA
CTGTGTCTCCACGTCGTGGACATTGATGGTACCTTCTCGGAAGGCCAGAGTCAATTGTACCACCACAGAT
CCTGGCCTGGTCACAGGGAAATGGGCACTTCAGCCACGGGTCCCAGCTCTGGCTCAGCACTCTTCCCCCA
ACCTTAAGTGCACCAGTCCCTCCCTACGGTCATGACCACCACCCACCCTCCAACCACCACACTGGGTCCA
CACCCAGAACTGTACCTGAACTTAATATTGGAGAGGCCCAGAAAACCCCCTTGTTTATAAATCTGCAAAA
ACTGGGGTGAGAGGGAAAGGACTCAGGCTTGATGCAAAGGGTGTGGACAGTTCTGATGGCTGCTTCAGGG
GAGCATGGGGAAGGAAAGGCCGATACTCACCATTTCAGAAATGTCTCTCTGCAGCTCTTGGTAGTAGTCG
GTGCTGGGATCTTCCAGAGAGGAATTAAACTGGAGGTTTGAAATGTGAAAAGACAGGAAAAAGAAAGAGA
CCCCAGTAGACAACTGGGGAGAAGTGCTGTGATTGGAGGAGGTGAGAGGAGGTACCGTGCTATGGTGAGT
GCTACTGGCATCAGTCTTGGTGCTATGGCTGGCAAGGGTGGTAGGAGTATCAGAGTGGTGGCTGGGAATT
GAGAATGGAGTGCTCTTGCTGGCTGGGGTTGTGGTAGCCCTGGCAGAGGTGCCGTTGTGCACCAGAGTAG
AAGCTGAGCCTGATGCAGAGCCTGAGGCCGAGGTGACATTGTGGACTGGAGGGGCGGTGGAGCCCAAGGC
GGGCCTGTTGTCCGGGGCCGAGGTGACACCATGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTG
TCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGGGTGGAGCCCGGGGCCC
GCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGTGCGGTGGAGCCCGGGGCCGGCCTGGTGTC
CGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAG
GTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGTGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGT
GGACTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGG
GGCGGTGGAGCCCGGGGGCCGGCCTGGTGTCCGGTGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGA
GCCCGGAGCCGGTCTGTTGTCCGGGGCCGAGGTGACACCGTGTGCTGGAGTGTCGGTGGAGCCCGAGGCC
GGCCTGGTGTCCGGGGCCGAGGTGACACTGTGAGCTGGGCTGCGGGCGCGGTGGAGCCCGGGGCCGGCCT
GCTCTCTGTTTTAAATATACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGACGGCCTGGTGTCCGGGG
CCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGAC
ACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCT
GGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGG
TGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGG
GGCCGGCCTGCTCTCCGGGGCCGAGGTGACACCGTGGGCTGCTCTCGCGGTGGAGCCCGGGGCCGGCCTG
CTCTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGG
CCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGAC
ACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCT
TGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGG
TGTAGCCCGGGGCGGGCCTTGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGG
GGCGGGACTGGTGTCCGGGGCCGAGGTGACACCGTGGGTTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTG
GTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGCTCTCCGGGG
CCGAGGTGACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGCCGGCCTGCTCTCCGGGGCCGAGGTGAC
ACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCT
GGGGGCGCGGTGGAGCCCGGGCCAGAACTGCTTTCCGGGGCCGTGGTGACTCCGTGGGCTGCGGGCGCGG
TGGAGCCCGGGGCCGGCCTGCTCTCTGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGTGGAGCCCGG
GGCGGAACTCTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGGGGGGGAGCCCGGGGCCGGCCTGGTG
TCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCTGGGGCCGGCCTGGTGTCCGGGGCC
GAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACAC
CGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGC
GGGCGCGGTGGAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTG
GAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGG
CCGGCCTGGTGTCCGGGGTCGAGGTGACACCGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGT
GTCTGGGGGGGCGGTGGAGCCGGGGCCGGCCTGGTGTCCGGGGTTGGAAAACTGGGCTGGGGGGGCGGTG
GAGCCCGGGGCCGGCAGGGGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGC
CGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTG
TCCGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGCGGGCCTGGTGTCCGGGGCCG
AGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACC
GTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTTGG
GGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGTGG
AGCCCGGGTCCGTCCTTCTCTCCGAGGGCCGAGGTGACATCGTAGACTGCGGGCGCGGTGGAGCCCGGGT
CCGGCCTGCTCTCCGAGGCCGAGGTGACACCGTAGACTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGT
GTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGAACCGGCCTGGTGTCCGGGGCC
GAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACAC
CGTGGGCTTGGGGGGCGGTGGAGCCCGGGACCGACCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGC
GGGCGCGGTGGAGCCCGGGGCGGACCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTG
GAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGG
CCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGT
GTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCTGGCTTGTTGTCCGGGGCT
GAGGTGACATCGTGGGCTGGCGGGGTGGTGGAGCCCAGGGCTGGCCTGGTGACTGGGACCGAGGTGACAT
CCTGTCCCCAGGTGGCAGCTGAACCTGAAGCTGGTTCCGTGGCCGGGGCCAGAGTGACATCCTGTCCCTG
AGTGGTGGAGGAGCCTGAACCGGGGCTGTGGCTGGAGAGTACGCTGCTGGTCATACTCACAGCATTCTTC
TCAGTAGAGCTGGGCACTGAACTTCTCTGGGTAGCCGAAGTCTCCTTTTCTCCACCTGGGGTAGAGCTTG
CATGACCAGAACCCGTAACAACTGTTGCGGGTTTAGGGGCTGTGGTAGCTGTAAGAAGTTAAAGTCATAG
GGTTGGGTCTTTATGAAGGAAAAATAAGAGCAAGAAGAAAATATAAGCTCTGGCCACCAGAGAAATAATA
CCAGGAGGACTGGGGAGTGGGCAGCCTCAGTAACCCCTGGGTTGGCCGCCTCCTTCCCTGCAGCAGCCTC
CTTCTCTCTGCCCATAGGCCTTGGCTCATGGCCCCTGCATTTCTTCCCCTCTTAAGCCTTCCCTCTCCCT
ACTCTCTTCCCCCTAGACTTCTCTACAGGACATTTGCTTGCCCCTGGTACCCACTCTCAGGGTTGGGGGC
AACTCTTCTCAGCCTGTCCTTAGCCTCTCCCTCCTTCTGGCACAGACAGGGCAGCCTCTGTCTGCAATTC
TTACCTTAACTTCATGGTGCCATCTGCCAGGGAGCAAAACCCACAGAAAGACCACGAAGACCACCTAAGC
AGGGCAGCCCACTCCCCACCTCGTGCCCCTCACCTGTAAGCACTGTGAGGAGCAGCAGCAGGAAGAAAGG
AGACTGGGTGCCCGGTGTCATGGTGGTGGTGAAATGGGTGGGGAGGGGGCAGAACAGATTCAGGCAGGCG
CTGGCTGCTTGAGAGGTGGAGC

Protein Information

Protein Name

transcript variant 14

NCBI Protein GI

67189007

Protein Accession

NP_001018016

Protein pI

6.67

Protein Weight

26222.24

Protein Length

264

Protein Sequence

>NP_001018016.1 mucin-1 isoform 2 precursor [Homo sapiens]
MTPGTQSPFFLLLLLTVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAFNSSLEDP
STDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASR
YNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARD
TYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL

Epitope Information

IEDB Linear Epitope