VIOLIN: Vaccine Investigation and Online Information Network

TERT

General Information

Protegen ID

705

Sequence Strain (Species/Organism)

Homo sapiens

Taxonomy ID

9606

Molecule Role

Protective antigen

Molecule Role Annotation

Telomerase is expressed in 85-90% of pancreas cancer, and immunogenic telomerase peptides have been characterised. A phase I/II study was conducted to investigate the safety, tolerability, and immunogenecity of telomerase peptide vaccination. Forty-eight patients with non-resectable pancreatic cancer received intradermal injections of the telomerase peptide GV1001 at three dose levels, in combination with granulocyte-macrophage colony-stimulating factor. Monthly booster vaccinations were offered as follow-up treatment. Immune responses were measured as delayed-type hypersensitivity skin reaction and in vitro T-cell proliferation. GV1001 was well tolerated. Immune responses were observed in 24 of 38 evaluable patients, with the highest ratio (75%) in the intermediate dose group. Twenty-seven evaluable patients completed the study. Median survival for the intermediate dose-group was 8.6 months, significantly longer for the low- (P = 0.006) and high-dose groups (P = 0.05). One-year survival for the evaluable patients in the intermediate dose group was 25% (Bernhardt et al., 2006).

Related Vaccines(s)

Autologous Renal Cell Carcinoma Tumor Lysate-Pulsed Dendritic Cell Vaccine , Cancer Subunit GV1001 Protein Vaccine , hTERT I540/R572Y/D988Y Multipeptide Vaccine , hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine , hTERT Multipeptide/Montanide ISA-51 VG/Imiquimod Vaccine GX 301 , hTERT Vaccine V934/V935 , hTERT-LAMP mRNA-loaded Autologous Dendritic Cell Vaccine GRNVAC1 , hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine , Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine , Primary Prostate Cancer Tissue/hTERT/Survivin mRNA-loaded Autologous Dendritic Cell Vaccine , Recombinant Vaccinia-CEA(6D)-TRICOM Vaccine , Survivin Sur1M2 Peptide Vaccine , Synthetic hTERT DNA Vaccine INO-1400 , Telomerase-specific Type 5 Adenovirus OBP-301 Vaccine , Telomerase: 540-548 Peptide Vaccine , UV1 Telomerase Peptide Vaccine

References

Bernhardt et al., 2006: Bernhardt SL, Gjertsen MK, Trachsel S, MÃ¸ller M, Eriksen JA, Meo M, Buanes T, Gaudernack G. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. British journal of cancer. 2006; 95(11); 1474-1482. [PubMed: 17060934].

Gene Information

Gene Name

TERT

NCBI Gene ID

7015

Genbank Accession

AB016767

Chromosome No

Gene Starting Position

1253166

Gene Ending Position

1295046

DNA Sequence

>NC_000005.10:1253166-1295046 Homo sapiens chromosome 5, GRCh38.p12 Primary Assembly
ATTTTTTTCAAAACTGAAAAACTCATATATTCAGTATTTTACTCCCACAGCACCTCCCCCCAATTTGACC
CACAGGGACCCCCATCCAGGTGCAGGGTCCTCGCCTGTGTACAGGGCACACCTTTGGTCACTCCAAATTC
CCAGAGCTCCCAGGGTCCTTCTCAGGGTCTCCACCTGGATGGTGGGGGTGGAAGGCAAAGGAGGGCAGGG
CGAGGGGTGAACAATGGCGAATCTGGGGATGGACTATTCCTATGTGGGGAGTGGAAGCCGGGCTCCTGGT
GAGGAAAAGCTGGCCCTGGGGTGGAGCCGAGCGCCAGCCTGTGGGGAAGTGAAGACGGCAGGTGTGCTGG
ACACTCAGCCCTTGGCTGGACACTCGCTCAGGCCTCAGCCGGACACTCAGCCTTCAGCCGGACATGCAGG
CCTCGGCCAAACACTCACTCAGGCCTCAGACTCCCAGCGGTGCGGGCCTGGGTGTGGGCCGCCCCTCCCT
CCCTGGGACGTAGAGCCCGGCGTGACAGGGCTGCTGGTGTCTGCTCTCGGCCTGGCTGTGGGCGGGTGGC
CATCAGTCCAGGATGGTCTTGAAGTCTGAGGGCAGTGCCGGGTTGGCTGCGGCCTCCAGGGCAGTCAGCG
TCGTCCCCGGGAGCTTCCGACTCAGCTGCGTCTGGGCTGCGGGGCCAAAATCAGACTCCGTTCCAGAAGA
GGCCAGAGGTGGCATCCTCCAACCCTCCTAGGACGTGTGGGTGGCCGGGCAGGCAGGGCCTGCACCTCGT
GGCCCTGGCTGGTGGGAACCTCAGTGAAGGGACAGACACCCCTCCACCGGGGCGAGCAGACAGGCAGCCC
AGTGACGCTGGAGCGGCGGGGCGGGGAGAGAACTTGCTCAGGACCCCAGGAGCTCAGGGCAGCAGCCAGG
GAAGAGGCTGTGAGAGGACACAGGTCAGGGGTCAGAAGGCTCCCAAGCGTGGGGAGCCATCGCCCCTGAG
ATGGGAAGCAGGGGTTCAAGAAGTTGTGGACCCTGCCAGGCTCCGTGGCCTGGGGACACCAGCGTTTAAT
CACATAGGGCTGCCAGCGTGGCTCCAGGCCCCCAGGGTCAGGCCCGGGGGCGTCTGCACTTCAGCAGCAT
CTGAGGCTGCTCGCCCCACACAGGGCGTTCAAGGATGACCCCTGGGCAGGTGGGGCCCGCACTGGCCTCC
ACCCACACTTGCCTGTCCTGAGTGACCCCAGGAGTGGCACGTAGGTGACACGGTGTCGAGTCAGCTTGAG
CAGGAATGCTTGGTGGCACAGCCACTGCACGGCCTCGGAGGGCAGAGGGCCGGCGGCGCCCTTGGCCCCC
AGCGACATCCCTGGGGGAAAACAGAGGCTGAGGAGTCACAGGCCCAGCCCAGCTCCCCTCCCAGGAGACA
CCGGAAAGCTGCCCACACCCGACGGTCTGCGGGGTGGCTCCATCTCTGGCTGTCCCGACCCAAGCACCGC
AGGAGTCACGACAGAAATGTTTTCTTCGGCTTCTCCAGGTGAAATTTCCACAACACAGAAAGAACAGAAA
GTAGAAGCTGTTAAGCTCAGGACCGCAGGTTCGACATGGCTTGAATTTCAGACGGATCAGAAACCTCCCT
GATGCTGGACAAAGTGTCCAGGGGCAGAGGACGGTGACTGGGAAGCAGAGGACGGCGCGGGGCTCTGTCG
TGGTGATACGCGGCCTCTGCTCCTGAGAGGGGTGGGGTAGCCTGGGCCTGGCCTCCTCCTAAGCCCTTGG
CCTGGGTTTGCACAAGGGCCCTAAGTGCCATGGACGGGAGACAGCCCAATCCCACCACAGGGCAAACAGG
AGAGGCCAGGCCCCCCAAATCCCACCATGGGGCAAACAGGAGAGACCAGGCCCCCCAGCGCTTCCCCAGG
CAGAGCAAGGTGGGAAGGATGGCAGCTCCCAGACAGCTCCTGTCCCTTCCATCAGGTGCTCTGCTCACCC
CACGAGAGGGCGGGCAGACGAGCCTGACAGTGGTTGGGTTAAACCACTTCCTGATGCGAAAAGGGGTAAG
AACTTCCTAAGCCCAGATTCACTCAGTCTCCTGACACACTAACACCAGCAGGCAGGCACTGCTGCCACTG
AGGCCAGGCACCTGCACATACCTGCGTTCTTGGCTTTCAGGATGGAGTAGCAGAGGGAGGCCGTGTCAGA
GATGACGCGCAGGAAAAATGTGGGGTTCTTCCAAACTTGCTGATGAAATGGGAGCTGCAGCACACATGCG
TGAAACCTGAGAGGATGGCGGACAGCGTCAGAGGAAAGGCCTCCTAATCAGACGGTGCTCGTGGGTGTGG
GCATGGGCCCACCGGTGCCTGTGTGCGTGCATGAATGCACATGCATGGGTTTCCTCATGGGCACAGGTGC
ACACACACGGATGCATGCATGCATGTCTGTGTGTGTGCTTGTGTGTGCGAGTAGCTGCGTGTCTGTGTGT
GCACAGGTACACTGCGTTTCTGTGCACCATCTGTATGAACACGCATGTGGAGGCTGAAGCAGCTCCATCC
TGGATGCCAGCCCCCCATGCTGGCTTCTGATTAGCCCCTGTTCCGGGAAGGCCTCTAAGGTTTCCAGTTT
ATCCATTGTTCCTTGTGTACCAGCAGGTACTTATCATGAATCCTGCCCTTCGTCAGACAACCTTGATGTC
ATCGTATATCAACGTCCTGCGCATCCCTTCTGAGCCACCCGCCCCTGTGGTGCATAAACCCTGGGTCTGG
GGTGATGGTGTGAGGACCCATCATCTCATCTCACTGACACCGAGACACCGACTTGGCTTCTGTGTGTAGG
TTAAGTTCCTACTAAATGTTTCTTTCCAAGAAACTGCATTTGTCAGTCTTCTTTGTTGTTGTTGAGATGG
GCTCTCACTCTGTCACCCAGGCTGCAGTACAGTGGTGCAATCTCAGCTCACTGCAGCTTCCACCTCCTGG
GCTCAAGTGATCCTCCCACTTCAGCCTCCCAAGTATTGGAACTACAGGCGCACACCACCATGCTCAGCTA
ATTTTTGTTTTTATTTTTCATAGAGATGGGGTTCTACTATGTTGCTCAGGCTGGTCTTAAACTCCTGGGC
TCAAGGGATCCTCTCGCCTCGGCCTCCCAAAGTGCTGGGACTACAGGTGTGAGCCACCGCGCCAGCCCTG
TCAGCCTCCATCTTTGGCCTCTCAGCTTCCTGGGACTTTGGGGCAGGTGTGCACAGACCTGGCTACCATG
AAACAGCACATGTGCACATGTGCTCATATGTGCGTGTGATCAGAGCCCCCGTGTACCTGGTCTGACCCTC
TGCCTGAGCCCCCCGTGTACCTCATCTCACCCAGTGCCTGAGCCCCCCATGTACCTGGCCTCACCCACTG
CCTGAGCCCCCCGTGTACCTCATCTCACCCACTGCCTGAGCCCCCCATGTACCTGGTCTCACTGACTTCC
TGAGCCACTTCTGGAATGACCTGAGATCACACCAGTCAAGCCAGCACCCCGGTTTCAGCCTCTCAGTAAC
TCTGCTGAGGTGGGATGTCTTTTCCCCATTTAGCAACAACGGAAGCCAGGCCCAGAATGTTTTTAAACAA
ATAAATAAGCCTAAGGTCCCGGGGTTGCCACACGGCCACGCTCCTGACCCAGGAGGGAAACACCTAGCAT
GGGTGAGGGGCTCTCTTCCAAAGGGAGAAATAGCCACCTGCTAGAGGTCGGGGCGTCCACCCCAAGCCCG
TGTGGAGGCGCGGCCAGCACGGGCCAGGAAGGCCGAGCCCCAGCGGATTTGAATCAGACCCCGCCCCCAG
CGCCACGTGGACCACCACAGCCTCGCCCACTGCAGCCTGGCTGCCGTGAAATCGGGGCCCAGCTCTCCGT
TCTCCCACTCCTGCCTCGAGGGAAGGGGATTCCTGGGCCTTCCACGTGCCTGACTCTGTGTTTGGAAACG
GCCCGTGGCCCATCGCATCTCGGCCTCCTCAGGGCTACCCAATCAAGCGACTACCCAAGGGTCCCCACAT
GGGTGGGGAAACTCAGCCGCCCTGCCCTGAGCCCAGGCCCTCTACGGGAGCTCCTCGGAGCTAGAGACCC
TGGTGGGGAAATGAGGACAAGACTGAGCTGAATATGGGAGGAGCAGGTGGCAGGTCACATGGCCCTGGGA
GTTTCCCAGGAGTTTTCACCTGGGAAAACTCCTCTGACCTCATCATGGCCCAAGGAGGCCCCAAGCACGC
CAGCTGGACCCTGGGGTCAACCACAGTGTCAGACACCTCCAGTCCTCAGTGGCACCTGTATCCAGCACAC
CCCAAGGGTTTCCGGAAAGGAGTCAAGCAGCTTGCACGAGGGCCCAGGCACGCGTCAGGGAGATGCAAAC
GAGGGAAGATTTGAGGCAGAGAGAGAAGGCAGAGAGGAGGGCGGTCTGAGCCGGACGCACCCTGGAACTG
AGACAGCCTGGTCCCAAGCCTCTGGAGCTGGTGCAAAGGCGGTAACATGCAGCTGTGGCTCTGCCCTCCC
TGCCAGAGCATGAAGGCGCAAGCACTCGGGTTAAAAACCATTTTCATGGTACGACCTTGTAATGGAAAAC
TCTCCCGTGAGCCCTTGCTGGGTTTCCACGATAGACGACGACCTCATTTCACATCAAGTGTGCACGGTAA
TTCGCGCAGCCTCGGCCCTGGGTAACACAAATGCTCACACTCCTTCTCAGCCCTCATGGGGCGAGGGCTT
CGGCCTCCTGGCATTCAGCTCCCAGTGGCTCGGGAGGCCTGTTGAGGTGGAGGCCCGGGCCTGTGGTGCC
CGACTGCCCTTTGGTACAGCCCCGAGGCTTGTGCCACCACCTGCCCTGACTCCAGGCAGAAGCTGGCCCT
GTGGCCTCCACAGATTGGCCCTTCCCTCTGTGATAAAGTTGTCGATTCTTGGCAGGGGCACCCCCTGACC
AGCCAGGACAGGGAACGTTCCAGGAGCACAGCCATGCCCAGAGCACAGGTGCTGGCCGGGCTGTGTGGGG
AGCCACAGCTCTGCTGCACCTTCCCGGGGGTGGGGCCAGCGACCCTCACCTGCACCCACCTCGGCCCTCT
TTGCTGAGACCCCAAATCCTCCGGGCATCTGATCTCCCATCTACTGTTCAGACACCTTCCCAGCCTCCTC
TGCTAAGACTCCCCATAAACATCTCTTTACCCCATGCCCCTGCTGCCCTGGGATGGCCTCCATGACGTCC
CACGGCCAGTGCACAGGCACAGTGGGGACACCTGGGGCCACACCGGCTCCTACCACTACCCAGAGATGGA
GAACAGGTGCTTTGCACAGAGCCACGCGAACAGAACTGTGCACAGGCAGCAGCACCACTGAAAACGTAAG
ACATTCCTTGCCCCTAAAACCCAGGAGTTCCAAGGTGAAGCCCCGGGTCAGAGGTGAGCAGAGCGCGGAG
GGTCCCTGGAGGCTGGGCCTGCACCCCTTGGTGGCGGCTCACCTGTACGCCTGCAGCAGGAGGATCTTGT
AGATGTTGGTGCACACCGTCTGGAGGCTGTTCACCTAGAGTCGCCAAGAAAGAGTGAGAAACGGTAGAAA
CCTCTCTGGGATTTTAAGTTTTTACTTTTTGCTTTATCATCCATTCAGATGGAACAAGAAAGAGGAACAT
TTTGACAAGAAACTATCCCTCTTCCCAGTGAAATCCGGCCTGGCCCTCACCCGGCAGCTGCGAACCACCC
TGGGCGAGTCAAGACTCTGTGTCATCTGCCTGCCCCCGAGGCTCGGCCAAGACAGGAAGGAACCAGGAGA
GGGAGTGGACGCAAATGCCCACAGAGAGGGGAGGTGGACGCAGATGCCCACAGAGAGGGGGAGTGGACGC
GGATGCCCACAGGAGAGAGGGAGTGGAGTGGATGTAAATGCCCACAGGAGAGGGGGAGTGGACACAGACG
CCCACAGGAGAGAGGGAATGGAGTGGATGTAAATGCCCACAGGAGAGGGGGAGTGGACACGGACGCCCAC
AGGAGAGAGGGAGTGGATGCAGATGCCCACAGGAGAGGGAGTGGACGCGGATGCCCACAGGAGAGGGGGA
GTGGAGTGGATGCAGATGCACACAGGAGAGGGAGTGGACGTGGATGCCCACAGGAGATGGAGTGGATGCA
GATGCCCACAGGAGAGGGAGTGGACGCGGATGCCCACAGGAGAGGGAGTGGACGCAGATGCCCACAGGAG
AGGGAGTGGACATGGACGCCCACAGGAGAGAGGGAGCAGACGCAGATGCCCACAGGAGAGGGAGTGGATG
CGGACGCCCACAGGAGGGGGGAGTGGACACGGACGCCCACAGGAGAGAGGGAGCGGACGCAGATGCCCAC
AGGAGAGGGAGTGGACGCGGACGCCCACAGGAGGGGGGAGTGGACACGGACGCCCACAGGAGAGAGGGAG
CAGACGCAGATGCCCACAGGAGAGGGAGTGGACGCAGATGCCCACAGGAGAGGGAGTGGACATGGATGCC
CACAGGAGAGGGGGAGTGGACACGGATGCCCACAGGAGAGAGGGAGTGGACGCAGATGCCCACAGGAGAG
GGGGAGTGGACACGGACGCCCACAGGAGAGACGAGTGGATGCAGATGCCCACAGAAGAGGGAGTGGACGC
GGATGCCCACAGGAGAGGGGGAGTGGACACAGACGCCCACAGGAGAGAGGGAGTGGATGCAGATGCCCAC
AGGAGAGGGAGTGGACGCGGACGCCCACAGGAGGGGGGAGTGGACACGGACAACCACAGGAGAGAGGGAG
TGGACACAGATGCCCACAGGAGAGGGAGTGGATGCGGATGCCCACAGGAGAGGGGGTGTGGACGCCCACA
GGAGAGGGGGAGTGGACACAGAAGCCCACAGGAGAGGGAGTGGACGCGGATGCCCAGATGGGACAATGCC
CTCAGGGCTGCAGCTTCAGAGCCTCAGCCCACCAAGGCCTGGGACCCCGTCTCATCCTGTAAGGAGTGGC
ACTGGTGCTGAGGACCTAGCGGGGTGAACACGAGGACCCCTCAATACATGTTATGTGCACACATGCTACT
CACACTGCACACCCACACGCATGCACCTCACGTGAATGCCCACACGACTGTGCACGAACACACATGCATG
TCAGGTGTGCATTCGCATGTGCACACACTTGTGCCCTTGCACACCTGTGCACACACTGCCATGCCTTCAT
GTACACACATGCACACATGTATGTGCTCACGTGTATATGCGTACATGTGCACTCTTACGTGCAGCCAGTC
ACCATCAGCCTTGCAGGCACGCGCGCACACACACACACACATACTTGCGCACACACCTCCTGAACTCTGA
ACTCTGTGCTGACCATCAGCCTGCTCACCTGCAAATCCAGAAACAGGCTGTGACACTTCAGCCGCAAGAC
CCCAAAGAGTTTGCGACGCATGTTCCTCCCAGCCTTGAAGCCGCGGTTGAAGGTGAGACTGGCTCTGATG
GAGGTCCGGGCATAGCTGAGACACAGGGGGGAATGTCAGACACAGGTGCCTGCCCCACACCCAGCCCCCT
CCTGCAAAGCTTGCTCCAAAGAGCCTCCTGCCTTCCTCCCGCTTCCTTGTCCTGCCTGGGGCATGCGCTG
CAGCCCGAGGGGGCTGGGTGCTCACTCCATGGACTCCAAATGCTACATGCCATCCAGACTCTGCATGACC
AAACTCCACCAGGACCTGGCTAGTGATGTTGAGTGTATCCAAACCTCGCACGGCCGTGTTTGTGCACTCA
TCATCTGCCCTGATGAGATCTGCACATAACTCAGCCAAAAACACATAATAAACTGTGGAGCCCTGGCTCC
CGGGCGTCCCTCGAGTGAACACAGGTGTGACTCAGGTTTTTTGTGGGAGAACACTGAGTTGGGCGTGGGG
AATCTCACTGTGTTTGAATCTCAGGGATGGAAGAGCCAGGTGGCACCAGCTAAACAGGGCTCCAGTGAGT
GCACGTGGCACACATGGTGTCTCCAGAGGGGCAGGATGGAGGCATCCCACCGATGTCCTCCAGGGCCTCA
CCACCACTCACTGCCCATGTATGTCCATGTCCAAAGATGAACACACATGACATCCACGGCAGGCTCCTGG
GGTGTGTTCTTTTACATCCAGCTTTGAACACTGCTACATTGAAATAAACGTTTTGTGCCATTAAACATTC
TTCAAAAATTCTTTGAAAAATGTTTAATGGCAGAGCAAGTTTTGTGATGCATAATATCTCCTTAGCCCTG
TATTTGGGCAGGTTCGTGACTTGCTGTGGCAAGTCCCCCTGCCTGGAACACTGGAAATGGTAAATAAGAC
CCGTGATAATGTCTGGTCACTTCAGAAGTGGAATTACTGGGAAGACACAGGACATTGTGAGGACTTCCAT
GCAAACAAGCTGCTTTCCAGAAAAGTCTTTCCAGCTTGCCTCAACCTGATGCTGGCTCTTGGCAAGCCCA
GAAAAGGAGCCAGCATGAGGGATGGGGACAGGTCTCGCCATCAGTTTCACGTGCGTTTCTTTGAGGGATG
GGTCTCGCTGTCAGTTTCACATGCATTTCTTTGACGCTGCTGGTAGGACCTTCCCAAGTGTGCATCAGAC
GTCCATTTCTTCTTTCACAGCCATCCCCAACACGACCTTGGGCTCCGGCTCACCCTGAGCCTATGGGTCT
GACTTGTGTGGGGTCCTCGGGCAGAGCAAGGGCCCCGGAGCAGGAGGCCAGGCTGCAATCATGCATGCCC
TTTGCCAGCTGGGTGACCAAGGGCGGCTGCTCCCCTGGAGCCTTTCCTCCTCTACCTCTCAGGTGGTTAG
GAGAACAAAGTGAGAGGATGAATGTGCAGGACCTCACAGGGCGCCTTAAATAAATCACGTGCACAAACGC
TCCAGGGAATGGCCATTTTCACTGTGGCTCAGGCAAGCTGAGTTTCTCTGCAGTGAAAGCAATGCCCGTT
GCCTCACTGGTTTCATCCGCCTCCCTGTGTGTCCTTCCCCAACACCAAACCAGGGAACGTTCACCTCCCT
TCCCTTTGAGTCTTTTGTTTTATTTCTGTTGCTGGTGTTGTTTGCATGTGTCTCCTCTTCTACCTAGAAT
CTGCTCTGGTATATGCTGTAAAGACACAACTTATTTGCTTCCAGTCAGTTTTCTCAGAAAAAAAAATTAC
ACACACACTCTCTTTTCCATCAGCTGTGCCACATACCACATTAACACACGTTTCTGAGAGATAGGGCTTC
CGTTTTGTTCTATTGTTCTGTCCATCAGTTCTGACCACATTCTACCATCTGAGCTGTGGTTTGGGAGACT
AAAATCTGGACAAGAAAATTCCCATCTTACCACTTTTCCTTTTTCACTTTTCTTAATCATTTTGCCTGTT
TTCTTCTCCCAGATGCCCTTCAAGCCTCTGCTGTATACTTCAGACACAGAGGATGTGAGTTCACCCTGAG
TATGGCGAACCACTGCCTCCACTGCTGAGCTTTTAGAGCCACCTCTGCAAGCACACACTCTGACCAAGTG
GCCTTTGGGAGCACAGAATATTCTGGCATTGGACCCACATCTGATGACCTGATGCCCACCCATCCTGCAC
TAGCCTCTGTGGCTTTGCAATGTGTTTAGAGAGAACCCATTTTCCTGATTTGTTTGTCTGTCCTTTGTCC
TTCAATAACATTCACTGATGCTGTGCCAGAGGCTGGAACCAGGGGTGCCTGTCCTAAAAAATACATTTCA
TGGGGAGCAAAATAAGCAGTGGACAGTTCACAGCTGACTGGTATGGCCAGCACTGCAGAGGTGCCTGGGA
GAGGCGAAGAGGTGCTGGGAGCCCAGGAAATGTGGAAATCATGCAGACAAAGCCAGTGGAGGCCAGGACC
AGGTAAGGCTGTGAGAGGGAAGCAGGGACTGTGGGGAGCACAGGAGACCGGCATCCTTGTGGGGAGGGAG
CTGCAACAGGGACATGCTGGGCACCATGCACAAGGGTGTCTGCACCTGCCACTCCCCCATCATGAGGGCG
TCTGCACCTGCTGCTCCCCCATCACGAGGGTGTCCACACCTGCTGCTCCCCCATGAAGCAAACCCCAGGG
AGCATTCTGGAAAGAGGCAAAGTCCAGATCTGGACTGTTAACTCAGAACGACAGGACCCCAGTTTAAACC
TCTGGTTTAACAACCATCCACCACTTATTTCTCTTCCCATGAAGGTGTGCCTTTCAGAGGAAGGCACCCC
CAGTTCCGGCCTCTAGCACAGCACCAGTAAATATTATCGAAGGACAGAATAAAAAAACACCTGTCCACTA
TGGTTTTGGAATGCTGATACTTTTTTTTTTTTTTTTAAGATGAAGTCTCACTCTGTTGCCCAGGCTGGAG
TGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAATGATTCTCCTGCCTCAGCCT
CCCGCATAGCGGGGACTACAGGCGTGTGCCACCAGGCCAGGCTAATTTTTGTATTTTTTAAGTAGAAATG
GAATTTCACTATGTTGGTTAGGTTGGCCTCAAACTCCTGGCCTCAAGTGATCCACCCACCTCGGCCTCCC
AAAGTGCTGGGATTATAGGTGTGAGCCACCTTGCCCTGCCTGGAATGTTGATACTTTTTATTCATAAAAG
AAACAGCACAGATTTCTGCATCTGTGTCCATCTTCAATTCATTTGTGTCTGAGCCTGAGACGGGGCCTTG
AGCTCTCGGGCTCTGGGGAAACAAGACCCCAGAATTTTGTAGAGACCCCCCCCACACCATGGCCCTGTCC
CCTGATGGGTCACACGTGATCATGAACTCATGGCATCCTGTAGACTGTGGATGAGCCTTGGAGTGTGGGG
CTCACAGCGGAGAGACTCACGCCCAAAAGGGCCCTGAAGTCTCTGGGTTCGGAGAGACTCACGCCCAGCA
GGGCCCCAGGGTCTCGGGTTCAGAGGGACTCATGCCCAGCAGGGCCCCTGTGTTTCGGGTTTGGAGAGAC
TCACGCCCAGCAGGGCCCGGGCGTCTTGGGTTCGGATCCAGACTGCTTTCTGAAGACACCTCAGTGCACC
CAGGTCTGGTGCACCATTTCCTTTTACCAAAATAGCACAGAAAACTGCTCCCGTTGTGAGCACCCTCACT
CCCACAGAAAGATGCATTTCTGCTCAGCCCCAGATGGGACGAGGGGCACCCTGTGGCCTCTGACCCTTTG
GGATTGGCAGTCGCCTGCCCCACACGGAAGCAGAGGTGGACGCAACGGCCCTGCAGCAGCACCTGCCCCA
GCCGGGCACAGGCTCCACTTCCGGCCAGGTGCGCTCACCTGGAGTAGTCGCTCTGCACCTCCAGGGTCCG
GGTATCCAGCAGCAGGCCGCACCAGGGGAATAGGCCGTGGGCCGGCATCTGAACAAAAGCCGTGCCACCC
AGGGCCTCGTCTTCTACAGGGAAGTTCACCACTGTCTTCCGCAAGTTCACCACGCAGCCATACTCAGGGA
CACCTCGGACCAGGGTCCTAAGGCAGAGGGGCAATGTCAGCCCCAGGATGCGGGGCCGTCACCCAGGAGG
TAACCTGACACCCTTGTTAAATGCTTTGGAAAACCCCAGAGAAGTGGTGATTTGGAGCAGGGTGCTGGGC
CTGGCAGGAGCTCTGAGGAGCCTGGACCCAGCCCTGCTCCAGACTTCGGGGTGCTTTCCCTGTCTCCCGG
GCAGGACAGGTAGGTGAGCATGCAAGAACCTGGCCTGGACCCGGGACAGCCAGGACTCAGATGGGAGGTG
CAGCCCCAGTGGCCTCTGTGATGGTCCATCTCATGTGTCCCCATGGCAACACCACAATCCCGTTATAGAC
TCATCTGTGGTCCGGGGCAGACTAAAATCTGGACAAGAAATTGCCACCATCCCACCTTCTTTTAAGACGT
TTCTCAACGACTTTGCCTGTTTTCTCCTAGATGCCCTGAAGGCATCTGCTGTGCTTTAGACAAAGGGGAG
GGTTCTGAGTTCCTGCTCAGGCGCGGGACCTGGCTGGGCTGTGAGCTGGGCAACACCAGTCGTCAGCTTC
ACGTCAAGGAGGTTCCCTCGCCGAGTCATGAGCCTCGCTCACCCAGCTCAGGGAGCCCCCCTGTGCCCGG
TAGCCTCTGCTCTGGCCTGGGCATCCCCTTCCCTTCCTGCGGCCTCTGCTGTGGCCCCGGGCGTCCCCCT
GCCCTTCCTGTGGCCTGGCCCTGGGACCTCGGCCAGCTGCGCAGCTCCCCTGGTGCATTCCCAGCTCCCT
GTGGCCACCCCTTCCTGTTACATGGCTGCCGACTCATCAGAGACAGAGTTCTGCCCCCGGTGGGACCCCA
ACATACACTCTGAGCCACCTCCCTGGCCAGCACCCTCAGGAACTTGCCACACAGAAGCAGCGTTCCCCGT
CTGCTCTGTCCCCTCAGCAGCCTCAGGACTCCTGAGCCCTCAGTTGCTTGGGACCTGGGCTCCCCCCGAG
TGAATCTTAGTGGATTTAAATGTGCACAGCCTGCTGTGCTCCGGGCTGCGGCACAAGGAACGCCAGGCAT
ACCCCCAGCCCAGGGCGGCCCTGGAGGGTGGACCTGGAGGGTGGACTTGGAGGGCGGGTCCAAATGGGTT
TTCACAAACACAGCCCAGCAAAGCACCTGAAACCACCCCTGGCGGCCACATTTTCTGAGGGTTCCCTTTA
CAGCTTTCAAGGTTTCTCGTCCCTCGTCAAATCGCACTTTAAAACAAGCCCACCGGCTCTGTGGGGCGCC
CTTGAGGGGGACCACATTGGACAATCCCCTGTGCTGAGGCCAGGTCCCCTGTGCCTGATTTTAGTTTGAT
TCACAAAAATCAACTCTGAAACCCACTCCTAGCCATCTCCGTGGTTCAAGACAGCAGCACTCAGCAAATC
CAAATTCTCCCACCGATCCCAAACAACCCCACGCAGGAACGTGACCGCAGCGAACGCTGTGGGCCAGCTC
ACTCAGCAGCTCCTGCTCTCCGCAGGCTCAGGTGCACCCTGGGGAGGAGGCTGCCGCCTCGGCCCTGCAG
GCCCTGTGCACAGCTCCTGGGGGTCTCACTGGGGCCCCAGGAGCCGCCACTCTTGACTTTCCAAAGAGCA
GCAGGAGCCAGGTCACCGCCTGCACTCACCACGTGTGTAACCTGGGTGCGTCTCTGCAGGACCAGGGCCT
GCACGGTACCCACTCCCTCCCGAAGGTGCCCCTGCGCCCCCAGGCCTGGGTGCACGGCCAAGCGCCTCTG
CTCTTGCGGATCCAGCACCGGCAGAGAGAGAGGACTTGGCAGAGACAACGCTGCGGTGCCAGGGGCAGGA
CACGGGGGGCTCAACTGCAAAGCCCACAGGCTGTGGAGGTCCCCACAGACACACGGCACGGGCCTCACCT
GAGGAAGGTTTTCGCGTGGGTGAGGTGAGGTGTCACCAACAAGAAATCATCCACCAAACGCAGGAGCAGC
CTAAAATAAGGGAAAATACACAGCAAGGTTAACTTTACACTTTTTACGTAGTATCTGTCTACGAGGGACT
GAATGTCAAACAATTTACACAGCCATAAATAAAGTAACATTCTCCAAAGCGGTTAAATGAAAAACTTAAA
TTTCTTTCCAACAGACGAGCTCTCTACAGTTAACTGCTACAGCAATTCCTCATTCATTATAAGTACTCAG
TGTTTACCATCAGCTTGTGCAATTCTGTGCCAGCTGAAGACGAACGAAGGCCATCAGGCGCGGCCCCACT
TCTCAGACTCTTAGGGAAAAATAACTGAAGACGGTAAGAAAGCTGGGGCTGGGAACCTCGCCCCCTCTGA
GCCACGTGGTGCCCTTTACCAGCATGGCAGCTGTGGTCCTCAGCATGATCCGAGACCCAGATCCTATCCA
CAGGAAGCTGGGCATGGTGCACTGTGTGACCCTCAGGCCCAAGCCCAGCGCCCCATGACCATGGGCCAGA
GGTATCCTGTCCCAGAGGGCTGACCAGTGTGCCGCCAGCTCGAGGACACTTTCCTCCAAATCCCAGAGCA
AGTTGTGTGTACAAGAAATTTTTGTTTCTGTTACATAAACTTATTTCAATCTAGAACTTGAACCTTAATG
AAGAAGAACCTTGATCCACTGTACATGCTATAATTGGAGCTAGAGTTTCAAAAGATGCACAGGAAAAACC
CGGAGTCTTCGAGAGAAATGGCTGTGTGGCCTGCAGGCTTCCTGACGCATCCTTCACTAACTGTCTGCTT
GTTCAGTGATACTATTTTCATAAAAAAATAACTGCTGTCCACATCCTCTCCAGCACCAGAACACTTTTAC
ACTGTTGGTGGGAGTGTAAACTAGTTCAACCATTGTGGAAGACAGTGTGGTGATTCCTCAAGGATCTAGA
ACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGATTATAAATCATGCTGC
TATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAGTAGCAAAGACTTGCAACCAACCCA
AATGTCCATCGATGATAGACTGGATTAAGAAAATGTGGCACATATACACCACGGAATACTATGCAGTCAT
AAAAAAGGATGAGTTCATGTCCTTTGTAGGGACATGGACGAAGCTGGAAACCATCACTCTGAGCAAACTA
TTGCAAGGAAAGAAAACCAAACACCACATGTTCTCACTCACAGGTGGGAACTGAACAATGAGAACACTTG
GACACAGGGTGGGGAACATCACACACCAGGGCCTGTCATGGGATGGGGGGAGTGGGGAGGGATAGCATTA
GGAGATATACCTAATGTAAATGATGAGTTAATGGGTGCAGCACACCAACATGGCACATGTATACATATGT
AACTAACCTGCACGTCGTGCACATGTACCCTAGAACTTAAAGTATTAAAAAAAAAAAAGTAACTGCTGTC
AATAAAAGCCAGCTGAGTTGAACCACATTAGGTTGGCACGATATTTAGGTGTGTGCGTCCTTGGGTGTAG
ACCCCATGCAAGTGGGATGGGCAATGGGCTGAAGAGGCGCCCAGTCCAGGCCACCTGTCGAGGGCCTGCT
GGGAGATGTGGGGCCTCAGGCTGCACCAGCCCCATCTCCCCAAGGACCCTAACGGAACCTGGGTGACGTG
ACAGAAGCTGGTGTGCTTCCTCGGTGTTGAATTCACATGCTCATCATGCAGGGCAGCGGCCCTCCCGCCT
GCTGAGCCCTGAGGCCTCTGGACATGGCCGCTGGACAGAGCCTGCGTGGAGCCCGCAGTCCTCAGGCTGT
GCAACCCCTCCCGTGCGGCTTCATACCAAGAAGGGGCTGCAACCTTGTCTGGTTCCTCAAGACAGAGCAG
TCATGGTCTCCAGAGCACCAGGAATATTAACACTGAATGCATCAAAAGCAAATCAACCCCCACCCAAGCC
CCCCTGGGGAAGAGGAGGCCTCACCCGTCCCGCCGAATCCCCGCAAACAGCTTGTTCTCCATGTCGCCGT
AGCACAGGCTGCAGAGCAGCGTGGAGAGGATGGAGCCCTGCGGGATCCCCTGGCACTGGACGTAGGACCT
GGGGCGGGAAGACACAGGTGAGAGACGGGCAGGGCATGTGCTGGACATGCGTACACTCAAACCGAGCCAC
ACACAGACACAGAACCTCATACACACAAACGACACGTCTACCATTCAGCCGGCAAACACCTCAGAAACAT
ACCAGATGAGACCTCTGAACAAACAATCCCTGCTCCCCACTCTCACCATGCACTGGGGCGGCTGAAACAG
ATCCAGCCACAGGTGTGACCACATCCTTGCTCTGAATCATCAAGGTTTTCTTTCATTAAGGTTTCTTAAA
TCTTAGAGTTTATTCACAGAACCAGACACTTGACCCGGAATGAATGCTTAACCGGACTCCTTTTTTTTTT
TTCAAGGAATTTGTCCACGGTGAAAGACTCATGACCCTACATGTAGCCGCTGCGCGCCAACGGATACAAC
CTTGCCCCTAGTTTCAGCATGACCAACGAGAAGCAGAAACTCTCCAAACAAGGATGCCAAGGGTGCGTTT
TCAGACAAACAGTGAGAGCAGAATAGCCCCGTGGAACCTAAAGGTGCACACAGAAGGCATGGCTGCCACG
CGACCCTCAGCCATCCCCAGAGCCCACAGGACGCCACTCCTGTTGCTAAGAGACGCTTGCAGCCTACTGC
AAAAACAAGACCTGTTATTTTCGGGAAGCGCTATAGGTGGTCACCTTAAAAAGAGGCTTTCCGGCTGGGC
GTGATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGT
TCGAGACCAGCCTGGCCAACATGGCAAAAACCCCTCTCTACTAAAAATACAAAAATTAGCCAGGCGCAGG
GGGTGGGTGCCTGTAATCTCAGCTGCTCGGGAGGCTGAGGCAGGAGAAATGCTGGAACCCGGGAGGCGGA
GGTTGCAGTGAGTTGAGATCGCGCCACTGCACTCAAGCCCAGGCAGACAACAGTGACGTTCCGTCTCAAA
AAAAAAAAAAGAAAGAAAAGAAAAGAGGCTTTCCTTGCTGGTGCAGATATCACAGTGATGGGCAAGAGGA
CTGCACTTTTTGCACAGAAGCACACGCACCAACTCTAGGAGTCCGGCCAGCCCAGCGAGTCAACGCAAGC
AGATACGCCCCTGTGAGCACATGGGATGGGAAACTCTCTCTGTTCTTAGTTTTTGGGGCAACAGGTTTTG
AAGACGTTTTTATTCAGAGGCCAAACTGGACCACGATGGGGACTAGAGCTTCGGGCCTGTCCGTGTCCTA
GGGACAGGACAGACACAGTCACCTCCTGTCTGTCAGGGCATGAGGACGCAGTCATCACCTCACATTCCCC
AAAGCCCTGCCACACGTGGACGGTACGTGACTTGATCCATCTTAATAAAATTCACGACCACGAAGGAGGC
CCGTGGTGGCTTCTCTGGGGAGGTGACTTTGTCAGCGAATTCTGTGGGCCTGGGGGCCGCTTACACACAT
GTGCACACGTGTCCCTCGGCCAAAATTCACTCTGCTGCCATGTGCAATTTGTGTTTTTCCAGAACGTGTG
TACTACTTAATATTTCTAATTATACTTTAATAAATATTATAATTGCTGATACCATTAGTGATTACTTATA
ATGCAATAATTAATAGTTATATTTTTAAATAAAAGCTTCCGAAGCTGTGCACAGTCCTTTATCCGCTGGA
GACGATCCCAGAGAGAGGCCTCCACGTTCCACCTGACTGCGGATGACCTTGCTGATGACCTTGAGTGTGC
ACGAATTTCCTCCGTGCTACCACTCTCCCCAGGCACACACAGGGTCGCAGGCAGATGCCTGCCGGGAGGT
GTGTGGTTTTACTTAAAATCCAGAGGACGTGATGTGGCACCAGGCACTGTGGCTCTACCACCGTGAGTGT
GGCTCACCCAGTGGCTGTGTGACGGCAGCTCTCCCAGGCCGCCTGCCCCATGGCCACCACAGGCCCCCCG
AGAGGAGCAAACTACACGGTCAACCCCGCACTTTCCAGATGGGAAATCTAGTCACAGAGAGAAGAGCCCG
CGCCCTCGCGGGGGTCACACGACAGGGACAGGAATGAGAATCGGATAAAATCCTTTTGTATCGGGAGAGA
GAGATACAAGCGTGTGAGAGCCGGGTGTCCAGCGTCAGTAGTAACTTGGAGCTGACAAGCTGCAGGCTCA
AACGCTCGGCGCACACCTGACCCAGACACACCCCCCGCCCCTCGTCCTCCACGCAGGAGCAACTCCACAC
CCCGCTTGCCATTTCCAGGCCTCGTGTGGCACCTGCTCCGCTCCGGCTGCCGCAAGCCGAGCCATGTTTC
CGGGGCCTCGGGAGCCTGCAGCCCAGGAGCCGGAGGGGGCGGGGGCCAGAAAAGGAGACTCTGGTGGCCC
CGGGCAGAAGGGCAGTGGGGAAGGGGCAGGAGAGAGGTGAGCAGAAGCCCTGCCAGCCCGCCCAGCCACC
CGCAGGGCAATGGCACCTGGCCACCTGACTCACTTGCCCCTGATGCGCACGGCGTGGTGGCACATGAAGC
GTAGGAAGACGTCGAAGAGGCCACTGCTGGCCTCATTCAGGGAGGAGCTCTGCGAAAGCAGACGGGAGAC
ACATGGGAGTGAGCCGGTGGGTGCTGAGACAGGCAGGACCACGTGGCCAAGACCCTCCGTCCCTTTTGGG
GTCAGTGTTTGTGATGAAGTGCGGGGCTGGGCTGGAATGCAGGGCCATCGTGGGCTGGCCGGGCCGAGTC
TCTGCAGACACACATGGGCTTAGGCAGAGTGTGTGACACAGAATGTCTCCTCTGGGCCACCTGTGGGTCC
AGCTGGGCTCACACCCACACAGCCCACCGTGGCCCGGATGGCATATGTGATCCAGGAGTTGCTGCCCAGC
TGCCGGGCACAGGGTCTGGGTCCCAGCAGCCCAGGCCACCTCCACCCCCACCCTGGGAGCCAAGGAAATT
CGCCCAGAGGTCTCTGAGCCTCATGCGGTGGACACGACTGTCCCCTAGAGCCGAGCAAGTGCTAACAGGC
ATCTGCAAAGAGCCACAGGGCCACGTGGACAGACCACATCTGCAAAGGGCCACAGGGCCACGTGGACAGA
CCCAGCACTGAGAGGCCCGCTCAGCGGGGCGTGGCTCAAACACGGCCCGTCCTCCTAAGAAGGGGGACAC
GTTTCCTTTGGCCTCAGACCCAGCACTGAGGGGCCAGCTGGGCAGGACACGGCTCAAACATGGCCTGCCC
TCCTAAAGGAGGGGGACACCTTTCCTTTGGCCTCAAGATCAAAACTGGCAGAGAAGACATTTAGCAAATC
ATGAACAAAGGCACTGCGGAACTGGAGAGAGGCCGCGCAGTCAAACGTGAGCAGGTGCCTGAATGCAGCA
GCTGTCGCAGCCTGGCATGGCCCAGCTCAGATTTCGCCAAGGCACACAGCTCATCATGCCCCCATCACAG
CTCATTCCCCCCACTGCCCCCCAGGGCCAACAGTCTGTCCGGTCATGAGCCCAGTGATTGCCCAGGGGAG
GACCCACTGCTGGGAGTCCGTGCCCAACCCTGCAGGGCAGTGCCCAGACCTGCTCGATGACGACGGCATC
CCTCAGCGGGCTGGTCTCCTGCAGGTGAGCCACGAACTGTCGCATGTACGGCTGGAGGTCTGTCAAGGTA
GAGACCTGCCGGCAGAGGAGAGGGCATGAGCCACAAATGTGGCCTGCCCCGGCCAGAGCTGGGCACTTGT
TTCTTCCGATCAGGACGTGTGGACCTGCGGCCAAGCCCGATGGCGGGATGAAGCCCAGAGAGCGCCTGGG
AAGCTTCTGTTTGGGAAACGGGGGCCGGGGGGCCGAGGACGCAAAGTAGCTACAGACACACCTGGGACTC
CACCTGCAGCTACCACACATCAGACCCCTGTGACCGATCACCATCCACAGTCACCACATCAGACCCCACG
ACCGCCATCCACAGTCACCACATCAGACCCTACGACCGCCATCCACAGTCACCACATCAGACCCCACGAC
CGCCATCCACAGTCACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCACG
ACCGCCATCCACAGTCACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCA
CGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCA
CGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCA
CGACCGCCATCCACAGTCACCACACATCAGACCCCTGTGACCGATCGCCATCCAGTCACCACACATCAGA
CCCCCGGGACCAACCGCCATCCACAGTCACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACA
CATCAGACCCCTGTGACCGATCACCATCCACAGTCACCACACATCAGACCCCACAACCGCCATCCACAGT
CACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACAGT
CACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCACGACCGCCATCCACA
GTCACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACA
GTCACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACA
GTCACCACACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCTGTGACCGATCGCC
ATCCACAGTCACCACACATCAGACCCCCGGGACCAACCGCCATCCACAGTCACCACACATCAGACCCCAC
GACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACAGTCACCACATCAGACCCCACGA
CCGCCATCCACAGTCACCACACATCAGACCCCCGGGACCAACCGCCATCCACAGTCACCACACATCAGAC
CCCACGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACAGTCACCACATCAGACCC
CACGACCGCCATCCACAGTCACCACACATCAGACCCCTGTGACCAACCGCCATCCACAGTCACCACACAT
CAGACCCCCGTGACCGACTGCCATCCACAGTCACGTGGCACAAGTGGCACTCGAGCTCCCGGGCCTCTCC
AGCCCAGTGCTGGAGGGATTGCAGGGATGCAGGTGCAGCCACAGCACAGGCAGGAGAAGAGTCTGAAGAC
GCGGGAGAGAGACCGGCACCCCCACCTCCTATTCTGCAGACTCCCCCAGGACGCTTGTCATTTACTACGG
GACCTGCTAAGCCCCTGCGTCCCCAAGACAGGATGTGAGCAGGCACGTGACACACACTAACACGGACACA
GGAGGCCTCGAGCTTGTGAGGCATCAAAAGACGCGCACGGTGACTCTGTGCTTCAGCATGTTCCCCAGCC
CCCAGGAGCTGGCGGCAGGGCCGTGGGCTAAAACCACATCGAGTACGATTCAACCCTGAGAACCAACCTG
GAAGGCAGTAACAGGAAGGTACATGGGGCCTGCACCCTTCCCAACCCAGGAGCAGGCAACACGCCCACAA
ATAGCCCATGGGTCTGAGGTCGGCGGAAAGCATCACAGAAATCCGTAATTATTCTGGACTCAACACAGAA
AAGCCAATATATCAACACTGACGAGAGGCTGCTGAAGCAGGTCTTTAGCACAGGGTCCCCAACCATTGTG
GTACCAGGGACTGGTTTCGTGGAAGACGATTTTTCCACAGGACAGCAGTGGGGAAGGGGATGGTTTTGGG
AGCAAACGGTTCCACCTCAGATCATCAGGCATTAGATTCCCATAAGGAGCACAGAATCTAGACCCCTCTC
ACGCACAGTTCTCAGTAGGGTGTGTGCGCCTCTGAGCACCGCATGCCACTGCTGATCTGAGAGGGGCGGG
GCTCAGGCGGGAACGCTGGCTCCCCACACCCCACCTAGCCTCCCGCTGTGCGCCGGGTTCCTAACAGGCC
CCAGACCGGTGCCACTCCACAGCCAGGGGCCTCGGGATCCCTGCTTTAGAGGGAAAACGGCAACTTCAGA
TGCTTGTTTAGAAAAGAAAGTTCAAACATCCATAATCGAAACTTTTCCTTCAAGGAGCCGGAAAAACAAC
AATAAACAAAGCCTAAAGGAAATGGAAGGAGGCCATCGATAAACAGCAGACACCAATTACGCAGGAAACA
GCCGGGAAATCAGCACACGTGAAACTCTTCTGTGAAGAGAGTCATGAAATGGAAAGACCCCTAGCGAGAC
CTGGAGAAGGAAAACGGAGGTTGTCAGCACCAAGGCTGCAGGCAGCTATCGCTGCAGATCTCACGGAAGC
TGCAGGAAGCGAGTCTCGGCCGGGCGCGGCGGTTCACACCTGTCATCCCAGCACTTTGGGAGGCCGAGGT
GGGAGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGAGAAACCTCGTCTCTACTAAA
ATTACAAAAATTAGTCAGCATGGTGGTGGGCGCCTATAATTCCAGCTACTTGGGAGGCTGAGGCAAGAGA
ATTGCTTGAACTCAGGAAGCACAGGTTGCAGTGAGCCAAGATCACGCCAAACCACTCCAGCCTGGGCAAA
AAAGAGCGAGACTCTGTTATCAAAAAAAAAAAAAAAGAAAGAAAAAAAGAAAGAAAGCAAGCCTCCAACT
CGCAGGGGAATTCCAAGGACGGAGCGTAGCCAGGGCCACATCCAGGCCAATGAACACAAGGAGGCCTGGA
AGCCCTGCCCACCGGCCACACACCACAGCAGGCACCACACGACCCCAGAGTGGAAGAAACAGAACAGGGA
GCCCAGGGGAGGCCTCCACACCCCTGACTTACTATAAACCCGACCATAGTTCAAAGGAAGATATGGTCTC
CTCAATAAAGCTGTTGGAGCACCTGCAGACCCACTACAGGAAGAAAGCTCGCCTTGAACTCTGTGTTACC
CCACTCATAAAAACCAATCCCACAGATCCCCACCTATCCCACACATGAAAACCAATCCCACAGATCTCCA
CCTACCCCACACATGAAAACCAACTCCACAGATCCCCACCTACCCCACACATGAAAACCAATCCCACAGA
TCCCCACCTACCCCACACATGAAAACCAATCCCACAGATCCCCACCTACCCCACACATGAAAACCAATCC
CACAGATCTCCACCTACCCTACACATGAAAACCAACTCCACAGATCCCCACCTACCCCCACACATAAAAA
CCAACTCCACAGATCCCCACCTACCCCACACATGAAAACCAATCCCACAGATCCCCACCTACCCCACACA
TGAAAACCAATCCCACAGATCCCCACCTACCCCACACATGAAAACCAATCCCACAGATCCCCACCTACCC
CACGGATGAAAACCAATTCACAGATCCCCACCTACCCCACACATAAAAACCAATCCCACAGGTCCCCACC
TACCCCACACATAGAAACCAATCCCACAGATCCCCACCTACCCCACGGATGAAAACCAATTCACAGATCT
CCACCTACACCACACATGAAAACCAACTCCACAGATCCCCACCTATCCCACACATGAAAACCAATCCCAC
AGATCCCCACCTACCCCACGGATGAAAACCAATTCACAGATCCCCACCTACCCCACGCATAAAAACCAAT
CCCACAGATCCCCACCTACCCCACGGATGAAAACCAATTCACATATCCCCACCTACCCCACACATAAAAA
CCAATCCCACAGATCCCCACCTACCCCACACAAGAAAACCAATCCCACAGATCCCCACCTACCCCGCACA
TGAAAACCAATCCCACCTACCCCACACATAAAAACCAATCCCACAGATCCCCACCTACCCCACGGATGAA
AACCAATTCACAGATCTCCACCTACACCACACATGAAAACCAATCCCACAGATCCCCACCTACCCCACAC
ATGAAAACCAATTCCACCAATCCCCACCCAGGTTTGCAAGCTGACACAGTAAAGACTGTTCTAAAAGGAG
GCGCAGAAGCAACGTCACCACAACCTCAATACCTTGAGTTCCTGCAGAGAACACAAACAGCTTTAGCCAC
AAACAGCTGATAAAGTGGACTGCGTTACTGGACTGTGTTAGTGGACTGCGATAGAAGTACAATCTTCCAG
TCCTCAAAAGGCTTGACTTGAGAGCACAAAAGCAAGACACACACGGCACAGAGATTCACAGTGCACGCAT
GTGATGCCACACTTGCAGCAGAACACACAAAGAGCTCCTGCAAGCCGATGATGGCAGGCAGGCGCCCCAT
ACAGAGCGGGGCAGGACGGACAGCCACCTCCCGCAAGAGCCCCGGGGCGGCCAGCACGGGAACACTGTGG
GCACGTGGGCATCAAGAGAGCCCCCTGCACAATCCCACGAGGCGGCTTCGACACCTTCAGGCCAGCGGCC
ACCGGAGGCATCGCCCTCACAAGCAGCCAGCCGGGGTGTCACTGTCACCCCCCTGGAAACTCCCACAACA
TCCCTAAAGCACGTCTGTGACCCAGCAACCCCACCCCTGGAATTCACCCAGAGGCGAGGGCCTCTGACCC
CTGGGACACTCCCAGAACCCAGCAGGCTCACAGCAGGCGCAGCCGTGCAGTCCGCACCCAGGAGCCTCCA
CAGCAGCGGGAAGGATACATCCACGTGGCGAGTTCCACAACGGATGCCATTCATGGACAGAACGCACAGC
TGAGGCGTTCAGCATAGCTGAGGCTCGAACCCCAAAACCCACCTCCTGCCTGATCTCACTCACATGGAGA
CCGGGAGAGGGAGACCATGGAGGTCGAGGTCGGAACGAGGGTCACGGTGGGGGCGGTAGCTTCCGCTGCA
GCGGGGATGTGGGGGGGGGTCTCCTGGGCTCTGGTGACTTTCTACACCCGGGCACAGGTGGGCGGTGGGG
ACGGGGGGGTCTCCTGGGCTCTAGTGACTTTCTACACCTGGGCACAGGTGGTGGCCATCAGCTTTCCATG
AGGGTAAAATTCTGCTGAGATTTGCAAGTAGCTGCGATAGCTCAAGAAGTCAGAGAAAGAGGTCCTTGTG
GGTTTCCACATGTGCCTCTCCCCAGACCGAAGCTCCAGGGATACTTCTTCACCTCTGCACCCCGGCCTGG
CACGACTTTGAGGGCTTACCCCTCCAGCGTGCTCATGACCACTGGGTGGGAACCCAAGCCCAGGGCCCCT
TTCACCCCTGCCGAGCCCCAAGGCCCCCGGCCGCTCTGGGAGGAGTGTGTCCCGGGGAGCGAGGCCTGAA
TCAGCCTTCCTATATCTCATGGAGCCGGCATAGGCCAGACTGGGGTCCTGGGGGTGCCAGGGGTCCAGGA
AGGTACCACCAGCATCCCTACTCTCCTCTCAAACCTGGCTTACAGTCTCCAAGGCCCAGCCCTGTGACAG
GACAGGGGCACCCATGCTAGAAGTGAGGACCCTGAATGTGGAGCTCCCCAAACCAGCACCCGAGAGCGTG
AGGACAATGGTGCGGACCATGCCTGGAGGAGGAAGGAGTAAGGCCAAGGGGCCACACACACCCATGCCAT
AGACACGCATATGTCACGGACACATGCACACACACACACCACAAATAGGCACATCACAGACATGCAGCAC
ACAGCATGAACATGCACGTGTCACAGACACACACACATGCACACCACAGGCACACACACCATGGACACAC
ACGTGCCACACACACACACACCACAAATATGCACGCCACAGATACATGCACCACGACACACACGTGCCAC
ACACGCATATCACAGATGTGTAAATCATGGAAGTACCTCCACCACAGAAACGCATCACAGACACGACTGC
ATTCTAGACACATTCATATCCCAGAGACACACATCCTGGACACGACTATCACACGTGAACCTTACGTGGC
TCTTGAAGGCCTTGCGGACGTGCCCATGGGCGGCCTTCTGGACCACGGCATACCGACGCACGCAGTACGT
GTTCTGGGGTTTGATGATGCTGGCGATGACCTCCGTGAGCCTGTCCTGGGGGATGGTGTCGTACGCGCCC
GTCACATCCACCTGTGTGAGTGGAGGCGAGGAGACTGACAGTGGCCACGCAGAAACTCAGACATCACCTC
TGCCCTCAGGGCCTGGCCTGGCGGTGTCCCCCACTCTCTCTCTGACCCCCACCACTCCAGACCCCAAGGG
CAGGGCGGGCTGTGTCCCCTCTCTGAGCCTCAGGACAGGAGACCCCTGGCTCAGGACTGGGGTGCAAGGC
ACCGGGGCCTGGTGGCTGAGCCGTTGCGGTTCCTTCTCTGACGGAAACTGGAATCCAGTGGGACCCTCCT
TGGGAATAGGAGCCCGGGCAGTCAGGGTGCACAGTCGGCCCCATGTGCTGCAGGAAAGGCTGAAGGCCTC
CACCCTAGGTGCCAGGTGTGTCCTCAACAGTGACAGGGTCACCTGCACTCCCTGCGGCCCACCCAGGAGT
ACCTCCTCCACCCAACATGAGGTGCCAATCAGGCAGCCACTCCCAAGGTCCAGCAGGGCTGCTCACGGGG
GTCCCCGGCACCCACCTTGACAAAGTACAGCTCAGGCGGCGGGTCCTGGGCCCGCACACGCAGCACGAAG
GTGCGCCAGGCCCTGTGGATATCGTCCAGGCCCAGCACAGAGGCGCCCAGGAGGCCGGGGCGCCGCGCCC
GCTCGTAGTTGAGCACGCTGAACAGTGCCTTCACCCTCGAGGTGAGACGCTCGGCCTGGCGGGGACAGCA
TGGGAGACAGTCAGGAAAGTGGATCCGGCCAAGTGCCCACCCCACCATAGGGACCCAGGGGAGAAGCAGC
CCCTCCCCAGTGTCCCCAGCCACCCAGACCCGGGACCTAGAACCCCTCCCAGCTTCCTCAGACCCTGTTT
GAAACGGGTTCCTGGCCGCATGTGTGTTGCACACGGGATCCTCATGCCACACCTCTGTCCACCTCACCCC
ACACTCTCCTCAGATGACGGGGTCACCGCAGCCACCGCAGCCACAGGGGTGGGGTGCAGGAGCCGTGGGG
CAAGGTCCAGGATCCTCAGAGCCCGGTGGGCTCCTGGCAGTCGTGGCCTGGTCCCCGGGCCCCGTAAGCG
GAAGCGCACGGAGGCTGCGCACCACAGCAGGACACGGATCCAGGACCTCGGGCCGTGCTGCATCCAGGCC
CTGGCCCGGCTGCTTCTTGTGGTCCTCAGAGCCTGTCCCTGCCCCAGGAGCTCCCCCTACACCCCCACGC
TGCTTTTCTGGAGGCACCGGCACCTCGGCCACCTCACTGTGCGCACAAATGGGTTGGCGCCGTGCCATGG
CCCTGGCTGTGTCCCGTGGCCCCTCCTCCGGGCCCTTCATCTAAGCTGATACCAAATGTGGGGCTCAAAC
GCACTTCTGTTTAAAAAGGAAGTTAAACCAAAGCACAGCCACCCTCTTTTCTCTGCGGAACGTTCTGGCT
CCCACGACGTAGTCCATGTTCACAATCGGCCGCAGCCCGTCAGGCTTGGGGATGAAGCGGAGTCTGGACG
TCAGCAGGGCGGGCCTGGCTTCCCGATGCTGCCTGACCTCTGCTTCCGACAGCTCCCGCAGCTGCACCCT
CTTCAAGTGCTGTCTGCAATAGAGAGCCCCTCAGGAGGCTTGCTCAGCCAGACAACAGACTAGGGGGAAG
CTCACGGGAAGCCACAAGCCCCCACCGACTCAGTGAGGGCTCAGGGCACCCACGGCAGCACACGCTGAAG
GCCATGCCCGGGGCCACGTCCACCCATGCCAGCCAGACGCCTCTGAGAGCCCCTCTACTTGCAGGGCACC
TGGACACCTGGTCCTATAGTCAACCCTGGGGACGCCCAGTCCGGCGGTCAACCCCCAGGGTGACTGTCCC
ACCATCAGCACCAGGGAGCCTGGTCCCAGGCTGCATCTGGGGCCACGTGAACCCATGCCCCTCCACACAG
GATGCCTGTCCCTCTGGTACAGCCACTGGGGTAGCCCAAGGCTGGCCCCAGGCAGGACCCCCAGGTAGAA
AGAGCCACATCCCTTCAGATGGAGAGGGCGGGAGAGGCTGCTCAGGGCAGCTCAGCCAAGGAGCAGAATC
AGCTCTCATGAGCCCACCAGTCTCCTGACACCTCTGCCCTTTGGCCTTTTCCCCCAAAACCACCCATGGG
GGCACGGGGGCTGGAGCGGCCACACCTGGACCTGGGCATCTGTGGCTGACAGCCTGGCACTCCGTGGACA
CTGGGGCCGCGGGTGCTCCGGAGCTGGTGCCCTGACCGCAGGCCGCAGGCCCAGCAGAGTAGAAAAGGCA
CGGTACCCTGTCCAGGGAGGAGGGGCCTCCAAGGCCCCCCAGGCAGAACAACAGTCCCAGTAGTGACAAG
GAGCATCTTGGGGACCACCACGTCTGTCTGCTCCTTCCGGTCACCCCAATTAAATTCTTTCCAAAATACT
GGTCAAATGACCATGTTGGGTCGCACACCATTAAATACGTGTAAAGTCTAAGTAAGGTGCATTGTGTATT
AACTTGTTCCCACAGGGAAAGCCCTGACCCTCCCCCAGATGCAAGGAAATGGCCCCAGCACCACGTCGGG
GTCCCCAGCCCAGAGGCTGTGTTACCTCTGACGAGGTCTGCTGCCAGCTCCCTCTGCAGACATCCTGATT
TGGGGCATGGGGTGTCACAAGGCCCCCCAGGGACTCGAGTGTGCAGGGGAGCTGGGGAAGCCCTGATCTT
CTGACTAAAGCCCTCCACAGTCAGCCTGGGCGGGACACGGAGAAGCTAATACCATGGCCTGGGCTCAGCC
AGGCTGGCATCTCCCAGACCAGCGCTCCCGTCCCTCACTGATGCAAATCCAGCTTGAATCTGTCACAATC
TCACACTCTCATCAGCCGAACATTGCAGACAAAATCTCACAGCCATTCAAATGCAGCCACCTAGAAGTTA
GCTCATGGTGGAACTCTCCTATCCCCAGGTGCTCCCTGCACAGGTGCTCCCTGCAGTGAGTCGCCAAGTG
GGTGGGATTTTATCCTCTCATGACCTAAATCCAATAGATTGAAGATTCATACAGAACAGCATGAATTAAA
AGAGAATCGGGGGCTGGGCACGGTGGCTTAGCCTGTAAACCCAGCACTTTGGGAGGCCAAGGTGGGTGGA
TCACCTGAGGTCATGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAGTACAA
AAATTAGCCAGGCGTGGTGGCAGGTGCCTGTAATCCCAGCTACTTAGGAGGCTGAGGCTGGTGAATCGCT
TAAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATTATGCCACTGCACTCCAGCCTGGGCAACAGAGTG
AGACTCCATCTCAAAAAAGAAAAAAAAAAGAGAGAGAGAATCAGACCCACATCCCAGGGAAAGGCAAGGA
GGCTAGTGGTAGTGTTTCCATCTAATTTAAATCCCTTCTGCTTTACAAACCCTAGAGACCACTTGGCACA
AACTCCTGATTTTACAAGTAAGAGAACGTGAGCTCCAGGCAGTCAGAGCCTTGCACAGAATCCACTTGGA
CCAGGCCTGTGACGGGGCCCCTGGCTCCCAGCCCAGAGCTGCACAGCCAGGGAAGCACAGGCAAGTGGAG
ACAGGCGCATGCTGAGGCCGGGCTGGTGTTCCAGGACTTCGAGAAGCAGAGGCCTGGCGTGGGGATACAG
TACCTGATTCCAATGCTTTGCAACTTGCTCCAGACACTCTTCCGGTAGAAAAAGAGCCTGTTCTTTTGAA
ACGTGGTCTCCGTGACATAAAAGAAAGACCTGAGCAGCTCGACGACGTACACACTCATCAGCCAGTGCAG
GAACTTGGCCAGGATCTCCTCACGCAGACGGTGCTCTGCGGCCGGAACACAGCCAACCCCTTAAACGAGA
AGGACATGCCACATCCAGATCACCGAGGGCCTGGTGACCTCACCCCGGACCTGCACCATCCGGACACCGC
ACATCCAGCTCACCAAGGGCCTGGCGACCTCACCCCAGACCTGCACCATCCGGACACGGCACATCCAGCC
CACCAAGGGCCTGGCGACCTCACCCTGGACCTGCACCATTCGGACACGGGGACACCGCATATCCAGCTCA
CCGAGGGCCTGGCGAACTCACCCCGGACCTGCAGCATCCAGACACCACACATCCAGCTCACCGCAGGGCC
TGGCGAACTCACCCCGGACCTGCACCATCCAGACAACACACATACAGCCCACCGCAGGGCCTGGCGACCT
CACTCCGGACCTGCACCATCCGTACACTGCACATCCAGCTCACCGCAGGGCCTGGCGACCTCACGCCAGA
CCTGCACCATCCGGATACAGCACATCCAGCTCACCGCAGGGCCTGGCGACCTCACCCCGGACCTGCACCA
TCCGGATACAGCACATCCAGCTCACAGCAGGGCCTGGCGACCTCACCCCAGACCTGCACCATCCGGACAC
CACACATCCAGCTAACCGCAGGGCCTGGTGACCTCACCCCGGACCTGCACCATCCGACACCGCATATCCA
GCTAACCGCAGGGCCTGGCGACCTCACGCCAGACCTGCACCATCCGGATACAGCACATCCAGCTCACTGC
AGGGCCTGGCGACCTCACCCCGGACCTGCACCATCTGGATACAGCACATCCAGCTCACAGCAGGGCCTGG
CGACCTCACCCCGGACCTGCACCATCCAGACACCGCACATCCAGCTAACCGCAGGGCCTGGTGACCTCAC
CCCGGACCTGCACCATCCGGACACCGCATATCCAGCTAACCGCAGGGCCTGGCGACCTCACCCCGGACCT
GCACCATCCGGACACCCCACATCCAGCTCACCGAAGGCCTTGGCTACCTCACCCCGGACCTGCACCATCC
AGACACCGCACATCCAGCTCACAGCAGGGCCTGGCGACCTCACGCCGGACCTGCACCATCCGGACACCAC
ACATCCAGCCCACCAAGGGCCTGGCGACCTCACCCCAGACATGCACCATGCAGACACCGCACATCCAGCT
CACCAAAGGCCTGGCGACCTCACCCCAGACCTGCACCATCCGGACACGGCACATCCAGCCCACCAAGGGC
CTAGCGACCTCACCCTGGACCTGCACCATCCGGACACGGGGACACCGCACATCCAGCTCACCGAGGGCCT
GGCGAACTCACCCCGGACCTGCAGCAACCGGACACTGCACAACCAGCTCACCGCAGGGCCTGGTGACCTC
ACCCCAGACCTGCACCATCCGGATACAGCACATCCAGCTCACAGCAGGGCCTGGCGACCTCACCCCGGAC
CTGCACCATCCGGATACAGCACATCCAGCTCACAGCAGGGCCTGGCAACCTCACCCCGGACCTGCATCAT
CCGGACTCCATACCTCCAGCTCACCGAGGGCCTGGCGACCACACCCCAGACCTGCACCATCCAGACGCCG
CACATCCAGCTCACAGCAGGGCCTGGCGACCTCACCCCGGACCTGCATCATCCGGACTCCATACCTCCAG
CTCACCGAGGGCCTGGCGACCACACCCCAGACCTGCACCATCCAGACGCCGCACATCCAGCTCACAGCAG
GGCCTGGCGACCTCACCCCGGACCTGCATCATCCGGACTCCATACCTCCAGCTCACCGAGGGCCTGGAGA
CCTCACCCCTGACCTGCACCATCCGGACACCGCATATCCAGCTCACAGCAGGGTCTGGCGACCTCACCCC
GGACCGGCACCATCCGGACTCCATACATCCAGCTCACCGAGGGCCTGGCGACCTCACTCCAGACCTGCAC
CATCCAGACACCGCACATCCAGCTCACCGCAGGGTCTGGCGACCTCACCCCGGACCTGCACCATCTGGAC
ACTGCACATCCAGCTCACCGAGGGCCTGGCGACCTCACTCCAGACCTGCACCATCCAGACACCACACATC
CAGCTCACAGCAGGGCCTGGCGACCTCACCCCAGACCTGCACCATCCAGACACCACACATCCAGCTCACA
GCAGGGCCTGGTGACCTCACACCGGACCTGCAGCATCCGGACACCCCACATCCAACTCACAGCAGGGCCT
GGCAACCTCACCCCAGACCTGCACCATCCGGACACCGCATATCCAGCTCACCGCACGGTCTGGCACCGTC
TGGCGACCTCACTCCAGACCTGCACCATCCAGACACCGCACACCCAGCTCACCGCAGGGCCTGGTGACCT
CACCCCAGACCTGCACCATCCAGACACCACACATCCAGCTCACAGCAGGGCCTGGCGACCTCACCCCGGA
CCTGCATCATCCGGACTCCATACCTCCAGCTCACCGAGGGCCTGGAGACCTCACCCCTGACCTGCACCAT
CCAGACACCACACATCCAGCTCACAGCAGGGCCTGGCGACCTCACCCCGGACCTGCATCATCCGGACTCC
ATACCTCCAGCTCACCGAGGGCCTGGAGACCTCACCCCTGACCTGCACCATCCAGACACCACACATCCAG
CTCACAGCAGGGCCTGGCGACCTCATCCCAGACGTGCACCATCCGGACACTGCACATCCAGCTCACTGAG
GGCCTGGCGACCTCATCCCGGACCTGCACCATCTGGTACAACAGCCATGGCCATGGGAAGCCCAGCAGGT
CCAGGCCGAGATGGCCACGCACGGGACCTACACACGGGATCCCGCAGACAAAGCTCAAAAAATGTCAAAT
GTCCTGTGAGTGATGCTCCCACCAATAACACCCTAAAATGATGAGGTGTGGACATGCTGGGCTTCAGTAA
AATCTATTATTACATTAATTTCACCTTTTCTTTTTTACTTTTTTAATGTGGCTACTAGAATTTTTTTTTT
TTTTTTTTTTTTTGAGACAGAGTCTCGCTGTGTTGCCAGGCTGGAGTGCAGTGGTGCAATGTCGGCTCAC
TGCAACTTCCAACTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCA
CCCGCCACCACGCCCAGCTAATTTTTGTGTTTTTAGTACAGATGGGGTTTCATCATGTTGGCCAGGATGG
TCTCGACCTCCTGACCTCGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCA
CCGCGCCCAGCCTAGAAATTTTAAAATTATCCACATGGCTCACGTCATGCTCCTGTTGGGCGACAACGGC
TCGGAGCCTCATCCTTTGTCCTGGTTCCCAAGCAGAAGGGAGGAAGCAGACACTCCCCCGCCAGGCAGCA
CCGTCAGAGCTGGCGCCACACCGCAGGTTTGCGCGATTTCAAACTCGACACCGCGGAGCCACCAGACCCC
GACATGCCTGGGGTTTTCCAGGCTGAACCCAGGCCGAGCGGACGTTGCTGTCACTCACTGGCTAAGGAAC
GCTGGCCACGTGGTGCTCCAGACACTCACGGGCCAAGATGACCGCCCTCCTCGTGAGTCTCCACATCTTC
ATCTGTGCATCATAAGCAGAGGTCCCCGGACGTCGCTAGATGCCATGGAGGCCAGCACAGGTAAAGCTGG
GGTTTACCAGCAATAACAAGACAGAAGAACCACGCAAAGGACAAGGAAGGGGACCCCAGACGGCGGGCCT
GAGACAGAAGACAGACGGGGAACAAAGGAGGAAAAGCAGGGCGGGGGCAAAGCTACAGAAACACTCAACA
CGGAAAACAATATTAATAATGCTTAGCTTGTGGGGGTGTCAAGATGCCTGAGATAGAACTAAGTCAGCAG
GGAAAACAGCACACAGGCTGGGGGGTGGCCAGAGCTAAAATACACTAAGGGTCTTATTGCTCAGGACAAG
GGTAGCAATGTTTCAGACTTCATTTTAAAAGATCAAGGTATGCCGGGCACGGTGGCTTGCACCTGTAATC
CCAGCACTGTGGGAGGCCAAGGCGGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACAT
GGTGAAAGCCTATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGC
TACTCATGAGGTTGAGGAATGAGAACTGCTTGAACCGAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTG
CCATTACACTCCAGCCTGGGTGACAGAGTGAGACTGTCTCAATAAACAAAAGCAAACAACGACAATAAAA
AGATCAGGGGGTAACACTAAGCAAAGAGAAATAAAAGCAAATGCCCAGTGACCAGGAGGCAACGAGAGGA
TCAACACACACTCGGCAGGAAACGCACATGGCAACCCAAGAGGTGGTGAGAAACAAGGGAACGAGGACAT
GCAACAGGCAAGTGGAGAATCAGAGTGCACCAGGCGGGTCTCTAGTGACAAAAAAATGAAAATAAATCAG
GTTATCCAGTTAAACAACGACTGTCAGACTGGATTGGAAATTCACCTACATGCTGTTAACAGGACATACC
CACACTATAAGAATATAAAAGTGTTGAAAATTAGGCCAGACATGGTGGCTCATGCCTGTAATTCAGCACT
TTGGGAAGCCGAGGTAGATGGATCCCTTGAGTCCAAGAGTTTGAGACCAGCCTGGGCAACACAGCAAGAC
CCTGTCTCCAGAAAAAATTTAAAAATTAGCCAGGTGTAGCGGTGCGTGTCTGCAGTTCCAGCTATTCAGG
AGGCTGAGGTGAGAGGACGGCTCAGGCCAGAAGGTAAAAGTTACACTGACCTGTGATCACACCACTGCAC
TCACCCTGGGCGACAGACCAAGACTCTGTCTCAAAAAAAAAAAATATATATATATATATATAAATTAAAG
GCAGAAAACAGACACAGCAGGAAAATACTAATCAAAAGAAGCCCAGTGTGGCAGTACTAAGAGCAATTTA
AAAAAAGAATTACTAGATTACTAGAGACATAGAAGTCTCCAAAAGATTCACTCATCAGGAAGATAAAAAT
TCTACCACGTGCATGCACCTAACAATGCCTCACATAAATGCTACCAAACGAGAAGAAATGAACAGACCCA
TCCCCCAGGTGAGGGACTATGGCCTCCTTCTTGGAATTTCATGCATCTAGAAGGAGACAGAAGCTTTGCA
CTGGACCTTAATAAGCTGGATATAGTGAACATGCATGCCCACTATTGACAGGATGTCAAATTTACAATGG
ACAGTTCTGGAAACCATGCACACACTAGATCACAAAGCAAGGCTCCGCAAACTTCAAATAATTGGTATTA
TACAGACCACTACACAACTGAGTTAGAAATCAATAATAAAATGATAACTTAAAATACTCTACGTATCTTG
ATACTCTACATATCTTGAACATAAACAGTGTTCAAATAACTCACTGCTCAAAGAAATCACAGAATAAGCT
AAAGAATACTTAAAAGTCACTGATATCAAAATGATTTCACGTCAAAACACAGCGTGCACAAAGAAAAAAA
TCACAGAATAAGAATACTTAAAAGAAGTATTAACACTTTGAAGTATTTTAAGAACACTTGAAAGTGGCTG
ATGTTGAGATTACTTCACATCAAAACACAGGGTGCAGGTAAGGCAGCACTTAGAGGGAAAGGCATGACTA
AACTAAGAAGCTAGAAAAGGAATGAAAGAATAAACCAAGAAAAAGCATACAATGGAGAGATAGAAACGTC
AGAGGTAAATCAGTGAAATTCAAAACTAAGACCCAAGAGGGAAGTCTGACGAAGGCTGGCGGAGACACCG
GCCCTCCACGTGGGTCTCAGAGCAGGAGACAGACAGAGACACTCCAACCTGTGGCTGGACGTCAATCCAT
GTGAGGGGGCGACTGGAGGCAGAGCCCAGCCTAAGCAATGAGCGGCAGGTGCCCAGAATAAGGTGACAAG
CGTTGCCACCCACCCAAGGGGGCCAAGCAGAGGGGCAGCTTGGGAGAAAACAGGACAAGTGAGGGGGCTG
GGGTGACTTGCTTTCCTTCAGGGCACAGAGAACCCTTTCTGGGATGTCTCCAGCAACACGTGGCAGCAGA
CACAGGCAGCCCAGAGTCCAGCCTCGGCATGAGACAAGCTGGGAGAGGAGTATTGGCAGCATGCATGTGG
CGGGCACGTGGTGAGCAAGCCAGGCCCAACAGAGGCAAGCGGACCTGAAGCTGTGGCTGCAGTGCCTGGC
ACGCGGGAGGCGAGAGCCTGCAGTCCCGTGTCCCCGTAGCAAAATGGAACGGAGAGGTGACCAAGAAGAG
CCGAGCATCAGAAAAGATAGGCTTGGGGACCAGCACTGCGCCTGCACCATCTACCCAGGCAATGGGCAAC
CGGCGCAGCTGTGGCTATAGAAAGAGCAAACATTCAGGAGCAAGCTCAAGTGAGCAAACGCCAAGGACAC
CTGGGGACAGAGCCTCACTCACCCTACACGAGACAGGGACACCCAGGGACAGCGCCTCACTCACCCTGCA
CCTGAGAGGGACACCCGGGGGCCGCAACTCACTCACCCTACACGTGACAGGGACACCCGGGGACGGCGCC
TCACTCACCCTACACGTGACAGGGACACCCGGGGATGGCGCCTCACTCACCCTACACCTGAGAGGGACAC
CCAGGGACGGCGCCTCACTCACCCTACACGTGACAGAGACACCCGGGGACAGTGCCTCACTCACCCTACA
CGTGACAGGGACACCCGGGGACGGGGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGACGGCGCC
TCACTCACCCTACACGTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTACACGTGACAGGGACAC
CCGGGGACGGCGCCTCACTCACCCTACACGTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTACA
CGTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTGCACGTGACAGGGACACGCGGGGACGGCGCC
TCACTCACCCTGCACGTGACAGGGACACCCGGGGGCCTCGCGTCAATCACCCTGCACGTGACAGGGACAC
CCGGGGACGGCGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGACAGTGCCTCATTCACCCTACA
CGTGACAGGGACACCCGGGGACCGCGCCTCACTCACCCTGAACGTGACAGGGACACCCGGGGACAGTGCC
TCACTCACCCTGCAAGTGACAGGGACACCCGGGGGCCGCGCCTCACTCACCCTGCACGTGACAGGGACAC
CCGGGGGCCGTGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGGCCGCGCCTCACTCACCCTGCA
CGTGACAGGGACACCCGGGGGCCGCGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGGCCGCGCC
TCACTCACCCTACACGTGACAGGGACACCCGGGGGCCGCGCCTCACTCACCCTGCACGTGACAGGGACAC
CCGGGGGCCGCGCCTCACTCACCCTACACGTGACAGGGACACCCGGGGACAGTGCCTCACTCACCCTACA
CGTGACAGTGACACCCGGGGACCGCGCCTCACTCACCCTACACGTGACAGGGACACCCGGGGGCCGTGCC
TCACTCACCCTGAACGTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTACACGTGACAGGGACAC
CCGGGGACGGCACCTCACTCACCCTACACGTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTGCA
CGTGACAGGGACACGCGGGGACGGCGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGGCCTCGCG
TCAATCACCCTGCACGTGACAGGGACACCCGGGGACAGCGCCTCACTCACCCTGCACGTGACAGGGACAC
CCGGGGACGGTGCCTCACTCACCCTACACGTGACAGGGACACCCGGGGACCGCGCCTCACTCACCCTGAA
CGTGACAGGGACACCCGGGGACAGTGCCTCACTCACCCTACACGGGACAGGGACACCCGGGGACCGTGCC
TCACTCACCCTGCACGTGACAGGGACACCCGGGGACCGCGCCTCACTCACCCTGCACGTGACAGGGACAC
CCGGGGACCGCGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGACCGCGCCTCACTCACCCTGCA
CGTGACAGGGACACCCGGGGGCCGCGCCTCACTCACCCTGCACGTGACAGGGACACCCGGGGGCCGCGCC
TCACTCACCCTGCACGTGACAGGGACACCCGGGGGCCGTGCCTCACTCACCCTGCACGTGACAGGGACAC
CCGGGGACGGCGCCTCACTCACCCTGCACGGGACAGGGACACCTGGGGACCGCGCCTCACTCACCCTGCA
CGGGACAGGGACACCCGGGGACAGTGCCTCACTCACCCTACACGTGACAGGGACACCTGGGGACCGCGCC
TCACTCACCCTGCACGTGACAGGGACACCCGGGGACAGTGCCTCACTCACCCTATACCTGGGAGGGACAC
CCAGGGACGGTGCCTCACTCACCCTACACGTGACAGGGACACCTGGGGCCGCGCCTCACTCACCCTACAC
CTGAGAGGGACACCCGGGGACAGCGCCTCACTCACCCTACACCTGGGAGGGACACCCAGGGACGGTGCCT
CACTCACCCTACACGTGACAGGGACACCCGGGGACCGCGCCTCACTCACCCTGCACGTGACAGGGACACC
CGGGGACAGCGCCTCACTCACCCTGCACGGGACAGGGACACCCGGGGACCACGCCTCACTCACCCTACAC
GTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTACACCTGAGAGGGACACCCGGGGACAGTGCCT
CACTCACCCTACACGTGACAGGGACACCCGGGGACCGCGCCTCACTCACCCTGCACGTGACAGGGACACC
CGGGGACAGTGCCTCACTCACCCTGCACGGGACAGGGACACCCGGGGGCCACACCTCAATCACGCTGCAC
GGGACAGGGACACCCGGGGGCCGCGCCTCACTCACCCTACACGTGACAGGGACACCTGGGGGCAACGCCT
CACTCACCCTGCACGTGACAGGGACACCCGGGGACCACGCCTCACTCCCTGCATAAGCCAGGGGCAGATT
GTGACCTCATCTGAAGTCAGAGAACAGCAATGACAGGCAGAGTCCTGATCAGAGAACTCAAACTCTCCTC
AACGAAGGAAGCTGGAGCACAAAAAGCAAAACTGGGTTGCATGACGCTTATCTGACTCGGCGTGGTCCAC
CTGAGCCGCAGCAGGTGTGAGGCAGCTGCCGTTCGATGGGTAGGGACTTCCAGTCACGCAAGACGCAGCA
TTTCAAGCAACCTGCTGTAAACACCGCCGAGTTAGCAATTCTGCACTGTACACAGAAAACGGTGTTAGGA
GTGCCAATCTCATGTTATATGACTTTTGCCACCATAAAAAGAAAAAAAGAAAAAAAAGAGCCCCAAGAAG
GTCACCCTCCTTGTCTGCATGGCCGGAAGTCTTACATGTCTTGGGAGTTTGTGGGGAGGGGGTGAAATCG
GGACTTCTTCTAGCTGCCACGGTAGGGCCTGGGAGCACTGGGAGCCAAAAGGGGGCTGGAGCGGAGGTTC
CTCAACATCAAATCCAGAAAAACAGGGTGGGGACACGGCAGGGCCCAGCAGCACCATCCCCTGAACACCC
ACAAACACTGTCCCTTCCTCAGCAGGTGGAGCCATCTGCTGTCCTCTGCTCCCATGTGGCCCTCTTCATA
CCTAAAGATGGGACCAGGATCTGTGCTGGAGAACAGTCTTATCTCCCTCCCTCTACCCTGTCCTGGCACA
ATCAACGAACACTTTTTTTTTTTAAAGACAGAGTTTCACTCTTGTCGCCCAGGCTGGAGTACAATGGCAC
AATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCT
GGGATTACAGGCACACACCACCATGCCCAGCTAATTTTTGTATTTTTAGTACAGATAGGGTTTCACCATG
TTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAGTGCTGGGAT
TACCGGCGTGAGCCACCGCACCTGGCCGTCAACACACAATTAAATCTTAAACACAAACCTGCATATTGGC
TGACCACGTGCACCTGCAAAACCCTTACCTCCCACCCCCAGGAAGAGGGGGTTCTCGTCCCCACCTCTCA
TTCCCACCCTTGAAATTGCGAAGAGGATTATAGGTAACCTGCAGGCACCCTCGCCAGAGCGTCTGTGCTT
CCAGACACTTCTCCCCATTGCCGGCAACCCGGCTCCACTGCCGCGCCCAGCCTCCTCTGTTCACTGCTCT
GGCCTCGGCGCCTGGAAACCGCGTGTCCATCAAAACGTGAAGGTGAACCTCGTAAGTTTATGCAAACTGG
ACAGGAGGGAGAGCAGAGGCAGAGATCACCGTGTCCACTCGACGTCCTGAGCGAAAAGCCACGTGTGCCC
ACGTGACGATGGAGACAGGAGGACCAGGGCTCTGCCTGCCCCCTTTTCTGAGCCCCTACTGCATTCAGCT
CTGGGGCCTGGGCCCTCGACGGCCACCACCTCCTCACCTGGGCTCCTGCGCAGCCAAGCGCAGTCCCGCA
CGCTCATCTTCCACGTCAGCTCCTGCAGCGAGAGCTTGGCATGCTTCCCCAGGGAGATGAACTTCTTGGT
GTTCCTGAGGAAGCGGCGTTCGTTGTGCCTGGAGCCCCAGAGGCCTGGGGGCACCAGCCGGCGCAGGCAG
GCCCGCACGAAGCCGTACACCTGCCAGGGGCTGCTGTGCTGGCGGAGCAGCTGCACCAGGCGACGGGGGT
CTGTGTCCTCCTCCTCGGGGGCCGCCACAGAGCCCTGGGGCTTCTCCCGGGCACAGACACCGGCTGCTGG
GGTGACCGCAGCTCGCAGCGGGCAGTGCGTCTTGAGGAGCACCCCGTAGGGGCACTGCGCGTGGTTCCCA
AGCAGCTCCAGAAACAGGGGCCGCATTTGCCAGTAGCGCTGGGGCAGGCGGGGCAACCTGCGGGGAGTCC
CTGGCATCCAGGGCCTGGAACCCAGAAAGATGGTCTCCACGAGCCTCCGAGCGCCAGTCAGGCTGGGCCT
CAGAGAGCTGAGTAGGAAGGAGGGCCGCAGCTGCTCCTTGTCGCCTGAGGAGTAGAGGAAGTGCTTGGTC
TCGGCGTACACCGGGGGACAAGGCGTGTCCCAGGGACGTGGTGGCCGCGATGTGGATGGGGGGCCCGCGT
GGTGCTGGCGGCCCACGGATGGGTGGGAGTGGCGCGTGCCAGAGAGCGCACCCTCCAAAGAGGTGGCTTC
TTCGGCGGGTCTGGCAGGTGACACCACACAGAAACCACGGTCACTCGGTCCACGCGTCCTGCCCGGGTGG
GCCCAGGACCCCTGCCCAACGGGCGTCCGCTCCGGCTCAGGGGCAGCGCCACGCCTGGGCCTCTTGGGCA
ACGGCAGACTTCGGCTGGCACTGCCCCCGCGCCTCCTCGCACCCGGGGCTGGCAGGCCCAGGGGGACCCC
GGCCTCCCTGACGCTATGGTTCCAGGCCCGTTCGCATCCCAGACGCCTTCGGGGTCCACTAGCGTGTGGC
GGGGGCCGGGCCTGAGTGGCAGCGCCGAGCTGGTACAGCGGCGGCCCGCACACCTGGTAGGCGCAGCTGG
GAGCCACCAGCACAAAGAGCGCGCAGCGTGCCAGCAGGTGAACCAGCACGTCGTCGCCCACGCGGCGCAG
CAGCAGCCCCCACGCCCCGCTCCCCCGCAGTGCGTCGGTCACCGTGTTGGGCAGGTAGCTGCGCACGCTG
GTGGTGAAGGCCTCGGGGGGGCCCCCGCGGGCCCCGTCCAGCAGCGCGAAGCCGAAGGCCAGCACGTTCT
TCGCGCCGCGCTCGCACAGCCTCTGCAGCACTCGGGCCACCAGCTCCTTCAGGCAGGACACCTGCGGGGG
AAGCGCCCTGAGTCGCCTGCGCTGCTCTCCGCATGTCGCTGGTTCCCCCCGGCCGCCCTCAACCCCAGCC
GGACGCCGACCCCGGGGAGGCCCACCTGGCGGAAGGAGGGGGCGGCGGGGGGCGGCCGTGCGTCCCAGGG
CACGCACACCAGGCACTGGGCCACCAGCGCGCGGAAAGCCGCCGGGTCCCCGCGCTGCACCAGCCGCCAG
CCCTGGGGCCCCAGGCGCCGCACGAACGTGGCCAGCGGCAGCACCTCGCGGTAGTGGCTGCGCAGCAGGG
AGCGCACGGCTCGGCAGCGGGGAGCGCGCGGCATCGCGGGGGTGGCCGGGGCCAGGGCTTCCCACGTGCG
CAGCAGGACGCAGCGCTGCCT

Protein Information

Protein Name

transcript variant 4

NCBI Protein GI

301129200

Protein Accession

NP_001180305

Protein pI

11.27

Protein Weight

112208.51

Protein Length

1069

Protein Note

Also known as TP2; TRT; EST2; TCS1; hEST2

Protein Sequence

>NP_001180305.1 telomerase reverse transcriptase isoform 2 [Homo sapiens]
MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPS
FRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLL
LRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREA
GVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAE
EATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSL
RPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRN
TKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSF
FYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGL
RPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQ
DPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFKAGRNMRRK
LFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLC
YSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLT
ALEAAANPALPSDFKTILD

Epitope Information

IEDB Linear Epitope