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CTLA4

General Information
Protegen ID 710
Sequence Strain (Species/Organism) Homo sapiens
Taxonomy ID 9606
Molecule Role Protective antigen
Molecule Role Annotation A clinical trial in patients who previously received autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GVAX; Cell Genesys, South San Francisco, CA, USA) with periodic infusions of CTLA-4 blocking antibodies was cobducted. This sequential treatment resulted in clinically significant anti-tumor immunity without grade 3 or 4 toxicity in most patients. Pathological analyses following treatment of pre-existing tumors revealed a linear correlation between tumor necrosis and the ratio of intra-tumoral CD8+ effector cells to FoxP3+ regulatory cells (T(regs)) (Hodi, 2010).
Related Vaccines(s) Allogeneic Large Multivalent Immunogen Breast Cancer Vaccine , ALVAC-hB7.1 , AML mRNA Positive Lysate Loaded Autologous Dendritic Cell Vaccine , Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine , Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine , GVAX Cancer Vaccine , GVAX Pancreatic Cancer Vaccine , ICT-121 Dendritic Cell Vaccine , Sargramostim Plasmid DNA Melanoma Vaccine Adjuvant
References
Hodi, 2010: Hodi FS. Overcoming immunological tolerance to melanoma: Targeting CTLA-4. Asia-Pacific journal of clinical oncology. 2010; 6 Suppl 1; S16-23. [PubMed: 20482528].
Gene Information
Gene Name CTLA4
NCBI Gene ID 1493
Genbank Accession AC010138
Chromosome No 2
Gene Starting Position 203867787
Gene Ending Position 203873959
DNA Sequence 
>NC_000002.12:203867787-203873959 Homo sapiens chromosome 2, GRCh38.p12 Primary Assembly
CCTTCTGTGTGTGCACATGTGTAATACATATCTGGGATCAAAGCTATCTATATAAAGTCCTTGATTCTGT
GTGGGTTCAAACACATTTCAAAGCTTCAGGATCCTGAAAGGTTTTGCTCTACTTCCTGAAGACCTGAACA
CCGCTCCCATAAAGCCATGGCTTGCCTTGGATTTCAGCGGCACAAGGCTCAGCTGAACCTGGCTACCAGG
ACCTGGCCCTGCACTCTCCTGTTTTTTCTTCTCTTCATCCCTGTCTTCTGCAAAGGTGAGTGAGACTTTT
GGAGCATGAAGATGGAGGAGGTGTTTCTCCTACCTGGGTTTCATTTGTTTCAGCAGTCAAAGGCAGTGAT
TTATAGCAAAGCCAGAAGTTAAAGGTAAAACTCCAATCTGGCTTGGCTGGCTCTGTATTCCAGGGCCAGC
AGGGAGCAGTTGGGCGGCAGCAAATAAGGCAAAGAGATAGCTCAGAACAGAGCGCCAGGTATTTAGTAGG
GGCTTCATGAATGCATGTGAGTTGGTTTAGTAGAGAGACACAGGCAATTTCAGACCCTTCTATGAGACTG
GAAGTGATTTAAGAGGGAAAGGATAGCCATAGTCCTGAATACATTTGAGCTGGGTTTCAGGATGAGCTCA
CAAGTTCCTTTAAAAAAAATTGACTTAAGCAAATCCTGGGAAGAGTTTTTTTGCTATACAATTCAAGGTT
TTAAGGTCCTCGGATTCATATACTTTATAAATGAATTAGCCAGCTTGTTTAAAATGTAGGGAAATTGTGG
GAAGAATGCCTTCTTTACTTAATTCAAGGTTTTAAGGTTCTCTTAATCAATTCTACTAGCTAATTAGCCA
ATTATTTAAAAATAAAAGTTTGAAATTGCCAAAAAAAAAAGACAAGGAAAAGGAAAGAAAGAAAGCCACC
AGTCTGTTTGGCATACAATACTTAATTGTTGCCTGACCTACGTGTGGGTTTCAGATGCAGATCCTCAGTT
TTCAGCTCTTCAGAGACTGACACCAGGTTTGTTACACGGCTTAAAATGATGAGTATATCCATTGAATCTC
AACCTTATCTCTCTCTAGACCTTCTTGGTTAAGAAACCATGTAGTTTGTATGAAGTAGGTACTCAAAAGA
TATTTGATGATTTAATTTTTACTGGAGAAGAAATATTCATATATGTTTTCTTATTTTTACATGTTTTAAA
TATGTAAAGATTAAATAAACACTCTTAGAAGTATTTAAATTTCCTAAAGTAAATTTATCTCAACCAGTAA
CAGGACCCTCCCAATACTGGAAAGTTGAGTGTGACCGCATTTAGTGGTGATGAGTGTGAGCTTGCTTGGG
GAGAGGGCAGGACATTTAGGATTTCTTAAGCTTAGAGTCAATACAATAAAGATTATTGAGTGCTCACTTG
GGTGGGCTATAATCACTGCTCACAGGAGTTCATGAACCACAAGTAAAAGAGTGAGGAGATATGATTAGCT
CACAAATAACTTTAATACAGAGCAGAAAGTAATGAACTACTGCAATGGAGTTATCACAGTGCTAAGGATG
CTCAGAGGGCATCTCTGATAGGCAGAGGTGAGGGTTAGGGAAGGAAGCTGTAGTCTAGCTAGCTAGAGCT
GCTGGAATAGACATGACAATGGCTGCTGCCAAACTGTTTTCTCTTCTGAGGACAGATGTCCCGTGCAAGT
GGCTTGGTGGAAGGGACTAGTGTCTCTAATATAGGGTGATTTATAAGCAGGAAAGTGTGTCCTAGAAATT
CAGACCAGAGTGATAGATTGGAATTGGATCATGGGGGACTCATTGAATGTTATTTATTGTATTTGTTTTT
GCGATCAGTGTTAGTAAAGTGTCAAAGGGATTGAGCAGATGAGTGACATCATGCAACACAAGTTTTGAGT
TTCACTTGTCAGACTGACTGGAGAGGGGCCTGGTTAGTTACAGGAAGGTAATTTGGCATGCAGCCACTAT
TTTTGAGTTGATGCAAGCCTCTCTGTATGGAGAGCTGGTCTCCTTTATCCTGTGGGAAAAGAGAACAAAG
GAGCATGGGAGTGTTCAAGGGAAGGAGAAATAAAGGGCAGAGAGGCAGCGGTGGTGTCAGGGGAAGCCCA
CAGGAGTTAACAGCAGGGTTGCCTCAACCTAGAGAGGAAGCGACCTGGTGCCCTCGGCTCTGTGGCTTCC
TTCATCTAACAACATCTTCCACTCTACAACAATGCCAGGGAAGGCGGAGGCTGGTACAGTGCATCAAGAC
ACAGCTACTCCTGGGTGACAGAGGTTCAGGGCCAGCTCACTAAGTAGGCAGAAGTTTTTGACATATACTT
TGAGAGATAAAGCAAGATTCTGTACCTCAACCTTCAGAATTTCCCCTACCACTCATTATAGTTCCGGAGC
TATATAGCTCCTATCATTCTATCATAACCTTAGAATACCAGAGAACATATCATCTCATCTAATTATCTCT
TACTATATGTGAAAAAAATGAAGGACATGGGGGAAGTGTGACTTGCCCCAAATCACATATTTCATGGTAG
AGCCAGGTCTTCTGTTTGTCATATCAGTGTTCTTCCTGCCACAACCATCTTGAAGAATCTATTTCTCAGT
AAGAAAATATCTTTATGGAGAGTAGCTGGAAAACAGTTGAGAGATGGAGGGGAGGCTGGGGGTGTGGAGA
GGGGAAGGGGTAAGTGATAGATTCGTTGAAGGGGGGAGAAAAGGCCGTGGGGATGAAGCTAGAAGGCAGA
AGGGCTTGCCTGGGCTTGGCCATGAAGGAGCATGAGTTCACTGAGTTCCCTTTGGCTTTTCCATGCTAGC
AATGCACGTGGCCCAGCCTGCTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTAT
GCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGACAGTGCTTCGGCAGGCTGACAGCCAGGTGACTGAAG
TCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGCACGGGCACCTC
CAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAG
GTGGAGCTCATGTACCCACCGCCATACTACCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGGTG
AGCAAAGCCATTTCACTGAGTTGACACCTGTTGCATTGCAGTCTTCTATGCACAAAAACAGTTTTGTTCC
TTAATTTCAGGAGGTTTACTTTTAGGACTGTGGACATTCTCTTTAAGAGTTCTGTACCACATGGTAGCCT
TGCTTATTGTGGGTGGCAACCTTAATAGCATTCTGACTGTAAAATAAAATGATTTGGGGAAGTTGGGGCT
CTCGCTCTGGAGTGCTAACCATCATGACGTTTGATCTGTACTTTTGATATGATATGATGCTCCTGGGGAA
GTAGTCCCAAATAGCCAAACCTATTGGTGGGCTACCCATGCAATTTAGGGGTGGACCTCAAGGCCTGGAA
GCTCTAATGTCCTTTTTTCACCAATGTTGGGGAGTAGAGCCCTAGAGTTTAAAACTGTCTCAGGGAGGCT
CTGCTTTGTTTTCTGTTGCAGATCCAGAACCGTGCCCAGATTCTGACTTCCTCCTCTGGATCCTTGCAGC
AGTTAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTGTTTCTTTGAGCAAAATGGTGAGTGTG
GTGCTGATGGTGCACCATGTCTGATGGGGATACCTTTAGTGGTATCAACTGGCCAAAAGATGATGTTGAG
TTTAGTGTTCTTGAGATGAGATGAGGCAATAAATGAAGAGGAAGGACAGTGGTAAAGAACGCACTAGAAC
CGTAGGCATTGGCATTTGAGGTTTCAGAATGACTAATATTTTAGATGAATTTGTTTGACATTGAATGTTC
ATGTGCTTCTGAGCAGGGTTTCAATTTGAGTAACCGTTGCAATAACATGGGGCAGCTGTTTTGCTCTTTG
TCTTCATGACAACTGTACTTAAGCTAACAGCCCTGAAACATGAGATTAGGCTGGGCAGAATGCTGCTAGA
GAGGACCACTTGGATGGTCTTTATTCTCCTTCTCCATGTCCCTCTCCATCACCTGGAAGTCACCTCTGGG
TGCCACTCTGGTGCCTTCCTTGTCGAAGCTGTAGCTGCTCACATGACACCTATCCCTGTTATCCAGTTTG
CTTGACTGGGACGTTTTGCCTTCCCCTTCAGCCAGGAAGTGAAAGTCCCAGTTTTTATTTATCACAGGTG
TTGGTATTGGTGGTAGAAGAGGTAGAATTATGGAATCAGGCCTCCTGTCAGGATTTCTTTTTGACAGTCC
CTCTCAGACACCTCTGCCTAAGGCCAGCTTTGCCATTACAAACTCTCCCTTCTCCCTCTCTCCCTTCTTC
TCTTCCTCTTCCTTCTTCTCGCTCTTTCTCTCTCTCTCTTTCTCCCTCTCTGTCTCTTATACACATACAC
AAAGATATACTCTATTCCAACATCCTCTACCCAACCTGACAGAGATGTCCTTTGCTGTAGGTTCAGCAGT
GGGGATGAGAAATACAGCTCTCAAACAGGATAACTAAAGCTTATTATCTTATCAAGCTTGTTCCCTTGCA
GACAAGATTGATCAATTATCATAGGCTTTCTGGGTGTTCTTTCTGAAGCTTTCTCAAAGTCTCTTTCTCC
TATCTTCCATTCAAGGCAAATGATTGCCATTTAACATCAAAATCACAGTTATTTATCTAAAATAAATTTT
AATAGCTGAATCAAGAAAATCTCCTGAGGTTTATAATTCTGTATGCTGTGAACATTCATTTTTAACCAGC
TAGGGACCCAATATGTGTTGAGTTCTATTATGGTTAGAAGTGGCTTCCGTATTCCTCAGTAGTAATTACT
GTTTCTTTTTGTGTTTGACAGCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCC
CAACAGAGCCAGAATGTGAAAAGCAATTTCAGCCTTATTTTATTCCCATCAATTGAGAAACCATTATGAA
GAAGAGAGTCCATATTTCAATTTCCAAGAGCTGAGGCAATTCTAACTTTTTTGCTATCCAGCTATTTTTA
TTTGTTTGTGCATTTGGGGGGAATTCATCTCTCTTTAATATAAAGTTGGATGCGGAACCCAAATTACGTG
TACTACAATTTAAAGCAAAGGAGTAGAAAGACAGAGCTGGGATGTTTCTGTCACATCAGCTCCACTTTCA
GTGAAAGCATCACTTGGGATTAATATGGGGATGCAGCATTATGATGTGGGTCAAGGAATTAAGTTAGGGA
ATGGCACAGCCCAAAGAAGGAAAAGGCAGGGAGCGAGGGAGAAGACTATATTGTACACACCTTATATTTA
CGTATGAGACGTTTATAGCCGAAATGATCTTTTCAAGTTAAATTTTATGCCTTTTATTTCTTAAACAAAT
GTATGATTACATCAAGGCTTCAAAAATACTCACATGGCTATGTTTTAGCCAGTGATGCTAAAGGTTGTAT
TGCATATATACATATATATATATATATATATATATATATATATATATATATATATATATATATATATTTT
AATTTGATAGTATTGTGCATAGAGCCACGTATGTTTTTGTGTATTTGTTAATGGTTTGAATATAAACACT
ATATGGCAGTGTCTTTCCACCTTGGGTCCCAGGGAAGTTTTGTGGAGGAGCTCAGGACACTAATACACCA
GGTAGAACACAAGGTCATTTGCTAACTAGCTTGGAAACTGGATGAGGTCATAGCAGTGCTTGATTGCGTG
GAATTGTGCTGAGTTGGTGTTGACATGTGCTTTGGGGCTTTTACACCAGTTCCTTTCAATGGTTTGCAAG
GAAGCCACAGCTGGTGGTATCTGAGTTGACTTGACAGAACACTGTCTTGAAGACAATGGCTTACTCCAGG
AGACCCACAGGTATGACCTTCTAGGAAGCTCCAGTTCGATGGGCCCAATTCTTACAAACATGTGGTTAAT
GCCATGGACAGAAGAAGGCAGCAGGTGGCAGAATGGGGTGCATGAAGGTTTCTGAAAATTAACACTGCTT
GTGTTTTTAACTCAATATTTTCCATGAAAATGCAACAACATGTATAATATTTTTAATTAAATAAAAATCT
GTGGTGGTCGTTT
Protein Information
Protein Name transcript variant 1
NCBI Protein GI 83700231
Protein Accession NP_001032720
3D structure: PDB ID 1AH1
Protein pI 8.56
Protein Weight 17855.22
Protein Length 174
Protein Note Also known as CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3
Protein Sequence 
>NP_001032720.1 cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM [Homo sapiens]
MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVR
VTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYY
LGIGNGTQIYVIAKEKKPSYNRGLCENAPNRARM
Epitope Information
IEDB Linear Epitope