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SLC5A5

General Information
Protegen ID 716
Sequence Strain (Species/Organism) Homo sapiens
Taxonomy ID 9606
Molecule Role Protective antigen
Molecule Role Annotation The aim of this study is to determine the feasibility of utilizing the hNIS antigenic protein in enhanced-antigen-associated immunotherapy using image analysis with a gamma counter. To accomplish this, minimalistic immunogenically defined gene expression (MIDGE), either plain or coupled to a nuclear localization signal (NLS) peptide, was used as a vector system. Vaccination with MIDGE/hNIS, MIDGE/hNIS-NLS and pcDNA3.1/hNIS produced a significant increase in the number of hNIS-associated IFN-gamma-secreting CD8(+) T cells, with MIDGE/hNIS having the strongest effect. In addition, immunization with the hNIS encoding vectors induced antigen-mediated antitumor activity against NIS-expressing CT26 tumors in vivo, with the highest tumor free rate (100%) and lowest tumor growth being observed up to 40 days after the CT26/NIS tumor challenge with MIDGE/hNIS than those resulting from other immunization groups (Choi et al., 2007).
Related Vaccines(s) Cancer DNA Vaccine MIDGE/hNIS encoding hNIS protein
References
Choi et al., 2007: Choi Y, Jeon YH, Kang JH, Chung JK, Schmidt M, Kim AC. MIDGE/hNIS vaccination generates antigen-associated CD8+IFN-gamma+ T cells and enhances protective antitumor immunity. International journal of cancer. Journal international du cancer. 2007; 120(9); 1942-1950. [PubMed: 17266027].
Gene Information
Gene Name SLC5A5
NCBI Gene ID 6528
Genbank Accession AB032811
Chromosome No 19
Gene Starting Position 17871393
Gene Ending Position 17895174
DNA Sequence 
>NC_000019.10:17871393-17895174 Homo sapiens chromosome 19, GRCh38.p12 Primary Assembly
CCCACTCAGAACTTGAGCTCTGAATGTCTCCCACCCAGCTTAGCCCAAGAGCGGGGTTCAGTGATGCCCA
CCCCCTAAGGCTCTAGAGAAAGGGGGTAGGCCCACATGCCAGTTTGGGGGTGGTAAAGCCAGGTAAGTTT
TCTTTATGGGTCCCCTGAAACCCTGAAAGTGAACCCCAGTCCTGCATGAAAGTGAGCTCCCCATAGCTCA
AGGTATTCAAGCACAATACGGCTTTGAGTGCTGAAGCAGGCTGTGCAGGCTTGGATAGTGACATGCCCTC
TCTGAGCCTCAATTTCCCCACCTGTCAACAGCAGACAGTGACAGCTGTGATCAGGGGATCACAGTGCATG
GGGATGGGTGGGTGCATGGGGATGGAGGGGCATTTGGGAGCCCTCCCCGATACCACCCCCTGCAGCCACC
CAGATAGCCTGTCCTGGCCTGTCTGTCCCAGTCCAGGGCTGAAAGGGTGCGGGTCCTGCCCGCCCCTAGG
TCTGGAGGCGGAGTCGCGGTGACCCGGGAGCCCAATAAATCTGCAACCCACAATCACGAGCTGCTCCCGT
AAGCCCCAAGGCGACCTCCAGCTGTCAGCGCTGAGCACAGCGCCCAGGGAGAGGGACAGACAGCCGGCTG
CATGGGACAGCGGAACCCAGAGTGAGAGGGGAGGTGGCAGGACAGACAGACAGCAGGGGCGGACGCAGAG
ACAGACAGCGGGGACAGGGAGGCCGACACGGACATCGACAGCCCATAGATTCCTAACCCAGGGAGCCCCG
GCCCCTCTCGCCGCTTCCCACCCCAGACGGAGCGGGGACAGGCTGCCGAGCATCCTCCCACCCGCCCTCC
CCGTCCTGCCTCCTCGGCCCCTGCCAGCTTCCCCCGCTTGAGCACGCAGGGCGTCCGAGGACGCGCTGGG
CCTCCGCACCCGCCCTCATGGAGGCCGTGGAGACCGGGGAACGGCCCACCTTCGGAGCCTGGGACTACGG
GGTCTTTGCCCTCATGCTCCTGGTGTCCACTGGCATCGGGCTGTGGGTCGGGCTGGCTCGGGGCGGGCAG
CGCAGCGCTGAGGACTTCTTCACCGGGGGCCGGCGCCTGGCGGCCCTGCCCGTGGGCCTGTCGCTGTCTG
CCAGCTTCATGTCGGCCGTGCAGGTGCTGGGCGTGCCGTCGGAGGCCTATCGCTATGGCCTCAAGTTCCT
CTGGATGTGCCTGGGCCAGCTTCTGAACTCGGTCCTCACCGCCCTGCTCTTCATGCCCGTCTTCTACCGC
CTGGGCCTCACCAGCACCTACGAGGTACCGGACAGAGGCCCGGGGGTAGGACCTGCCCCACTGGCAGTGC
TGGGACCCCGTGTGGGGGAGGCGCTGGGGCTTTGGGCCGCTGTACAGGAGGACGCGGATGGCACCTCGGT
GCTTTAACGGAAGGGGCCCCTAGGCAGACACGTGGGGAGGGTTCTAGGAAGAGGCCCCAGGCGCCCGGCG
AGGGGCAGGAAGGAGGAAGAGAGAGCCTGGCGTCCTGCTCCTTCGGTGGAAGCGCGCGCGGGGCGGGGCC
CGGCTCGACCAGGTGTGTCCTCACGGGTGGACACACACCTGCCCCCCACCTGCCCGGGCGTGCAGACCCA
CGTGTGCGCGCTAGAGGGGACTGCTGACGGCTCCGGGGTTCGAAACCTGGCTTCACTGCTTTCTTGTATC
TTGGGCAAGGGGCGTGCCTCTCTGTTTGGGTTTCCCAGCTGTCCAATGGGCGAATTACAGGACCTCCCTC
CAGGGGAGAGGGTAAAGCGATTAAAATCGTGACCGGGGCCCGGTGCGGTGGCTCACGCCTGTAATCCCAG
CACTTTGGGAGGCCAAAGCATGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCG
AAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGATGTGGTGGTGGGCACCTGTAATCCCAGCTACT
TGGGAGGCTAAGACAGGAGAATTGCTTGAACCCGGGAGGTTGCAGTGAGCCGATATCGCGTCACTGCACT
CCAGCCTGGGCGACAGAGCGAGACTCTTGTCTCAAAGGAAAAAAAAATATTGTGGCAGGGCGCAGTGGCT
CACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGC
CTGGCTAACATGGTGAAACCCCGTCTTTACTAAAAATACAAAAATTAGCCGGGCATGGTCGCGCGCGCCT
GTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAG
CCGAGATCGTGCCAGTGCACCCTAGCCTGGGCGACAGAGCGAGACTCCGTCCCCCCTCCCCCCCAAAAAA
ATCGTGACAGGTATATCCTAGGCGGCCAACACCATTGGCCCGGGGCACTGTCTACACTGTGCGCTTGCGG
GCCACGTCGGTGTCTGCTGAGCGGTGGCTGCTCCAGGAGCCCGCGCCCGTCAGGCGCAAGTGGGAGGGCG
CGTGCACACGCATGGACCAGTCCTCCAGGTCCACGGGGTACGCACAGGCACGGGATGGCACCTGTGCACG
GGTGTGTGCGTGCGGCGGGGCCCCCACGTGCAAGAATCTGGCGGGCGCGGTTGGCTTCCGGAGGGAGGGG
CCCACCTAGAGAGCAGACCAGGGACCCGAGAGGCCTCGGCTCCTGGGTAAGGACTGTCCAGGTGACCTCG
AGTCCCTCCTTGCAGTACCTGGAGATGCGCTTCAGCCGCGCAGTGCGGCTCTGCGGGACTTTGCAGTACA
TTGTAGCCACGGTGAGTGGCCTCGGCCCCGCCCTCCGCTCAGGGCCCCGAGAGCGTCAGCCTTCACTAGC
CCGGCCCCCACCATTCAAGACCCCGCCCAGACCCCGCCCCCCATGCTCCCGTTCTGACCCCGCCCCCATC
AGTCCCCTCCCACACCACAGCCGGCCTGACCCCGCCTGCACTCTGGAAGACCCGGCCTATCTGCCCCGCC
CATATTCTGGGACCACCCTTCTGCCTCCTCTCCCCATCCCCAACTCGCCCAGACGCCCTCCCTGCTCACC
CGCCCCACACTCTGTCTACAGATGCTGTACACCGGCATCGTAATCTACGCACCGGCCCTCATCCTGAACC
AAGGTGTGACTCTGGGAGATTAGGGAAGCATGTCTGGGAAGAGAAAGGGAGGGAGAGGAGAACCCAAGAC
TAAGTTTGCGCCCCGCCCAGGGGCCTAACAGGGGGACCTCTTTTTGCATAGTGACCGGGCTGGACATCTG
GGCGTCGCTCCTGTCCACCGGAATTATCTGCACCTTCTACACGGCTGTGGTGAGTGGCCCTGGGAACTCA
CTCCATACGGGGGATCGGGCCCACTGTGTCTCTTGTGGGGAGACTCTGGGCTTGCCCCTTTCTCCTGAGG
AAGCCTCTGTCCCAGCTGGGACCCAGTGTCCTCATCTTTATAGTGAAAAATGATCTGAAAAGCTTATTGC
TGAGAATCTAGAGGTATGGTAGCTTCAGGCATGGCTGGATCCAGGCTTCCACCTCTTCTGGCTTCCAGTC
CAGCAGGAAGTGAGCTCCTGCTTCATCCTGGGGCTGGCTGAGGTCCCAGGGAGGGCTACCTTTGGCTGGC
TCAGGTCTGACCTTGATGGCGATATTATCATCGTAGTGATAATAATAGTAATGGCGGCCGGGCGCGGTGG
CTCACGTCTGTAATCCCAGCACTTTGGGAAGCAGAGGCAGGCGGATCACCTAAGGTCAGGAGTTCGAGAC
CAGCCTGGCCAACATGATGAAACCCCGTCTCTACTAAGAATACAAAAATTACCTGGGCGCAGTGGCACGC
GCCTGTAATCCTAGCCTCTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCGG
TGCGTGGAGATTGCGCCATTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAATATAAT
AATAATAATAATAATAGTAATGGCAGCAATCACTCACTGACACTCGTATATGTCAAGTCATATTCCAAAT
CTTTTTCACTTATTAACTTGTTTAATTCTACTGGGCACAGTGGCTCATACCTGTAATCCCAGCACTTTGA
GAGGCCAAGGTAGGAGGATCACTTGAGGCCAGGGGTTCGAGACCAGCCTAGGCAACATAGTGAGACCCCC
CCCCGCCCCCATCTCTACAAAAAAAATTTTTTTTAAATTAGTCGGGCATGGTGGCACCTGCTGTAGCTCC
AGCTACTCCGGAGGCTGAGGCAGGAGGATCACTTGAGCCTAAGAGTTCCAGTCTGCAGTGAGCTGTGATC
ACACCACTGCACTCCAGCCTGGGCAAAAGACAGAAACCTTTTCTTTAAAAATAAAATAACTAACTTAATT
CTTACAACAACACAGTAAGAAGGTATTATTATTAATCCCACTTTAGAGAGGAGGAGACTGAGGCATAGAA
GGGCATCAGTCCTAGGCACCACTGAAGGCCAGGTCCCCCATCTAACCGCCCCTCTCCCTCTCTCTGTCCC
ATGCTGCAGGGCGGCATGAAGGCTGTGGTCTGGACTGATGTGTTCCAGGTCGTGGTGATGCTAAGTGGCT
TCTGGGTTGTCCTGGCACGCGGTGTCATGCTTGTGGGCGGGCCCCGCCAGGTGCTCACGCTGGCCCAGAA
CCACTCCCGGATCAACCTCATGGAGTGAGTGAAAATGCAGAGGATACTCCAGCAGGATGGGGCTGGGACC
AGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGCTCAGG
AGTTCAAGACCAGCCTGGGCAACATGGTGAAAACCCATCTCTACAAAAATACAAAAATTAGCTGGGCGTG
GTGGTGCACCTGTGGTCCCAGGTAGTTGAGAGGCTGAGGCTGGAGGATTGCTTGAGCCCGGTAGGTGGAG
GCTGCAGCAAGCTGAGATCACACTACTGCACTCCAGCCTGGATGACAGAGCTAGACCCTGTCTCAAAAAA
AAAAAAAAAAAGAGGCTGGGTGCAGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGG
GGATCACCTGAGGTCAGGAATTTGAGACCAGCATGACCGACATCGAGAAACCCCATCTCTACTAAAAAAT
ACAAAATTAGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGATGGCAGAT
CATGAGGTCAAGAGATTGAGACCATCCTGGCCAACTTGATGAAAGTCCGTCTTTACTAAAAATACAAAAA
TTAGCTGGGCATGCTGGCAGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA
ACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATGGCATCACTGCACTCCCGCCTGGTGACAGAGAGAGAC
TCCGTCCCCCCCCTAAAAAAAAAAAAAATTAGCAGGGCGTGGTGGCGCATGCCTGTAATTCCAGCTACTC
GGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCGGTGAGCCGAGATCACACCAT
TGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTTTAAAAAAAAAAAAAGAGGATGGGGCTGGGCT
CCCTTTGTGCCGTGGGATGGTAGAAATCAGCCAATGCCTCCTGCTCCAGGAGGCCCTCGCTGCTCTCTTC
TCCTCCCCTCAGACCAGATTGGGGGCTAAAGCCTCTCTGAACTCTCAGCTGGGCAAAGAAAGGTTTTTAA
GTGCGTGGATAGATGATTCAGTAAACAAATACGTGAATTTTCAATCTGGCAAATGCCTATGCATATGTCA
AACCCACTCCATTTATTATTTATTTATTTTTAATTTAATTAATTTTTTTTTTTTTGAGATGGAGTCTCGC
TCTGTCACCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTGAAGT
GATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAGAGGCACCCGCCATTATTCCCAGCTAATTTTTG
TATTTTTATAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGCCTTGAACTGTGACCTCAGGTGATCCAT
CCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCTGGCCAACAAAACCCACTCC
AAATGTCCCCTATAAGGTCCAGAAGCGCTGTCTGGGGCCCTTGGGAGGGTGAAGTCAGCGTGACATCTCC
ACGTGGCTAACTTGCCCTGTCCCCACCCAGCTTTAACCCTGACCCGAGGAGCCGCTATACATTCTGGACT
TTTGTGGTGGGTGGCACGTTGGTGTGGCTCTCCATGTATGGCGTGAACCAGGCGCAGGTGCAGCGCTACG
TGGCTTGCCGCACAGAGAAGCAGGCCAAGCTGTGAGTGTTTCGGGGAGCAAGGTCGGGGTTTCTGGGACA
TGCTGCCCCCCTCCACCAGCCTGAGGCTATCCCCTAAGCCTGAGGCTGCCTCTTCCCCCAGGGCCCTGCT
CATCAACCAGGTCGGCCTGTTCCTGATCGTGTCCAGCGCTGCCTGCTGTGGCATCGTCATGTTTGTGTTC
TACACTGACTGCGACCCTCTCCTCCTGGGGCGCATCTCTGCCCCAGACCAGGTGAGTCCCACCCAGGCTC
CTGGTTGGCTCTGCACTCCCTCACTAGCTTGGTGGGATTGAGGTCGAAGAGCATTCCTAGCAGAGGGAAT
GGCCTGTGCAAAGGCCAAGAAGTAGGAAAGAGCTGAGAGGAGGCCAGGTGCGGCGGCTCATGCCTGTATC
CCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGTCTGGCTAACAT
GGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCTGGACGTGGTGGCACGCACCTGTAGTCCCGGC
TACTCAGGAGGCTGAGGCAGGAGAATCTCTTGAACCCGGGAGGCGGAGGTTGCGATGAAGGGAGATCGCA
CCACTACACTCCACCTTGGATGACAGAGTGAGACTCTGTCTCAAAAAAATAAAATAAAATAAAATAAAGA
GTTCAGAGGAGGATCTGCAAGGAATGGGAAAGGTGAGTCTGGGAGGCAATGGACCGCCCTCAGTAGGTGT
GAGCAGACAAGGGCCACATTCAGATCTAGAGTTCCAGAGAGTTCCAAAGATCCCCTGGGAGATGCTCAGG
AGGAGATGAAACCATGACCCAGGCCGGGCATGTTGGCTCACGCCTGTAATCCCAGCACTTTTGGAGGCCG
AGACAGGCAGATCACTTGAGGTTAGAAGTTCGAAACCAACCTGGCCAACATGGTGAAACCCCCCTCCACT
AAAAATACAAAAATTACCTAGGCCTGGTGATGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAG
GAGAATAGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCAGAGATCGCGCCATTGCACTCCAGCCTGGG
TGACAGAGAGAGACTCCATCTCAAAAAAAAAAAAAACAAAAAAAAAAAACCAAAACAAGGCTGGGCGCGG
TGGCTTACGCCTATAATCTCAGCACTTTTGGAGGCTGAGGCAGGGGTATCACCTGAGGTCATGAGTTGAA
GACCATCCTGACCAACATGGAAAAACCCCGTCCCTACTGAAAAATACAAAATTAGCCGGGTGTGGTGGTG
CATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATAGCTTAAACCTGGGAGGCGGAGGTTG
CGGTGAGCTGAGATGGCGCCATTGCACTCCAGCCTGGGCAACAAGAGAGAAACTCCGTCTCAAACAAAAA
TAAAAACAAAACAAAACAAACCCACAAAAACAAAAACAAAAACTGTAATCCAGCGGGAACTAATCATGTT
GGTGATAATAATAATGACAGCTCTGGTCTCCCATGTCCCAAGCGTCCACTCTGTGCCTCATGCTGTTCCC
TTCACCAGCAGTTAGTTCTCCATCTAATCTTTCTTCTGAGAAAGGCAGGGCAGTCACGGCTCCAACTTTA
CAGATGAGGAAATTGAGGCTCGGGGGGAAGTCACTGCCTGAGGTCAATGGGCAAGTCGGGGGGCGGTGCC
AGGACCCATGCCTAGGTCACACCCCAAGTAGAGTTCTGACCATGGGGTTCAGAGTTAGCAGAGGGTACGG
GGGACCACCCCATCTGCAGTCCTCCCTGGAGGTCAGATCCGGGACTGCTGGACTGTGTAACTTCAGGGAG
GGACTGTACTCTCTGCCTCACAGTCTTCATCAATAAAATGAGGATGACACGGGTCCCTGCTTCACAGGGA
TCCCAGGGCTCAGAACACAGTGGGGCTCAGGGACAATTCTCAGGTTCATGCAGTTGATCAACAAATGCAC
ATTATAGCCTGAGGAACATAGGGAGACCCCATCTTTACACAATTTTTTTTTTTTTGAGCCAGAGTCTCAC
TCTGTTGCCCAGGCTGGAGTGCAGTGGCGCAACCTCAGCTCACTGCAACCTCTGGCTCCCAGGATCAAGC
CATTCTCTTGCCTCAGCCCCCGAGTAGCTGGGATGACAGGCATGCGCCACCATGCCCAGCTAATTTTTTT
GTATTTTTTGTAGGGGTGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATC
CACCTGCCTCAGCCTCTGAATGTGCTGGGATTACAGGCATGAGCCACTGTGCCCGGCCTTTCTTTCTTTT
CTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTGGCTCTGTTGTGCAGGCTGGAGTGCAACGGCGCGATCT
CCGCTCGCTGCAACCTCTACCTCTCAGATTCAGGCAATTCCTCTGCCTCAGCCTCCCAAGTAGCTGGGAC
TCCAGGTGCCAACCACCACACCCAGCTAATTTATGTATTTTGGGTAGAGATGAGGTTTCACCATGTTGGC
CAGGCTGGTCTTGAACTTCTGAGCTCAAGTGATCCACCCGCCTCGGCCTCCCGAAGTGTTGGGATTACAC
GCGTGAGTCACCCTGCCCGGCCAGACCCCTATCTTTACACAAAAATTTAAAAAAATTAGCCAGGCATGGT
GGCGCACACCTGTGGTCTCAGCTACTGGGGGACTGAAGCAGGAAGATCGCTTGAGCCCAGGAGTTCTAGG
CTGCAGTGAGCCACATTCATGGGACTGCACTCCCGCCTGGGCAACAGAGCAAGATCTTTTCTCAAAACAA
AACAAAACAAAACAAAACCACAGACAAAAACTAAATGCATATTAAATGCCGACTCTGAGCCCTGTCCGTC
TTGGGTGCTGGGGACGTGCAGCATCAGGACAGATAGATGCCCCGGTCCTCGGGGTGCAGCTGTCTGGGAG
GCTGACCCCCAGTTCTCCCCAGTACATGCCTCTGCTGGTGCTGGACATCTTCGAAGATCTGCCTGGAGTC
CCCGGGCTTTTCCTGGCCTGTGCTTACAGTGGCACCCTCAGGTGAGCACCCCTGCTTGTTCATGGAGCAT
TATTTCAGCCCCTGGGAGCCTCCTTATCCTGGCCTGCCATCCCTCTGGGGCATGGAATGTTCTGGACCTG
TCCATCAGTCCCAGTTCCTGCTTGATCCCTAGAAGACAGCTCAGGTAGGCGCTGGCAGAGAGCATGCCCT
GGGCACAGGGACCCCAACTGCAAGGGTTTACCTTCTTATCACCTGTCAGGGCCACGCCTGACTCTCCTCT
CTTCTTCTTCCTTCTTTCCTTCCTTCCTCCCCAGACAAATATTTGTTGAACATCTACTATGTGGCAGGTA
CTGTTTTTTTTTGTTTTTTTTCCGGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCCAT
CTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGG
ATTACAGGTCCACGCCACCACAGCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTG
GCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCATGCTTTGGCCTCGCAAAGTGCTGAGATTGC
AGGCATGAGCCAACGTGCTCAGCCCAGGTACTGTTGTTCTAAACCCTGGGGCACAGCCATGACCAAGCAG
TCCCCTGCTTCTGCCTTCCAAGGCCACACACTCAGGTGGTTTCCACTCTTCCGGGACTTCTGGTCACATG
CCCTCACTGTCCCTTTTGCAAATCTCCCACATGTGACTGCAGTCCCTCTGGAACCAGAACCCACCTGTCT
GTCCCACCTGCCCTTGGTCACAGGTGTCCTTGCTCCTGTAGGGATGTCTCAGGTCTTCGGGGAGGGGAGG
GGCAAATATCTCCTTCACCTTTGCAGGACTGGGTTACCCCCACCGTTGCCCTCAGGCTGGGTGAGGTCTG
GCAGGCCAGATGGTGTGGACGGTCTCTCCATATGGCCTGAGGACCCCCCGCTGCCTTCCTCACACAGCAC
AGCATCCACCAGCATCAATGCTATGGCTGCAGTCACTGTAGAAGACCTCATCAAACCTCGGCTGCGGAGC
CTGGCACCCAGGAAACTCGTGATTATCTCCAAGGGGCTCTGTGAGTTTCAGGGAGACCTGGGTGGGAGGC
CAGGGCAGTCCCTCCCCGTTGACCGTGCCATCCTCATCCACTACAGCACTCATCTACGGATCGGCCTGTC
TCACCGTGGCAGCCCTGTCCTCACTGCTCGGAGGAGGTGTCCTTCAGGTGAGACCCCACCTGCCCCCTGC
CCTGGTCTCCTGAGAGGTGGGGGCACCTTTCCCTCTTTCCCATTAAACTGAGGCTCAGAGAGGTCACATG
TGTCAGTGGCAGAACTCACTTCTATGTTTTTTTTTTTTTTGAGATGGGGTCTCACTGTGTTGTCCCAGGT
TGGTGAGCAGAGGCCCGATCATAGCTCACTGCAACCTCCAGCTCCTGGGTTCAAGCCATCCTTCCACCTC
AATCTCCCAAGTAGCTGGAGTTACAGGTGTGTGCCACCATGCCTGGCTAATTTTTTTCTTTTTTCTTTTT
TTTTTTTTTTTGAGGTGGAGTGTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCGCT
GCAACCTCCACCCCCTGGGTTCAAGGAATTCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGTGCATG
CCACCATGCCCGTCTAATATTTTTGTATTTTTTTTTCTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTG
GAGTGCAGTGGCACCATCTTGGCTCACTGCAAGCTCAGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAG
CCTCCCGAGTAGCTGGGACTACAAGCGCCCGCCACCACGCCTGACTAATTTTTTGTATTTTTAGTAGAGA
TGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCTCCTCGGCCTCCC
AAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCTTATATTTTTGTATTTTTATTAGAGATGGGA
CTTCACCATGTTGGCCAGTCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTCTGCCTCCCAAA
GTGTTGGGATTACAGGTGTGAGCCACCACGCCTGGCCTGGCTAATTTTAAAACTTGTTTTTAGAGACAGG
GTCTCGCTTCGTGCCTAGGCTTGTCTTGAACTCCTGGCCTCAAGCAACCACCCGCCTCAGCCTTCCAAGT
CGCTGAGATTAAGAACTAAGTTCTATTTGATGCCAGAGGCCATCAGGGGACTTTTTTGCAGCTGGCTGGC
TTGGGGTGGGGGAATTGGGAAGGGGGAGGTGGCGACAGAAAGGGCCTCCCTATGGAGGTTGCAGTGAGCC
AAGATCGCGCCACTGCACTCCAACCTGGACAGCAAAGTGAGACTCTGTCTAAAAAAAAAAAAGAAGAAGA
AAGGGTCTCCCTGGCTTGAGGGTGGGACTGCCACCCCCAAGAGATAATCAGTGTCTTTGCCTCCAACCCA
AGGGAGATAGGCAGGAACAAGGGGGGGGGGTCCTCTCCCCTTTAGGGAAACTGAGACACAGAGGAGTCCT
TGAGACCCACATTGGAGTTCCTGAGGTCTCGCTTTCCCAGCGGGTAAACTGAGGCCCAGAGCGGTGGGAG
GGCTCCGCCCTCAGCCCCACTTCCACCTACTCTCCCAGGGCTCCTTCACCGTCATGGGAGTCATCAGCGG
CCCCCTGCTGGGAGCCTTCATCTTGGGAATGTTCCTGCCGGCCTGCAACACACCGGTGAGTGGGGGCGGG
GCAAGGGGCGGGGAGGGGCGGGGCCGGACAGGCCCCTCCCCTTCCCTGACGCCGGCTCTGCCCCCAGGGC
GTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCAC
CCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTC
TGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGGTGAGCAGACTTGAGG
GTAGGGGGGTACCCGAGCCCTGGATGGTGTGATCTTGAAGGGAAACTTACTTGCCCTGCACTCTGTGTAA
GAAGCCTGATTAGTAAAATGCATTCCTGGGGGAGGGAACGGTAGGTGCAAAGGCCCTGAGGCCACAATCG
GGTTAGTCCCAGTCCAACTGCACTGAGGTTAGGGTGCATTTAATGGGAGGAGAGATGGGTGGGAGATATG
GTGCAGCCAGAGGAAGCTAGTACTTTTTTTGTTTTGTTTTTCTGAGACAGAGCCTCGCTCTGTGGTCCAG
GCTGGAATGCAGGGGTGCAATCTCAGCTTACTGCAGCTTCAACCTCTCAGGCTCAAGCAATCCTCCCAGC
TTGAGGGAGGCCCAGAATTTGGTTTGGTTCTATTTTTTATTGAGATAAATTAGCCATTTAAAAGTGGCAT
TTAGGCCAGGCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCA
CCTGAGGTCAGGAGTTCAAGACCAGCTTGATCAACATGGGGAAACCCCCGTCTCTACTAAAAATACAAAA
CTTAGCCAAGCGTGGTGGCAGGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCGCTTG
AACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCACCACTGTATTCCAGCCTGGGCAACAAAAATGA
AACTCCAACTCAAATAAATAAATTAAAGTGGCATTTAGTATATTTGTGCAACCATCACCACTATCTAAGT
CAAGAACGTTTCCTCTTTTTTTTTTCTAATTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGCC
AGGCTGATCTTGAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAATGCTGGGATTACAGG
TGTGAGCCACTGTGCCTGGCCCCAAAAACATTTTCTATTTTTTTTTTTTTTTGGAGCAGGGTCTTGCTCT
GTTGCCCAGGCTGGAGTCCAGTGGCACGATCATAGCTCACTGCTGCCTCAACCTCCTGGGCTCAAGGAAT
CTTCCTACCTCAGCCCCCCTAGTTGCTGGGACCACAGGTGCACACCATCATGTCCTGCTTGTTTTTATTT
TTATTTTTTGTAGAGACAGGGTCTGGCTATGTTGCCCAGGCTGGTCTGGAATTCCTGGGCTCAAGCGATC
TGCCCACCTCAGCCTTGCAAAGTGCCAGGATGACAGGTGTGGGCACCCAGCCAACCAAGAACATTTTCTG
TTTTGTTTATTTATTTATTTATTTATTTTGGTTTTTTGGGTGGGTTTTTTTGCTTTTTGTTTATTTGATT
TTTTGGAGACAGGGTCTCACTCTAACACCCAGGCTGGAGTGCAATGGCACAATCACAGCTCACTGCACCA
TTGACCTCCAGACTCCGATGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGTATCAC
CATGCTGGGCTAAATTTTTTGTATTTTTTATAGAGACGAGTTTTTGCCATGTTGCCCAGGCTGGTCTCAA
AGTATTGGGCTCAAGTGATCTGCCTGCCTCTGACTCCCAAAGTGCTGGGATTACAGGTGTGAGGCACTGT
TCCTGGTCATAAGAACATTTTTATCACCCCAGAAAGAAGCCCTGTCCCCATCAGCAGTCACTTCCCACTT
CCCCCTCTCCCCAGCTCCTGGCAAGCACGAATCCACTTTCTGTTTCTATGAATTTGCCTGTTCTGGGCAT
TTCATGTAAATGGAATCATAAAATATGTGATCTTTTGTGTCTTAGCATAATACATATATATTTTTTGAGA
CGGGGTTTCACTTTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCCCAGCTCACTGCAACCTCTGCCTCC
CAGGTTCAAGCAATTCTCCTGTCTCGGCCTCCTGAGTAGCTGGGGTCACAGGCATATGCCACCACGCTTG
GGTAATTTTTGTATTTTTAGTAAAGATGGGGTTTCACCATATTGATCAGGCTGGTCTTGAACTCCTGACC
TCAGGAGATCCACACATCTTGGCCTTTCAAAGTACTGGGATTACAGCAGAGTACAGTGGAGCCACTGCAC
TCCAGTCTGGGTAACAGAGTGAGACTCCACCAAAAACAAACAAAACCAAAAACATTTGTGAACAAGTTTT
GGTATGGACATATGTTTTAATTTCTCTAGGTATATACCTATGAGTGGAATTGCTGGATCATATGGTAATT
CTTTAACTTTTTTTTTTTTTTTTTAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGA
TCTCCACTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCCGCTTCAGCCTCCCGAGTAGCTGG
GACTACAGGCATATGCCACCACGCCTGGCTAATTTTTATATTTTTAGTAGAGAAGGGGTTTCACCATGTT
GGTCAGGGTGGTCTCAAACCCCTGACCTCAGATGATCCGCCTGCCTTGGCCTCCCAGGGTGTTAGGATTA
CAGGCCTGAGCCACCACGCCCGGCCTATGTTTAACTTTTTGAGGAACTACCAGACTGTTTTCCACAGCGG
CCACATCATTTTACATTCCGACCAGCAACATATGAGGATTCTAACTTCTCCACGTCCTCGCCAATACTCA
TTATTCTCCATCCTAGTGGGTGTGAAGTGATACCTCACTGTGGTTTTGATTTGCATTTCCCTGATGAATA
ATGATGTTGAGCATCTTTCTTTTCATTGGCCATTTGTGCATCTTCTTTGGAGAAATGTCTATTCAAACCC
TTTGCCCATCCAGCCTGGGTAACATAGAAAGACCCTATCTCTATAAAAATAAAAATGAAAAAATTAGCTG
GGCATGGTGGTGCACACTTGTAGTCCCAGCTCCTTGGGAGGCTGAGGCAAAGAGGATCGCTTGAGCCTGG
GGGGCCAAGGCTGCAGTGAAGCATGATCCCACCACTGCACTCCATCCTAGGCAACAGAGCAAGACCCTGC
CTCAAATTAAAAAACAAACAAACAAAAAAACACCCTTTGCCCATTTTTAAATTGGGTGATTTGTCTTTTT
ATTGTTGAGTTATAATTTACATATTTTTATATCTTTATGTATTCTGGGTACAAGCCCCTGATCAGATGTA
TAATTTGCATGTGATATTTTCTCCCATTCTGTAGGTTGTCTTCATTCTCTCGATAGAATCCTTTGATGCA
CAGAAGTTTTTAATTCTTTTTTTTGGTGGGCGGATGGAGTCTAACTCTGTCACCCAGGCTGGAGTGCAGT
GGTGCGATTTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGGGATTCTCCCACCTCAGCCTCGTGAG
TAGCTGTGACTACAGGTGCACACCACTATGCCAGGCTAATTTTTATATTTTTAGTAGAGATGGGGTTTCA
CCATGTTAGCCAGCCTGGTTTCAACTCCTGACCTCAGCCTGCCTCAGCCTCCCAAAGTGCTAGGATTACA
GGCATGAGCCAACATGCCTGGCCAGAAGTTTTTAATTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTC
TGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCATGCCA
TTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGACTACTGGCACCCGCCATCAGGCCTGGCTAATTTTTTAT
TATTTTTTTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCG
TGATCCACCCGCCTTGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACCACGCCCAGCCAGTTTTT
AATTTTTGATGAAGTCCAATTGATTTATTTTTTTCTTTGGTGGCTTTTGCTTTTGGCGTCATATCTAAGA
AACAATTGCAGTCACGAAGATTCCCACCTATGTTTTCTTCTGAGAGTTTAATTTGGTTTGATTTTGAGGG
TGACAGGGAGCCACAGAGGGTGACGGGCAGCAGCAGGTGATCTGAGTTACATTTTAGTAATGTGCCCTTT
GGCTGTGTGTGGAGGACGTCTAGGGTGGGGATGGGATACCTGGAGGGAAGGAACATTGGCTACTGCACAG
ATCTGGGCAGACAGTAATGGAGGTCTGTGCTAGGCCATGGCAGTTGGGGGAAGGAAGCAGGGGGTGAGGT
TGGAACAGCTTTTGAGTGCAGGCAGGGGATAAAAGAGGAGGTTCAAGTCTGTCTCTCCCAACCTGCAGCT
CAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGC
CCTGGGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGTAGGTAAACAGAGCAT
GTGGCCTCAGAGGTCATCCCATTCATCTCTCTGCCTCAAGGCTCCACCCAGCAGGGAGGGGAGAAAGGAC
GCTCCCATTGGCCAAACTGCCACTGTGTGCTGTACACATTTGTACCTTATTATTATTATTATTATTATTA
TTATTATCATCATCATCATCATCATCATCATCATTTTTGAGATAGAGTCTCACTCTGTCACCCAGGCTGG
AGTGCAGTGGTGTGATCTCAGTTCATTGCAACCTCCACCTCCCAGATTCAAGCGATTCTCATGTCACAGC
CTCCCGAGTAGCTGGGATTACAAGTGTGTGCCGCCATGCTTGGCTAATTTTGCATTTTTAGTAGAGACGG
AGTTTCGCCATGTGTCTCGAACTCCTGGGCTCAAGTGATCCGCCCACCTCGGCCTCGCAAAGTTCTGGGA
TTATAGGTGTGAGCCACTGCACCTGGGCTGTACCTATTTTTTTAAAAGGAAAAAAAAAGTTTGTGAGGAA
AAAAGAAGTGTGTGTGTATATATACACATACATACACACTTTTATGTGTATATATACATAAAAGAAATTA
TGAATATATATAAAAATTATGACTATATATATACATAAAAGAAAGTGTATATATATATAGTTTCTTTTAA
AGGGACGGGGTCGACTGGGCGTAGTGGCTCATGCCTGTTATCCCAGCACTTTGGGAGGCCGAGGCGGGTG
GATCACCTGAGGTCAGGAGTTCAAGACCAGCCCGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAAAATTAGCTGGGCATGGTGGCAGGCGCCTGTAATGCCAGCTACTTGGGAGGCTGAGGTAAGGGAAT
CGCTTGATCCTGGGAGATGGAGGTTGCAGTGAGCCAAGATTGCGTCACTGCACTCCAGCCTGGGCAAGAG
AGTGAGACTCCATCTAAAAGAAAGAAAGAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAGAGAAAG
AGAGAGAGAGAGAAGGAGAGAAAGAGAGAGAGAAAGAAAAGAGACAGGTCTCACTGTTACCCAGACTGGA
GTGCAGTGGCACAATCATGGCTCACTGCAACCTTGAACTCCTGAGCTGAAAGCAATCCTCCCACCTCATC
CTCCCGAGTAGCTGAGACTACAGGTGCGCGCCAACGTGCCCGGCTCACATTTACACCCTTTAAAGCTATG
TTGCTTTCTTGACAACCCTGCACCTCTCAGAGCTTGCCCTATTTTGCAGAGGCAGAAACGGAGGCATTGC
CTGCAACTCCTCTCCCCAACAAGATTAAGTCCTCAGTAGAGGATATGGGTTGGGGCGGGCGGCGCTATCC
CTGGTGCTGAAATATCTTCTAAAGCTGCCGGTGACTCCGCACTTGTTAGGGAATTCTAAATTCCACGGAA
AAGTAGAAGGAGACAAAGAGGGGAAAGTCAGTAGTGATAACAGTACCTGCTCACACTTCTTGAGTCTCAG
ACTTCACAGTCATCAGGCCTTTATCGAGTCCTCCTCTGTGCTGGACGCTATTTTAGGCACTGGGGATGCA
GCAGTGAATGGAACCGTGTGCTGGACCCTCCCAGCCATCCATTAATGTCTTTGTTTTGTTTTGTTTTGTT
TTTTTGAGATGGAGTTTCACTCTGGTCGCCCAGGCTGGAGTGCAATGGTGCGATGTTGGCTCACTGCAAC
CTCTGACTCCCGGGTTCAAGCAATTCTCTTACCTCAGCCTCCCGAGTAGCTGGGATTACAAGCGCCCACC
CCCACGCCTGGCTAATTTTTGTATTTTTAGTAGAAATGGGGTTTCGCCATGTTGGCCAGACTAGTCTCGA
ACTCCTGACGTCAAGTGATCCCCTGCCTTGGTCTTCCAAAGTGCTGGGACTACAGGCGTGAGCCACCGTG
CCCAACCTCCAATGATGTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAGAAACAGGGTCTCACTCTGTCA
CCAAGCTGGAGTGCAGTGGCACAATGACGGCTCACTGCAGCCTCGACCTCTTGGGCTCAAGCAATCCTCC
TGCCTCAGCCTCCCAAGTAGCTGAGACTAGAGGCACACACCACCATGCCTGGCTAATTTTTTAATATTTT
GTAGAGATGGGTTCTTGCTATGTTGCCTAGGCTGGTCTCCAACTACTGGGCAACTCTAAGCAATCCTATT
GCCTTAGACTCCCAAAGTGCAATTATGAGCCACCATACCTGGCCTCACTGATGTTTTATTACAACTTCAC
TGTGTAGATGAGGAAACTGAGGCTCAGAGGCTTGCCAGGGTCCCTTAGTGGGACTGGAGCCTGTTAGACT
TCATAGACCAGGGATCTCCTTTCTCCTTCCCAGGACCTGGTCTCCAACCCCCATGACCCCTTCACTGAAT
GCCTGGATTTCTCCATTTCTCCCCGCCTCTCAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTT
GTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAAC
TTGGTCAAGGTCAGTCTTAGGCTGGGTTCCCAGATCTAGAGGCAGCCAAGTGACTTTAGGACGTGACCAC
AGCTCAGGGGAGGGACATGGTATATCAGCACCTTTCTCCATCGCTCATTATCTCCAGTCAAAAGACTCTA
TTGGGAGCTGATTCATCCTCAACAGTTTTTATCTCCCTTCACAAGGACTGAACAGAGTTTAATACTATTC
CTTTTTGTTTGTTTGTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATC
TCGGCTCACTGCAACCTCCACATCCCGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGCTA
CTACAGGCGCATGCCACCGCACCCAGCTAATTTTTATGTTTTTAGTAGAGATGGGGTTTCACCATGTTGC
CCAGGCTGGTCTCGAACTCCTGACCTCAAATGATCCACCCACCTTAGACCCCCAAAGTGCTGGGATGACA
GGCATGAGCCACCGAGCCCAGCCTCATCTTCAAGTTTTTGTTATCTCCCTTCATAAGGACTGAACAAAGT
TGAATACTATTCCTTTTTGTCGTTATCTGTTTTTACAGTGACTTCCAATCTTTGGCAGGTGAAACTGGTG
TGCTGTTAGGGTATTGATGTAAAGTCTCTTCTTAAAATAAAATTACTTAATTCAAAAGTGAGTCAACTTG
GGGAAAAAATCTTACATAAGAAACACAACAGATGGTAAACCGATTTTGGCTAAAACCGCGTGGTTGCTTT
GTGAATTCCCAGAGTTTGGAAAATGCTGTCCCTGGGGGACCTGATCCCATGCCTACCCCTGTTTTGGAAT
CCCTGTTCCATTCTCTCATTTATTGAGCACCTGCTGTGTACCCAGTCCTGCTCTGGGCTATGGTCTAAGA
CCCCCACCCCACCCTCATCTAGCAGGGGCAGGTGAAAACTAAAAAGAGAAACATGTAGGGTCTGTCTCAG
TATGTGATAAGCATTCAAAAGATAATACAACCAGATGCTGTCAGGCCGGGCACGGTAGCTCACGCCTGTA
ATCCCAGCACTTTGGGAGGTTGAGGTGGATCGCTTGAGGCCAGGAGTTCAAGACCAGCCTGTCGAACATG
GCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCGTGTGCCTGTAATCCCAGCT
ACTCAGTGGAATGAGGCAGAAGAATTGAACAATTGAACCCGGGAGGTAGAGGTTGTAGTGAGCTGAGATC
GCGCCACTGCATTCCAGCCTGGGTGACAGAGCAAGACTTCGTCAAAAAGATAGGAAAGCAGGAAGGGAGG
GAGGGAGGGAAAAGAAGGAAGGAAAGGAAAGAGCCAGGCGTGATGGCTCACCCCTGTAATCCCAGCACTT
TGGGAGACTTAGGCAGGTGCATCACCTGAGGTCAGGAGTTCGAGACCACCCTGGCCAACATGGTGAAACC
CCATCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGTGCATGCCTATAATTCCAGCTATTCGGA
AGGCTGAGGCAGGAGAATCGATTGAACTCAGGAGGTGGAGGTTGCAGAGAGCAGAGATTGTGCCATTGCA
CTCCAGCCTGGGCAACAACAGCCAGACACTGTCAGAAAGAAAGAAAAGACAGAGAGAGAGAGAGAGAGAG
AGAGAGAGAGAGAGAGAGAGAGAGAGCAAGCTAAAAAGAAAAACGTGTAGGGTCTCAGCATGATAAATAT
TCAAAGGATAATAAAACCGGATGCTGTGATGGGGAGCAACTTTAGCCAGGGAAGTCAGGGGTGGCCTCTT
GGGAGAGGTGACATTGATTGACCCTGAGTTAGGAGAAGAGGAACCAGCCACAGACAGGAACAGCTTTGAC
TGAGAAGGGGATTGGGAGGGGAGGGGTTTGCCTGAAGGTGTTTAAAGCTCCCTCCAGCTGCCCTAGAGAA
GTGTTTATCTTTTCTTTCTTTCCTCTTTTCTTTTCCTTTCTCTTCTTTTCTTTTTTTTCTTTCTCTCTCT
TTTTTTGTTCTTTATTATTTTATTTTTCTTTTTTGTTGTCTTTGTTTTATTTGTGTGTTTTTTTTCTTTT
TTGTCTTTTTTTTTTTTCCTTTTTTTGAGATAGGGACTCACTCTATTGCCCAGGCTGGAGTGTAGTGGCA
TGACCATGGCTCACTGCAGCCCCAACCTCCATGGTCCGAGAAATTCTCCCATCTTTCAACCTCCTGAGTA
GCTGGGATTATAGGCATGCACCACCGAGTCTGGTTAATTTTTTTATTTTTGGTAGAGATGGGGTTTTGCC
ATATTGGCCAGGCTGGTCTTAAACTCCTGGGCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTAG
GATTACAGGGGTGAGCCACCGTGCCCGGCCAGAAATATTTATTTTCTTGAAGGTGAACAGGCAGAGAAGC
AGAGAAAGGAGGGAGGAACTATAGCAGGCATCTGAGAAAGCGTTGATGGCCTGGGCTGTAGGTGACATGT
GAGTGGGGAAGAGAAGCGCATGGAAATTTTGGAGGCAGAGCGGGCAGGACTGGCCCGTGCACTGAGCAAG
GGGATAGTATGCAATTCTGTGCACGCCCCGTCCCGCCAGGTCATCAGTAGCCCATCTGGGAGATGAGCTG
ACACGGAACAGGGTGGGGACAGGGTCTCTGATGGGGTCTCTTTTTCCCACTTTTCCCCAGGGTCCTGAAG
AACTCCCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGG
GCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAG
GAGACAAACCTCTGAGGACAGGGCCAGCCGCGGGACTGACACCCTGGGATGGAACCTCAGGATGGGCCAA
ACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTGGCTGGATTGCCTTGTATGCAAATGAGTTCAGGA
CTACAATACCCTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCCAGCCCCTTGCTTC
AACCGTCCCCAGTATTAGACGCTGCAGCCCTGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCT
CTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGA
TCTCGGCTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGG
GATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGT
TGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGTTA
CAGGCGTAAGCTACCATGCCCAGCCTACCGTTTTTCTCAATCTATAATAGAAAGCCACCACGCCCAGGTA
ATTTTTGTAATTTTGTATTTTTGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTG
ATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGGCTGGGATTACAGGGGTGAGCCACCGCGCCCCAC
CTCTTTCTTATTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCCTCCAACCTTGGCC
CACACACCTGCCATGGCTCCCATCATCCTGAGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTC
TCGAATTGGGTTGTGTCCCCCCAAAATTTATGTCTACCCAGAACCTCAGAACATGAGCTTACTTGGAAAT
AGGGTCTTTGCAGGTGTAACTGGTTAAATTAAAAGAGGTATTACTGGAGGAGGATGGATGAATCCAGTGA
CTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGGGAAGATGCCACGTGAAGACAGAG
GCAGTGGTTGGATCAATGCATCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCAGGA
GGGGGGCATGAGATGCATTATTTCTTAGAGCCTTTAGAGGGAACATGGCCCTACTGACACCTTGATGTCA
GACTTCTGGCTGCTAGAACTGTCAGAGAATAAATTTCTGTTGTTTGATGCCA
Protein Information
Protein Name transcript variant X1
NCBI Protein GI 4507035
Protein Accession NP_000444
Protein pI 7.43
Protein Weight 63209.43
Protein Length 643
Protein Note Also known as NIS; TDH1
Protein Sequence 
>NP_000444.1 sodium/iodide cotransporter [Homo sapiens]
MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSA
VQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVA
TMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGV
MLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKL
ALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSG
TLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVM
GVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNA
SGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAP
GLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCV
GHDGGRDQQETNL
Epitope Information
IEDB Linear Epitope