VIOLIN: Vaccine Investigation and Online Information Network

NP from Influenza A virus (A/nt/60/1968(H3N2))

General Information

Protegen ID

718

Sequence Strain (Species/Organism)

Influenza A virus (A/nt/60/1968(H3N2))

VO ID

VO_0011264

Taxonomy ID

384505

Other Database IDs

CDD:278907

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with Recombinant-derived nucleoprotein (rNP) from S. typhimurium expressing the cloned NP gene from A/NT/60/68 (Jones & Brownlee, 1985) were protected against a lethal challenge with Influenza A/Puerto Rico/8/34 (A/PR8) virus but showed considerable morbidity before recovery (Tite et al., 1990).

Related Vaccines(s)

Influenza virus NP protein vaccine (Influenza A virus (A/nt/60/1968(H3N2)))

References

Tite et al., 1990: Tite JP, Hughes-Jenkins C, O'Callaghan D, Dougan G, Russell SM, Gao XM, Liew FY. Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. II. Protection from influenza infection and mechanism of protection. Immunology. 1990; 71(2); 202-207. [PubMed: 2172156].

Gene Information

Gene Name

NP from Influenza A virus (A/nt/60/1968(H3N2))

Protein Information

Protein Name

nucleoprotein

NCBI Protein GI

324704

Protein pI

9.55

Protein Weight

54488.67

Protein Length

574

Protein Note

Influenza virus nucleoprotein; pfam00506

Protein Sequence

>AAA43465.1 nucleoprotein [Influenza A virus (A/nt/60/1968(H3N2))]
MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSA
FDERRNKYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKGEIRRIWRQANNGDDATAGLTHMMIWH
SNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGE
NGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACV
YGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRVLSFIRGT
KVSPRGKLSTRGVQIASNENMDAMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPAFSVQRNLPF
DKPTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEMSFQGRGVFELSDEKAANPIVPSFDMSNEGSYFFG
DNAEEYDN

Epitope Information

IEDB Linear Epitope