Study demonstrated that a recombinant construction of heat-shock protein (hslU) with lypopolysaccharide (rcHSP-LPS) administered 24 hours before inoculation induced resistance to S. typhimurium infection. Protection formed after 3 injections of rcHSP-LPS with 10 mcg in each or single injection with 100 mcg/mouse. Forty to eighty percent of immunized mice survived after challenge while 90% of control animals died. Destruction of the HSP by boiling of the construction led to loss of protective effect (Vorob'ev et al., 2009).
References
Vorob'ev et al., 2009: Vorob'ev DS, Semenova IB, Kurbatova EA, Sveshnikov PG, NaroditskiÄ BS, Logunov DIu, Vaneeva NP. [Assessment of protective effect of heat shock protein-lypopolysaccharide of Salmonella typhimurium recombinant construction in mice]. Zhurnal mikrobiologii, epidemiologii, i immunobiologii. 2009; (3); 38-41. [PubMed: 19621817].
