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TviB

General Information
Protegen ID 729
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhi str. Ty2
VO ID VO_0011269
Taxonomy ID 209261
Molecule Role Protective antigen
Molecule Role Annotation The viaB (tviB) gene coding for the Vi antigen of Salmonella typhi Ty2 was subcloned into expression vector pYA248. The recombinant plasmid was termed SMM202 and transformed into Salmonella typhimurium χ4072, an attenuated ΔcyaΔcrp mutant. Immunization of mice with Vi4072 afforded complete protection against fatal infection with virulent S. typhi Ty2 (Cao et al., 1992).
Related Vaccines(s) S. typimurium Vi4072
References
Cao et al., 1992: Cao Y, Wen Z, Lu D. Construction of a recombinant oral vaccine against Salmonella typhi and Salmonella typhimurium. Infection and immunity. 1992; 60(7); 2823-2827. [PubMed: 1612747].
Gene Information
Gene Name TviB
NCBI Gene ID 1067316
Genbank Accession AE014613
Locus Tag t4352
Gene Starting Position 4505426
Gene Ending Position 4506703
DNA Sequence 
>NC_004631.1:4505426-4506703 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete genome
ATTACAATCTCACATCTGACTGCTCAGCCGGAAGAACATACTTCAAATCATAAAGTACATGTTTATCTTT
TCCGAAGCCGCGAATATCCTCACTTCCCATCTGTTTAAATTGCTGATGTCCTACTGCAACAATGATCGCA
TCGTAGTGGCTTGATTTGACTTCCGATACCGGGATAATGCCATACTCTCGTCTTACCTCTTCGGCATCCA
CCCATGGATCAAAAATATCCACTTTACAACTATATTTACCGAGTTCCTTTACCACATCAATAATGCGTGT
ATTTCTGATGTCCGGACAGTTTTCTTTAAAGGTAAAGCCGAGAATCAGCACGCTGGAACCCTCAACGTTA
ATTCCTTTTTTGATCATTGCTTTGATCAACTGCTCGGAGACATAGTTGCCCATGTTGTCGTTCAGGCGGC
GTCCTGCAAGTATGATTTCTGGATAATAGCCAATGCCCTGAGATTTATGTGTCAGATAATAGGGATCTAC
GCCAATACAGTGACCACCGACCAGTCCCGGACGGAATGGCAGGAAATTCCATTTGCTGCCAGCGGCACGT
AGCACGGCTTCAGTATCGATATTTAAACGATTAAAAATAATCGCCAGCTCATTGACCAAGGCAATATTCA
GATCGCGTTGCGTATTTTCAATCACCTTCGCTGCCTCAGCAACTTTGATGCTCTCTGCTTTATATGTACC
TGCGCTGATGATCTGCTGATATACTTCATCGATAAGTTCGGCGATCTGTGCGGTTGAACCGGAGGTGATT
TTCTTGATGTTGGTTAAACGGTGCTTTTTATCACCGGGATTGATCCTTTCCGGGCTATAACCGACATAGA
AATCCTGGTTGAAAGTCATTCCGGACATACGAGCAAGGATCGGCACGCATTCTTCTTCGGTACATCCCGG
ATATACCGTAGATTCATATACCACAATATCTCCCCGATTCAGCACTGTACCAACGGTTTCACTCGCCTTG
ATTAGTGGGGTGAGGTCTGGTTGCTTGTAGGTATTTATCGGCGTCGGGACGGTGATGATGTAAAAATTAC
ATTCTTTGATCTTCTCAATCTCGGAAGTAAATTTCAGATAACGAGCCTCACGTAATTCTTCTTCAGTGGT
TTCCAGATTGACATCCACCCCATTCTTTAATTCAAGAATACGCTTTTTATTAACGTCGAAGCCAACAACC
TGACGAGATTTGCCAAATTCAACTGCCAGAGGAAGCCCAACATATCCCAGCCCAATAATCGCGATTTTTA
CCTCGTCTATACCGAACA
Protein Information
Protein Name VI polysaccharide biosynthesis UDP-glucose/GDP-mannose dehydrogenase
NCBI Protein GI 29144603
Protein Accession NP_807945
Protein pI 5.79
Protein Weight 43904.75
Protein Length 425
Protein Note corresponds to STY4661 from Accession AL513382: Salmonella typhi CT18
Protein Sequence 
>NP_807945.1 VI polysaccharide biosynthesis UDP-glucose/GDP-mannose dehydrogenase [Salmonella enterica subsp. enterica serovar Typhi str. Ty2]
MFGIDEVKIAIIGLGYVGLPLAVEFGKSRQVVGFDVNKKRILELKNGVDVNLETTEEELREARYLKFTSE
IEKIKECNFYIITVPTPINTYKQPDLTPLIKASETVGTVLNRGDIVVYESTVYPGCTEEECVPILARMSG
MTFNQDFYVGYSPERINPGDKKHRLTNIKKITSGSTAQIAELIDEVYQQIISAGTYKAESIKVAEAAKVI
ENTQRDLNIALVNELAIIFNRLNIDTEAVLRAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKSQGIGYYP
EIILAGRRLNDNMGNYVSEQLIKAMIKKGINVEGSSVLILGFTFKENCPDIRNTRIIDVVKELGKYSCKV
DIFDPWVDAEEVRREYGIIPVSEVKSSHYDAIIVAVGHQQFKQMGSEDIRGFGKDKHVLYDLKYVLPAEQ
SDVRL
Epitope Information
IEDB Linear Epitope