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tcpA

General Information
Protegen ID 732
Sequence Strain (Species/Organism) Vibrio cholerae O1
VO ID VO_0011271
Taxonomy ID 127906
Other Database IDs CDD:283573
Molecule Role Protective antigen
Molecule Role Annotation Antibodies against TCP were able to protect baby mice against challenge with V. cholerae O1 of the classical but not of the El Tor biotype (Osek et al., 1994).
References
Osek et al., 1994: Osek J, Jonson G, Svennerholm AM, Holmgren J. Role of antibodies against biotype-specific Vibrio cholerae pili in protection against experimental classical and El Tor cholera. Infection and immunity. 1994; 62(7); 2901-2907. [PubMed: 7911787].
Gene Information
Gene Name tcpA
Protein Information
Protein Name TcpA
NCBI Protein GI 21616882
3D structure: PDB ID 1OQV
Protein pI 7.25
Protein Weight 18548.51
Protein Length 239
Protein Note non-toxic;
serogroup: O1; biotype: EVC
Protein Sequence
>AAM66403.1 TcpA, partial [Vibrio cholerae O1]
IMGVVSAGVVTLAQRAIDSQNMTKAAQSLNSIQVAMTQTYRALGNYPATADAAAAAKLTTGLISLGKISA
DEAKNPFTGGNMNIFSFSRNAAQNKAFAITVDGLTQAQCKTLITSVGDMFPYVAIKAGAAIAFGDLTDFE
TTQADAAAGAGVIKSIAPASKNLDLTNIIHVEELCKGAAPFGVAFGNS

Epitope Information
IEDB Linear Epitope