VIOLIN: Vaccine Investigation and Online Information Network

TcpF

General Information

Protegen ID

733

Sequence Strain (Species/Organism)

Vibrio cholerae O1 biovar El Tor str. N16961

VO ID

VO_0011272

Taxonomy ID

243277

Other Database IDs

GDB:5363132

Molecule Role

Protective antigen

Molecule Role Annotation

Antibodies generated against TcpF are protective against experimental V. cholerae infection in the infant mouse cholera model (Kirn and Taylor, 2005).

References

Kirn and Taylor, 2005: Kirn TJ, Taylor RK. TcpF is a soluble colonization factor and protective antigen secreted by El Tor and classical O1 and O139 Vibrio cholerae serogroups. Infection and immunity. 2005; 73(8); 4461-4470. [PubMed: 16040956].

Gene Information

Gene Name

TcpF

NCBI Gene ID

2614504

Genbank Accession

AE003852

Chromosome No

Locus Tag

VC0837

Gene Starting Position

898672

Gene Ending Position

899688

DNA Sequence

>NC_002505.1:898672-899688 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete sequence
TATGAGATATAAAAAAACCTTAATGTTATCAATCATGATTACATCATTTAACTCATTTGCATTTAATGAT
AATTATAGTTCAACCAGTACGGTTTATGCTACGTCTAATGAAGCTACGGATTCAAGGGGGAGTGAGCACC
TTAGATACCCTTATTTAGAGTGTATCAAAATCGGTATGAGTAGAGATTATCTTGAAAACTGTGTGAAAGT
ATCTTTTCCAACCTCTCAAGATATGTTTTATGACGCATACCCATCGACAGAATCTGACGGTGCTAAGACA
AGAACAAAAGAAGATTTCTCTGCTCGGCTTTTAGCTGGTGATTATGATAGTTTACAGAAATTGTATATAG
ATTTTTATCTTGCTCAAACGACTTTCGATTGGGAAATACCGACAAGGGATCAAATTGAGACACTAGTTAA
TTATGCTAATGAAGGTAAATTGTCTACGGCACTTAATCAAGAGTATATTACAGGTCGATTTCTTACAAAA
GAAAATGGTCGATATGATATTGTGAATGTTGGTGGTGTTCCAGATAATACTCCAGTTAAACTACCAGCTA
TTGTTTCTAAACGCGGACTAATGGGTACAACTTCTGTAGTTAATGCAATTCCCAATGAAATTTATCCTCA
TATCAAAGTTTATGAAGGGACTCTTAGTCGTTTAAAACCTGGTGGTGCAATGATCGCAGTATTAGAATAT
GACGTAAGTGAATTAAGTAAGCACGGGTATACCAATCTGTGGGATGTGCAGTTTAAGGTTCTTGTTGGAG
TTCCACATGCAGAAACAGGAGTTATCTATGACCCTGTTTATGAAGAAACTGTCAAACCATATCAGCCTAG
TGGCAACTTAACGGGTAAGAAGTTGTATAATGTATCTACAAATGACATGCATAATGGTTACAAGTGGTCA
AATACTATGTTCTCAAATTCTAATTATAAAACGCAAATATTATTAACTAAAGGAGATGGAAGTGGTGTGA
AACTGTATAGCAAAGCATATTCAGAGAACTTTAAATA

Protein Information

Protein Name

toxin co-regulated pilus biosynthesis protein F

NCBI Protein GI

15640854

Protein Accession

NP_230485

Protein pI

6.37

Protein Weight

35844.42

Protein Length

338

Protein Note

similar to SP:P29488 GB:L01623 PID:155281 PID:155284 PID:48417; identified by sequence similarity; putative

Protein Sequence

>NP_230485.1 toxin co-regulated pilus biosynthesis protein F [Vibrio cholerae O1 biovar El Tor str. N16961]
MRYKKTLMLSIMITSFNSFAFNDNYSSTSTVYATSNEATDSRGSEHLRYPYLECIKIGMSRDYLENCVKV
SFPTSQDMFYDAYPSTESDGAKTRTKEDFSARLLAGDYDSLQKLYIDFYLAQTTFDWEIPTRDQIETLVN
YANEGKLSTALNQEYITGRFLTKENGRYDIVNVGGVPDNTPVKLPAIVSKRGLMGTTSVVNAIPNEIYPH
IKVYEGTLSRLKPGGAMIAVLEYDVSELSKHGYTNLWDVQFKVLVGVPHAETGVIYDPVYEETVKPYQPS
GNLTGKKLYNVSTNDMHNGYKWSNTMFSNSNYKTQILLTKGDGSGVKLYSKAYSENFK

Epitope Information

IEDB Linear Epitope