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LACK

General Information
Protegen ID 734
Sequence Strain (Species/Organism) Leishmania major
VO ID VO_0011260
Taxonomy ID 5664
Other Database IDs CDD:238121
CDD:225201
CDD:293791
Molecule Role Protective antigen
Molecule Role Annotation Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge. A truncated portion of the LACK antigen (LACKp24) was able to induce the highest protective effect compared to other constructs. The DNA vaccine encoding LACK was able to induce partial protection in mice (Ahmed et al., 2009).
Related Vaccines(s) L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa , L. major DNA vaccine encoding TSA, LMSTI1, KMP11, and LACK , L. major DNA vaccine pcLACK + IL-22
References
Ahmed et al., 2009: Ahmed SB, Touihri L, Chtourou Y, Dellagi K, Bahloul C. DNA based vaccination with a cocktail of plasmids encoding immunodominant Leishmania (Leishmania) major antigens confers full protection in BALB/c mice. Vaccine. 2009; 27(1); 99-9106. [PubMed: 18951941].
Gene Information
Gene Name LACK
NCBI Nucleotide GI 1276476
DNA Sequence 
>gi|1276476|gb|U27568.1|LMU27568 Leishmania major activated protein kinase C receptor homolog LACK mRNA, complete cds
AACTAACGCTATATAAGTATCAGTTTCTGTACTTTATTGATAAGTTTCTTCTCACTCCACTTCGTTTCAC
CATGAACTACGAGGGTCACCTGAAGGGTCACCGAGGATGGGTCACCTCCCTGGCCTGCCCGCAGCAGGCG
GGGTCGTACATCAAGGTGGTGTCGACGTCGCGCGATGGTACGGTCATCTCGTGGAAGGCCAACCCCGACC
GCCACAGCGTGGACAGCGACTACGGTCTGCCGAACCACCGCCTCGAGGGCCACACCGGCTTCGTGTCGTG
CGTGTCGCTGGCCCACGCCACCGACTACGCGCTGACCGCGTCCTGGGACCGCTCCATCCGCATGTGGGAC
CTGCGCAATGGCCAGTGCCAGCGCAAGTTCCTGAAGCACACCAAGGACGTGCTCGCCGTCGCCTTCTCGC
CGGACGACCGCCTGATCGTGTCCGCGGGCCGCGACAACGTGATCCGCGTGTGGAACGTGGCGGGTGAGTG
CATGCACGAGTTCCTGCGCGACGGCCACGAGGACTGGGTGAGCAGCATCTGCTTCTCGCCGTCGCTGGAG
CACCCGATCGTGGTGTCCGGCAGCTGGGACAACACCATCAAAGTATGGAACGTGAACGGGGGCAAGTGTG
AGCGCACGCTCAAGGGCCACAGCAACTACGTGTCCACGGTGACGGTGTCGCCAGACGGGTCTCTGTGCGC
ATCTGGCGGCAAGGACGGCGCGGCGCTGTTGTGGGACCTGAGCACCGGTGAGCAGCTGTTCAAGATCAAC
GTGGAGTCGCCCATCAACCAGATCGGCTTCTCGCCCAACCGCTTCTGGATGTGCGTCGCGACGGAGAGGT
CTCTGTCCGTGTACGACCTGGAGAGCAAGGCCGTGATTGCGGAGCTGACGCCGGACGGCGCGAAGCCGTC
GGAGTGCATCTCCATTGCCTGGTCCGCCGACGGCAACACTCTGTACTCCGGCCACAAGGACAACCTGATC
CGCGTGTGGTCCATCTCCGACGCCGAGTAATGGCCGCGCGCTGCTCGTGCCGGACGGCGTGGTAGGCGAG
GGAGAACGAGCGAGAAGTGA
Protein Information
Protein Name LACK
NCBI Protein GI 1276477
Protein Accession AAA97577.1
Protein pI 6.64
Protein Weight 32575.5
Protein Length 354
Protein Note WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Protein Sequence 
>AAA97577.1 LACK [Leishmania major]
MNYEGHLKGHRGWVTSLACPQQAGSYIKVVSTSRDGTVISWKANPDRHSVDSDYGLPNHRLEGHTGFVSC
VSLAHATDYALTASWDRSIRMWDLRNGQCQRKFLKHTKDVLAVAFSPDDRLIVSAGRDNVIRVWNVAGEC
MHEFLRDGHEDWVSSICFSPSLEHPIVVSGSWDNTIKVWNVNGGKCERTLKGHSNYVSTVTVSPDGSLCA
SGGKDGAALLWDLSTGEQLFKINVESPINQIGFSPNRFWMCVATERSLSVYDLESKAVIAELTPDGAKPS
ECISIAWSADGNTLYSGHKDNLIRVWSISDAE
Epitope Information
IEDB Linear Epitope