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TSA

General Information
Protegen ID 735
Sequence Strain (Species/Organism) Leishmania major
VO ID VO_0011273
Taxonomy ID 5664
Other Database IDs CDD:140280
CDD:239313
Molecule Role Protective antigen
Molecule Role Annotation Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major. Mice inoculated pCMV3ISS-TSA developed significantly smaller lesions in their footpads after challenge with the parasite. The vaccine was able to induce a partially protective effect (Ahmed et al., 2009).
Related Vaccines(s) L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa , L. major DNA vaccine encoding TSA, LMSTI1, KMP11, and LACK , LEISH-F1+MPL-SE
References
Ahmed et al., 2009: Ahmed SB, Touihri L, Chtourou Y, Dellagi K, Bahloul C. DNA based vaccination with a cocktail of plasmids encoding immunodominant Leishmania (Leishmania) major antigens confers full protection in BALB/c mice. Vaccine. 2009; 27(1); 99-9106. [PubMed: 18951941].
Gene Information
Gene Name TSA
NCBI Nucleotide GI 3411093
DNA Sequence 
>gi|3411093|gb|AF044679.1| Leishmania major thiol specific antioxidant (TSA) mRNA, complete cds
CTGTACTTTATTGCCACCAGCCAGCCATGTCCTGCGGTAACGCCAAGATCAACTCTCCCGCGCCGTCCTT
CGAGGAGGTGGCGCTCATGCCCAACGGCAGCTTCAAGAAGATCAGCCTCTCCTCCTACAAGGGCAAGTGG
GTCGTGCTCTTCTTCTACCCGCTCGACTTTAGCTTCGTGTGCCCGACAGAGGTCATCGCGTTCTCCGACA
GCGTGAGTCGCTTCAACGAGCTCAACTGCGAGGTCCTCGCGTGCTCGATAGACAGCGAGTACGCGCACCT
GCAGTGGACGCTGCAGGACCGCAAGAAGGGCGGCCTCGGGACCATGGCGATCCCAATGCTAGCCGACAAG
ACCAAGAGCATCGCTCGTTCCTACGGCGTGCTGGAGGAGAGCCAGGGCGTGGCCTACCGCGGTCTCTTCA
TCATCGACCCCCATGGCATGCTGCGTCAGATCACCGTCAATGACATGCCGGTGGGCCGCAGCGTGGAGGA
GGTTCTACGCCTGCTGGAGGCTTTTCAGTTCGTGGAGAAGCACGGCGAGGTGTGCCCCGCGAACTGGAAG
AAGGGCGCCCCCACGATGAAGCCGGAACCGAATGCGTCTGTCGAAGGATACTTCAGCAAGCAGTAAACCT
GTGAGCGTCGCAGGAGTCAGTGTGACCTCACCCGCCTCTGCCAGTGGGTGCGAGAGGGCGTGAGGGATTG
TGGGAAGGCTGTTGGATATGATGCAGACAGCGATGAATGCAACTCCCACACACTGGCCCTCCTCAGCCCT
CTCCACACAGACACACGCACGCATGTGCGGTGCTTCTGCTCCTTCATTTCCTGATGCGGTTTCTTTACTA
TTTATGTTTTCCCCTGTTTTGGTTTCGCGGAATATGGACGCACGAACGCAGAGAGCAGAGGCGCGACACA
CACACACGGGGCGCACACGTGTAAGCGACGGAGCGCGACACAGAGGGGAGAAGCCGGAAAGGATATATGA
AATGAAGATGGTGTCCCGCACACACAGGCACGCACACGGGGCGAACGCGTGGCGCGTCCTTTCTATGGTT
TCGCTGCTGCTGTTCGTGTTCTCGCTTCGCTGGTTGCAGTTCCGGCTCGTGCTGCCCTGCCTGCCACTCT
TGGTCCGTGTCTGTCCGTGTCCGTGTCCGTGTGGGGGGGGGAGAGTTTTTCACTCCCCCGGTCACCTCTA
CTGTTTATTATTTATATGTTTATTTATTTCCATATTGACTCAATTCATTCCGTGCGAAAGCCGGCTTGTT
CCGGCGTCTTTTGACGAACAACTGCCCTATCAGCTGGTGATGGCCGTGTAGTGGACTGCCATGGCGTTGA
CGGGAGCGGGGGATTAGGGTTCGATTCCGGAGAGGGAGCCTGAGAAATAGCTACCACTTCTACGGAGGGC
AGCAGGCGCGCAAATTGCCCAATGTCAAAACAAAACGATGAGGCAGCGAAAAGAAATAGAGTTGTCAGTC
CATTTGGATTGTCATTTCAATGGGGGATATTTAAACCCATCCAATATCGAGTAACAATTGGAGGACAAGT
CTGGTGCCAGCACCCGCGGTAATTCCAGCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAA
Protein Information
Protein Name thiol specific antioxidant
NCBI Protein GI 3411094
Protein Accession AAC31146.1
Protein pI 6.75
Protein Weight 20885.27
Protein Length 261
Protein Note tryparedoxin peroxidase; Provisional
Protein Sequence 
>AAC31146.1 thiol specific antioxidant [Leishmania major]
MSCGNAKINSPAPSFEEVALMPNGSFKKISLSSYKGKWVVLFFYPLDFSFVCPTEVIAFSDSVSRFNELN
CEVLACSIDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARSYGVLEESQGVAYRGLFIIDPHGMLR
QITVNDMPVGRSVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPNASVEGYFSKQ
Epitope Information
IEDB Linear Epitope