VIOLIN: Vaccine Investigation and Online Information Network

PSA-2

General Information

Protegen ID

742

Sequence Strain (Species/Organism)

Leishmania major

VO ID

VO_0011279

Taxonomy ID

5664

Other Database IDs

CDD:215061
CDD:275380

Molecule Role

Protective antigen

Molecule Role Annotation

Intraperitoneal vaccination of C3H/He mice with PSA-2 with Corynebacterium parvum as an adjuvant resulted in complete protection from lesion development after challenge infection with virulent L. major. Significant protection was also obtained in the genetically susceptible BALB/cH-2k and BALB/c mice (Handman et al., 1995).

Related Vaccines(s)

L. major PSA-2 Protein Vaccine

References

Handman et al., 1995: Handman E, Symons FM, Baldwin TM, Curtis JM, Scheerlinck JP. Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response. Infection and immunity. 1995; 63(11); 4261-4267. [PubMed: 7591056].

Gene Information

Gene Name

PSA-2

NCBI Gene ID

5649964

Protein Information

Protein Name

surface antigen 2

NCBI Protein GI

1129058

Protein pI

4.54

Protein Weight

37463.69

Protein Length

441

Protein Note

leucine-rich repeat receptor-like protein kinase; Provisional

Protein Sequence

>AAB38549.1 surface antigen 2 [Leishmania major]
MAQCVRRLVLAATLAAAVALLLCTSSAPVARAAGTGDFTAAQRTNTLAVLQAFGRAIPKLGEKWAGNDFC
SWEAVLCNAPDVYVSGISPTYAGTLPEMPVNVDYRHVVIKQLDFSEMGPGLSGTLPASWHSMTSLESLSI
EKCESISGSVPPEWGSMTSLSVLNLRGTGISGTLPPQWSGMSKARSLQLQDCDLSGSLPSSWSAIPMLAS
VSLKGNKFCGCVPDSWDQKAGLVVDIEDKHKGSDCLAAKDCTTTTTKPSATTATTPNLTNFPPTPRTTTE
PLTTTSTEAPAEPTTTTEAPAEPTTTATPTNTPTPAPETECEVDGCEVCEGDSAARCARCREDYFLTDEK
TCLKHNDGGVAAVSSGVAAAAVVCVAVLFSVGLAA

Epitope Information

IEDB Linear Epitope