VIOLIN: Vaccine Investigation and Online Information Network

LIPO-A

General Information

Protegen ID

746

Sequence Strain (Species/Organism)

Leishmania infantum

VO ID

VO_0011283

Taxonomy ID

5671

Other Database IDs

CDD:140267
CDD:240221

Molecule Role

Protective antigen

Molecule Role Annotation

Study examined the immunogenic properties of the Leishmania infantum acidic ribosomal protein P0 (LiP0) in the BALB/c mouse model. When mice were immunized with pcDNA3-LiP0, noticeable protection against L. major infection was achieved (Iborra et al., 2003).

Related Vaccines(s)

pcDNA3-LiP0

References

Iborra et al., 2003: Iborra S, Soto M, CarriÃ³n J, Nieto A, FernÃ¡ndez E, Alonso C, Requena JM. The Leishmania infantum acidic ribosomal protein P0 administered as a DNA vaccine confers protective immunity to Leishmania major infection in BALB/c mice. Infection and immunity. 2003; 71(11); 6562-6572. [PubMed: 14573678].

Gene Information

Gene Name

LIPO-A

Protein Information

Protein Name

60S acidic ribosomal protein P0

NCBI Protein GI

730579

Protein pI

4.83

Protein Weight

33714.61

Protein Length

399

Protein Note

60S acidic ribosomal protein P0. /FTId=PRO_0000154772.

Protein Sequence

>sp|P39097.1|RLA0_LEIIN RecName: Full=60S acidic ribosomal protein P0
MPSITTAKREYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVGRALRAKAEFMMGKKTLQGKIVEKRAQAK
DASPEAKHFNDQCEEYNLLSGNTGLIFTNNAVQEITSVLDAHRVKRAARVGAISPCDVIVAAGSTGMEPT
QTSFFQALNIATKIAKGMVEIVTEKKVLSVGDKVDNSTATLLQKLNISPFYYQVNVLSVWDRGVLFTRED
LMMTEDMVEKMLMEGLSNVAAMALGAGIPTSSTIGPMLVDAFKNLLAVSVATSYEFEEHNGKELREAAIN
GLLAGSCSAAAEPAAAAPAAPSAAAKEEPEESDEDDFGMGGLF

Epitope Information

IEDB Linear Epitope