VIOLIN: Vaccine Investigation and Online Information Network

H1

General Information

Protegen ID

748

Sequence Strain (Species/Organism)

Leishmania infantum

VO ID

VO_0011285

Taxonomy ID

5671

Molecule Role

Protective antigen

Molecule Role Annotation

Following infection with L. infantum promastigotes, five out of eight beagle dogs immunized with H1 Montanide remained free of clinical signs, compared to two out of eight dogs in the control group. The results demonstrate that H1 antigens with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions (Moreno et al., 2007).

Related Vaccines(s)

L. infantum H1 protein vaccine

References

Moreno et al., 2007: Moreno J, Nieto J, Masina S, CaÃ±avate C, Cruz I, Chicharro C, Carrillo E, Napp S, Reymond C, Kaye PM, Smith DF, Fasel N, Alvar J. Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis. Vaccine. 2007; 25(29); 5290-5300. [PubMed: 17576026].

Gene Information

Gene Name

NCBI Gene ID

5070063

NCBI Nucleotide GI

78146499

DNA Sequence

>gi|78146499|gb|DQ232891.1| Leishmania infantum histone H1 gene, complete cds
ATGTCCTCTGATTCCGCCGTTGCTGCCCTTTCCGCTGCCATGACCTCGCCGCAGAAGTCTCCTCGCTCGT
CGCCGAAGAAGACGGCTGCGAAGAAGGCCGCGGCGAAGAAGGCCGCGGCGAAGAAGGCCGGGGCGAAGAA
GGCCGGGGCGAAGAAGGCGGTGAGGAAGGTGGCTACGCCGAAGAAGCCGGCGAAGAAGGCTGCGAAGAAG
GCCGCGAAGAAGCCGGCGAAGAAGGTCGCGAAGAAGCCGGCGAAGAAGGCTGCGAAGAAGCCGGCGAAGA
AGCCGGCGAAGAAGGCTGCGAAGAAGGCCGCGGCGAAGAAGTAA

Protein Information

Protein Name

histone H1

NCBI Protein GI

78146500

Protein Accession

ABB22792.1

Protein pI

12.41

Protein Weight

10687.41

Protein Length

155

Protein Note

L.infH1

Protein Sequence

>ABB22792.1 histone H1 [Leishmania infantum]
MSSDSAVAALSAAMTSPQKSPRSSPKKTAAKKAAAKKAAAKKAGAKKAGAKKAVRKVATPKKPAKKAAKK
AAKKPAKKVAKKPAKKAAKKPAKKPAKKAAKKAAAKK

Epitope Information

IEDB Linear Epitope