VIOLIN: Vaccine Investigation and Online Information Network

tox

General Information

Protegen ID

750

Sequence Strain (Species/Organism)

Corynebacterium diphtheriae

VO ID

VO_0011287

Taxonomy ID

1717

Other Database IDs

CDD:280859
CDD:238651
CDD:280860
CDD:279642
GOA:Q6NK15
InterPro: IPR000512
InterPro: IPR022404
InterPro: IPR022405
InterPro: IPR022406
UniProtKB/TrEMBL: Q6NK15

Molecule Role

Protective antigen

Molecule Role Annotation

In 1923, it was discovered that treatment with formalin eliminated the toxicity of diphtheria toxin (DT) without destroying its immunogenicity. Formalin‐treated DT, now called diphtheria toxoid, rapidly became the preferred vaccine against diphtheria, and diphtheria toxoid (usually in combined vaccines, such as diphtheria‐tetanus toxoids–pertussis vaccine [DTP] or diphtheria‐tetanus toxoids–acellular pertussis vaccine [DTaP] for children and tetanus‐diphtheria toxoids vaccine for adults [Td]) is still used throughout the world for active immunization against diphtheria (Holmes, 2000).

References

Holmes, 2000: Holmes RK. Biology and molecular epidemiology of diphtheria toxin and the tox gene. The Journal of infectious diseases. 2000; 181 Suppl 1; S156-167. [PubMed: 10657208].

Gene Information

Gene Name

tox

Protein Information

Protein Name

Diphtheria toxin precursor

NCBI Protein GI

38199106

Protein pI

6.37

Protein Weight

56772.07

Protein Length

638

Protein Note

biotype gravis

Protein Sequence

>CAE48728.1 Diphtheria toxin precursor [Corynebacterium diphtheriae]
MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGN
YDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLM
EQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQA
CAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTAL
EHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNT
EEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYA
VSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAID
GDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS

Epitope Information

IEDB Linear Epitope