VIOLIN: Vaccine Investigation and Online Information Network

Tc00.1047053434931.10

General Information

Protegen ID

763

Sequence Strain (Species/Organism)

Trypanosoma cruzi strain CL Brener

VO ID

VO_0011300

Taxonomy ID

353153

Molecule Role

Protective antigen

Molecule Role Annotation

C57BL/6 mice were immunized s.c. with recombinant PFR-2 (PAR2) protein co-adsorbed to alum with rIL-12. rPFR-2 immunized animals were able to successfully resolve parasitemia by day 30 p.i., with the peak parasitemia occurring between days 17 and 21 p.i. (Luhrs et al., 2003).

Related Vaccines(s)

T. cruzi DNA vaccine encoding PFR2 fused with HSP70 , T. cruzi PAR2 Protein Vaccine

References

Luhrs et al., 2003: Luhrs KA, Fouts DL, Manning JE. Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection. Vaccine. 2003; 21(21-22); 3058-3069. [PubMed: 12798650].

Gene Information

Gene Name

Tc00.1047053434931.10

NCBI Gene ID

3532027

Genbank Accession

AAHK01004051

Locus Tag

Tc00.1047053434931.1

Gene Starting Position

93194

Gene Ending Position

93988

DNA Sequence

>NW_001849495.1:93194-93988 Trypanosoma cruzi strain CL Brener 1047053517073 genomic scaffold, whole genome shotgun sequence
NCAGGACGAGGCGTGGCGCCGCATCCAGGAGCTCGAGCGTGTCCTGCAGCGTCTGGGGACGGAGCGATTT
GAGGAGGTGAAGCGCCGCATTGAGGAGAACGACCGCGAGGAGAAGCGCAAGGTGGAGTACCAGCAGTTCC
TGGATGTATGTGGGCAGCACAAGAAGCTGCTGGAGCTGTCGGTGTACAACTGCGACCTGGCGATGCGATG
CATCGGGATGATGGAGGAGCTGGTGGCGGAGGGCTGCAGCGCAATCAAGTCGCGCCACGACAAGACGAAC
GAGGAGCTGGGGGACCTGCGGCTGCAGGTGCATCAGGAGTACCTGGAGGCGTTCCGCCGCCTGTACAAGA
CGCTGGGCCAGCTGGTGTACAAGAAGGAGAAGCGCCTGGAGGAGATTGACCGCAACATCCGCACGACGCA
CATTCAGCTGGAGTTTGCCATCGAGACGTTTGACCCGAACGCGAAGAAGCACTCGGACGCCAAGAAGGAG
CTGTACAAGCTCCGCGCGCAGGTGGAGGAGGAGCTGGAGATGCTGAAGGACAAGATGGCGCAGGCGCTGG
AGATGTTTGGCCCGACCGAGGACGCGCTGAACCAGGCCGGCATTGAGTTTGTGCATCCCGCCGAGGAGGT
GGAGGACGGCAACCTGACCCGCCGCAGCAAGATGGTCGAGTACCGTGCCCACCTGGCGAAGCAGGAGGAG
GTGAAGATTGCGGCGGAGCGCGAGGAACTGAAGCGCTCCAAGACACTGCAGAGCCAGCAGTACCGCGGCA
AGACGGTGCAGCAGATCACACAGTA

Protein Information

Protein Name

paraxonemal rod protein PAR2

NCBI Protein GI

71398801

Protein Accession

XP_802646

Protein pI

6.21

Protein Weight

29966.04

Protein Length

264

Protein Sequence

>XP_802646.1 paraxonemal rod protein PAR2, partial [Trypanosoma cruzi strain CL Brener]
QDEAWRRIQELERVLQRLGTERFEEVKRRIEENDREEKRKVEYQQFLDVCGQHKKLLELSVYNCDLAMRC
IGMMEELVAEGCSAIKSRHDKTNEELGDLRLQVHQEYLEAFRRLYKTLGQLVYKKEKRLEEIDRNIRTTH
IQLEFAIETFDPNAKKHSDAKKELYKLRAQVEEELEMLKDKMAQALEMFGPTEDALNQAGIEFVHPAEEV
EDGNLTRRSKMVEYRAHLAKQEEVKIAAEREELKRSKTLQSQQYRGKTVQQITQ

Epitope Information

IEDB Linear Epitope