VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

765

Sequence Strain (Species/Organism)

Influenza A virus (A/equine/Kentucky/1/1981(H3N8))

VO ID

VO_0011302

Taxonomy ID

475467

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Skin and mucosal vaccination of ponies with HA from influenza virus A/equine/Ky/1/81 provided complete protection from clinical signs of infection after challenge, while skin vaccination provided partial protection; DNA vaccination provided partial protection from viral shedding (Lunn et al., 1999).

Related Vaccines(s)

Influenza virus DNA vaccine BacPAKHA encoding EqfKY HA , Influenza virus DNA vaccine encoding HA from Influenza A virus (A/equine/Kentucky/1/1981(H3N8))

References

Lunn et al., 1999: Lunn DP, Soboll G, Schram BR, Quass J, McGregor MW, Drape RJ, Macklin MD, McCabe DE, Swain WF, Olsen CW. Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine. 1999; 17(18); 2245-2258. [PubMed: 10403592].

Gene Information

Gene Name

NCBI Nucleotide GI

166079523

DNA Sequence

>gi|166079523|gb|CY028828.1| Influenza A virus (A/equine/Kentucky/1/1981(H3N8)) segment 4, complete sequence
TCTGTCAATCATGAAGACAACCATTATTTTGATACTACTGACCCATTGGGTCTACAGTCAAAACCCAACC
AGTGGCAACAACACAGCCACACTATGTCTGGGACACCATGCAGTAGCAAATGGAACATTGGTAAAAACAA
TAACTGATGACCAAATTGAGGTGACAAATGCTACTGAATTAGTTCAGAGCACTTCAATAGGGAAAATATG
CAACAACCCATATAGGGTTCTAGATGGAAGAAACTGCACATTAATAGATGCAATGCTAGGAGATCCCCAC
TGTGATGTTTTTCAGTATGAGAATTGGGACCTCTTCATAGAAAGAAGCAGCGCTTTCAGCAATTGCTACC
CATATGACATCCCTGACTATGCATCGCTCCGGTCTATTGTGGCATCTTCAGGAACATTAGAATTCACAGC
AGAGGGATTCACATGGACAGGTGTCACTCAAAACGGAAGAAGTGGAGCCTGCAGAAGGGGGTCAGCCGAT
AGTTTCTTTAGCCGACTGAATTGGCTAACAAAATCTGGAAATTCTTACCCCACATTGAATGTAACAATGC
CTAACAATAACAATTTCGATAAACTATACATCTGGGGGATCCATCACCCGAGCACAAACAATGAGCAGAC
AAAATTGTATATCCAAGAATCAGGGCGAGTAACAGTCTCAACAAAAAGAAGTCAACAAACAATAATCCCC
AACATCGGATCTAGACCGTGGGTCAGGGGTCAATCAGGCAGGATAAGCATATATTGGACCATTGTGAAAC
CTGGAGATATCCTAATGATAAACAGTAATGGCAACTTAGTTGCACCGCGGGGATATTTTAAAATGCGAAC
AGGGAAAAGCTCTGTAATGAGATCAGATGCACCCATAGACACTTGTGTGTCCGAGTGTATTACACCAAAT
GGAAGCATCCCCAACGACAAACCATTTCAAAATGTGAACAAAGTTACATATGGAAAATGCCCCAAGTATA
TCAAGCAGAATACTTTGAAGCTGGCCACTGGGATGAGGAATGTACCAGAAAAGCAAATCAGAGGAATCTT
TGGAGCAATAGCGGGATTCATAGAAAACGGCTGGGAAGGAATGGTTGATGGGTGGTATGGATTCCGATAT
CAGAATTCGGAAGGAACAGGACAAGCTGCAGATCTAAAGAGCACTCAAGCAGCCATCGACCAGATCAATG
GAAAATTGAACAGAGTGATTGAAAGGACCAATGAGAAATTCCATCAAATAGAGAAGGAATTCTCAGAAGT
AGAAGGGAGAATCCAGGACTTGGAGAAGTATGTAGAAGACACCAAAATAGACCTATGGTCCTACAATGCA
GAGTTACTGGTGGCTCTAGAAAATCAACATACGATTGACTTAACAGATGCAGAAATGAATAAATTATTCG
AGAAGACTAGGCGCCAGTTAAGAGAAAACGCGGAAGACATGGGGGGTGGATGTTTCAAGATTTATCACAA
ATGTGATAATGCATGCATTGGATCAATAAGAAATGGGACATATGACCATTACATATACAGAGATGAAGCA
TTAAACAACCGATTTCAAATTAAAGGTGTTGAATTGAAATCAGGCTACAAAGATTGGATACTGTGGATTT
CATTCGCCATATCATGCTTCTTAATTTGCGTTGTTCTATTGGGTTTCATCATGTGGGCTTGCCAAAAAGG
CAACATCAGATGCAACATTTGCATTTGAGTAAACTGATAGTTAAA

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

166079524

Protein Accession

ABY81481.1

Protein pI

7.98

Protein Weight

61820.7

Protein Length

654

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>ABY81481.1 hemagglutinin [Influenza A virus (A/equine/Kentucky/1/1981(H3N8))]
MKTTIILILLTHWVYSQNPTSGNNTATLCLGHHAVANGTLVKTITDDQIEVTNATELVQSTSIGKICNNP
YRVLDGRNCTLIDAMLGDPHCDVFQYENWDLFIERSSAFSNCYPYDIPDYASLRSIVASSGTLEFTAEGF
TWTGVTQNGRSGACRRGSADSFFSRLNWLTKSGNSYPTLNVTMPNNNNFDKLYIWGIHHPSTNNEQTKLY
IQESGRVTVSTKRSQQTIIPNIGSRPWVRGQSGRISIYWTIVKPGDILMINSNGNLVAPRGYFKMRTGKS
SVMRSDAPIDTCVSECITPNGSIPNDKPFQNVNKVTYGKCPKYIKQNTLKLATGMRNVPEKQIRGIFGAI
AGFIENGWEGMVDGWYGFRYQNSEGTGQAADLKSTQAAIDQINGKLNRVIERTNEKFHQIEKEFSEVEGR
IQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDAEMNKLFEKTRRQLRENAEDMGGGCFKIYHKCDN
ACIGSIRNGTYDHYIYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLICVVLLGFIMWACQKGNIR
CNICI

Epitope Information

IEDB Linear Epitope