VIOLIN: Vaccine Investigation and Online Information Network

MOMP

General Information

Protegen ID

767

Sequence Strain (Species/Organism)

Chlamydophila psittaci 89/1051

VO ID

VO_0010925

Taxonomy ID

83554

Other Database IDs

CDD:279628

Molecule Role

Protective antigen

Molecule Role Annotation

Plasmid DNA (pcDNA1::MOMP A) expressing the major outer membrane protein (MOMP) of Chlamydophila psittaci genotype A strain 89/1051 has been tested for its ability to induce protective immunity against Cp. psittaci challenge in budgerigars. DNA immunisation significantly reduced clinical signs, macroscopic lesions, pharyngeal and cloacal excretion as well as chlamydial replication, even in the presence of pre-existing serum antibodies, as compared to the placebo-vaccinated controls (Harkinezhad et al., 2009).

References

Harkinezhad et al., 2009: Harkinezhad T, Schautteet K, Vanrompay D. Protection of budgerigars (Melopsittacus undulatus) against Chlamydophila psittaci challenge by DNA vaccination. Veterinary research. 2009; 40(6); 61. [PubMed: 19640395].

Gene Information

Gene Name

MOMP

NCBI Nucleotide GI

144544

DNA Sequence

>gi|144544|gb|L04980.1|CHTMOMPXX Chlamydia psittaci major outer membrane protein (MOMP) gene, complete cds
CAATATAAGAAAGCCTTTACACTCTTCTACGAGGGTAATTCCAACTTATTCTAAGTGGCTAAGAAATAAA
AATGTGTACAAAAATCTGATATCTTTTATTAGCAAGTATAAGGAGTTATTTTGAAATCTATGCCTGAAAA
CAGTCTTTTTTCTTATCGTCTTTACTATAATAAGAAAAGTTTGTTATGTTTTCGAATAATGAACTGTATG
TTCATGCTTAAGGCTGTTTTCACTTGCAAGACACTCCTCAAAGCCATTAATTGCCTACAGGATATCTTGT
CTGGCTTTAACTTGGACGTGGTGCCGCCAGAAGAGCAAATTAGAATAGCGAGCACAAAAAGAAAAGATAC
TAAGCATAATCTTTAGAGGTGAGTATGAAAAAACTCTTGAAATCGGCATTATTGTTTGCCGCTACGGGTT
CCGCTCTCTCCTTACAAGCCTTGCCTGTAGGGAACCCAGCTGAACCAAGTTTATTAATCGATGGCACTAT
GTGGGAAGGTGCTTCAGGAGATCCTTGCGATCCTTGCGCTACTTGGTGTGACGCCATTAGCATCCGCGCA
GGATACTACGGAGATTATGTTTTCGATCGTGTATTAAAAGTTGATGTGAATAAAACTTTTAGCGGCATGG
CTGCAACTCCTACGCAGGCTACAGGTAACGCAAGTAATACTAATCAGCCAGAAGCAAATGGCAGACCGAA
CATCGCTTACGGAAGGCATATGCAAGATGCAGAGTGGTTTTCAAATGCAGCCTTCCTAGCCTTAAACATT
TGGGATCGCTTCGACATTTTCTGCACCTTAGGGGCATCCAATGGATACTTCAAATCAAGTTCGGCTGCAT
TCAACTTGGTTGGGTTAATAGGGTTTTCAGCTACCAGCTCAACCTCTACCGAGCTTCCAATGCAACTTCC
TAACGTAGGCATTACCCAAGGTGTTGTGGAATTTTATACAGACACATCATTTTCTTGGAGCGTAGGTGCA
CGTGGAGCTTTATGGGAATGTGGTTGTGCAACTTTAGGAGCTGAGTTCCAATACGCTCAATCTAATCCTA
AGATTGAAGTGCTCAACGTCACTTCAAGCCCAGCACAATTTGTGATTCACAAACCAAGAGGCTATAAAGG
AGCTAGCTCGAATTTTCCTTTACCTATAACGGCTGGAACAACAGAAGCTACAGACACCAAATCAGCTACA
ATTAAATACCATGAATGGCAAGTAGGCCTCGCCCTGTCTTACAGATTGAATATGCTTGTTCCATATATTG
GCGTAAACTGGTCAAGAGCAACTTTTGATGCTGATACTATCCGCATTGCTCAACCTAAATTAAAATCGGA
GATTCTTAACATTACTACATGGAACCCAAGCCTTCTAGGATCAACCACTGCTTTGCCCAATAATGCTGGT
AAGGATGTTCTATCTGATGTCTTGCAAATTGCTTCGATTCAGATCAACAAAATGAAGTCTAGAAAAGCTT
GTGGTGTAGCTGTTGGTGCAACGTTAATCGACGCTGACAAATGGTCAATCACTGGTGAAGCACGCTTAAT
CAATGAAAGAGCTGCTCACATGAATGCTCAATTCAGATTCTAAGGATTTAGTTTATACTATCCTAACTTT

Protein Information

Protein Name

major outer membrane protein

NCBI Protein GI

144545

Protein Accession

AAA17396.1

Protein pI

7.31

Protein Weight

41591.51

Protein Length

471

Protein Note

Chlamydia major outer membrane protein; pfam01308

Protein Sequence

>AAA17396.1 major outer membrane protein [Chlamydia psittaci]
MKKLLKSALLFAATGSALSLQALPVGNPAEPSLLIDGTMWEGASGDPCDPCATWCDAISIRAGYYGDYVF
DRVLKVDVNKTFSGMAATPTQATGNASNTNQPEANGRPNIAYGRHMQDAEWFSNAAFLALNIWDRFDIFC
TLGASNGYFKSSSAAFNLVGLIGFSATSSTSTELPMQLPNVGITQGVVEFYTDTSFSWSVGARGALWECG
CATLGAEFQYAQSNPKIEVLNVTSSPAQFVIHKPRGYKGASSNFPLPITAGTTEATDTKSATIKYHEWQV
GLALSYRLNMLVPYIGVNWSRATFDADTIRIAQPKLKSEILNITTWNPSLLGSTTALPNNAGKDVLSDVL
QIASIQINKMKSRKACGVAVGATLIDADKWSITGEARLINERAAHMNAQFRF

Epitope Information

IEDB Linear Epitope