VIOLIN: Vaccine Investigation and Online Information Network

fliC

General Information

Protegen ID

770

VO ID

VO_0011303

Taxonomy ID

884204

Other Database IDs

CDD:236344

Molecule Role

Protective antigen

Molecule Role Annotation

Flagellin encoding plasmid DNA was injected into Balb/c mice intramuscularly and this elicited both a humoral and a cellular immune response. Subsequent intravenous challenge of the vaccinated Balb/c mice with 10^5CFU of B. pseudomallei resulted in the number of bacterial cells detected in liver and/or spleen being significantly reduced in the flagellin plasmid DNA vaccinated mice. At 7 days subsequent to infection of B. pseudomallei, 5/6 (83%) of flagellin plasmid DNA vaccinated mice had survived (Chen et al., 2006).

Related Vaccines(s)

B. pseudomallei DNA vaccine encoding Flagellin Protein

References

Chen et al., 2006: Chen YS, Hsiao YS, Lin HH, Yen CM, Chen SC, Chen YL. Immunogenicity and anti-Burkholderia pseudomallei activity in Balb/c mice immunized with plasmid DNA encoding flagellin. Vaccine. 2006; 24(6); 750-758. [PubMed: 16169637].

Gene Information

Gene Name

fliC

Protein Information

Protein Name

flagellin

NCBI Protein GI

1929918

Protein pI

4.84

Protein Weight

37016.41

Protein Length

451

Protein Note

flagellin; Reviewed

Protein Sequence

>AAB51476.1 flagellin [Burkholderia pseudomallei 1026b]
MLGINSNINSLVAQQNLNGSQGALSQAITRLSSGKRINSAADDAAGLAIATRMQTQINGLNQGVSNANDG
VSILQTASSGLTSLTNSLQRIRQLAVQASNGPLSASDASALQQEVAQQISEVNRIASQTNYNGKNILDGS
AGTLSFQVGANVGQTVSVDLTQSMSAAKIGGGMVQTGQTLGTIKVAIDSSGAAWSSGSTGQETTQINVVS
DGKGGFTFTDQNNQALSSTAVTAVFGSSTAGTGTAASPSFQTLALSTSATSALSATDQANATAMVAQINA
VNKPQTVSNLDISTQTGAYQAMVSIDNALATVNNLQATLGAAQNRFTAIATTQQAGSNNLAQAQSQIQSA
DFAQETANLSRAQVLQQAGISVLAQANSLPQQVLKLLQ

Epitope Information

IEDB Linear Epitope