VIOLIN: Vaccine Investigation and Online Information Network

MOMP from C. psittaci 6BC

General Information

Protegen ID

771

Sequence Strain (Species/Organism)

Chlamydia psittaci 6BC

VO ID

VO_0011304

Taxonomy ID

331636

Other Database IDs

CDD:279628
GOA:Q46203
InterPro: IPR000604
UniProtKB/UniProt: Q46203

Molecule Role

Protective antigen

Molecule Role Annotation

Transgenic rice immunization expressing the Chlamydophila psittaci (Cp. psittaci) antigen (MOMP) fused to the B subunit of Escherichia coli heat-labile enterotoxin (LTB) induced partial protection (53.3%) against a lethal challenge with the highly virulent Cp. psittaci 6BC strain in a BALB/c mouse model (Zhang et al., 2009).

References

Zhang et al., 2009: Zhang X, Yuan Z, Duan Q, Zhu H, Yu H, Wang Q. Mucosal immunity in mice induced by orally administered transgenic rice. Vaccine. 2009; 27(10); 1596-1600. [PubMed: 19146896].

Gene Information

Gene Name

MOMP from C. psittaci 6BC

NCBI Nucleotide GI

40568

DNA Sequence

>gi|40568|emb|X56980.1| Chlamydia psittaci 6BC gene for major outer membrane protein (MOMP)
TTACACTCTTCTACGAGGGTAATTCCAACTTATTCTAAGTGGCATAAGAAATAAAAATGTGTACAAAAAT
CTGATAGCTCTTTTATTAGCAAGTATAAGGAGTTATTGCTTGAAATCTATGCCTGAAAACAGTCTTTTTT
CTTATCGTCTTTACTATAATAAGAAAAGTTTGTTATGTTTTCGAATAATGAACTGTATGTTCATGCTTAA
GGCTGTTTTCACTTGCAAGACACTCCTCAAAGCCATTAATTGCCTACAGGATATCTTGTCTGGCTTTAAC
TTGGACGTGGTGCCGCCAGAAGAGCAAATTAGAATAGCGAGCACAAAAAGAAAAGATACTAAGCATAATC
TTTAGAGGTGAGTATGAAAAAACTCTTGAAATCGGCATTATTGTTTGCCGCTACGGGTTCCGCTCTCTCC
TTACAAGCCTTGCCTGTAGGGAACCCAGCTGAACCAAGTTTATTAATCGATGGCACTATGTGGGAAGGTG
CTTCAGGAGATCCTTGCGATCCTTGCGCTACTTGGTGTGACGCCATTAGCATCCGCGCAGGATACTACGG
AGATTATGTTTTCGATCGTGTATTAAAAGTTGATGTGAATAAAACTTTTAGCGGCATGGCTGCAACTCCT
ACGCAGGCTACAGGTAACGCAAGTAATACTAATCAGCCAGAAGCAAATGGCAGACCGAACATCGCTTACG
GAAGGCATATGCAAGATGCAGAGTGGTTTTCAAATGCAGCCTTCCTAGCCTTAAACATTTGGGATCGCTT
CGACATTTTCTGCACCTTAGGGGCATCCAATGGATACTTCAAAGCAAGTTCGGCTGCATTCAACTTGGTT
GGGTTAATAGGGTTTTCAGCTGCAAGCTCAATCTCTACCGATCTTCCAATGCAACTTCCTAACGTAGGCA
TTACCCAAGGTGTTGTGGAATTTTATACAGACACATCATTTTCTTGGAGCGTAGGTGCACGTGGAGCTTT
ATGGGAATGTGGTTGTGCAACTTTAGGAGCTGAGTTCCAATACGCTCAATCTAATCCTAAGATTGAAATG
CTCAACGTCACTTCAAGCCCAGCACAATTTGTGATTCACAAACCAAGAGGCTATAAAGGAGCTAGCTCGA
ATTTTCCTTTACCTATAACGGCTGGAACAACAGAAGCTACAGACACCAAATCAGCTACAATTAAATACCA
TGAATGGCAAGTAGGCCTCGCCCTGTCTTACAGATTGAATATGCTTGTTCCATATATTGGCGTAAACTGG
TCAAGAGCAACTTTTGATGCTGATACTATCCGCATTGCTCAACCTAAATTAAAATCGGAGATTCTTAACA
TTACTACATGGAACCCAAGCCTTATAGGATCAACCACTGCTTTGCCCAATAATAGTGGTAAGGATGTTCT
ATCTGATGTCTTGCAAATTGCTTCGATTCAGATCAACAAAATGAAGTCTAGAAAAGCTTGTGGTGTAGCT
GTTGGTGCAACGTTAATCGACGCTGACAAATGGTCAATCACTGGTGAAGCACGCTTAATCAATGAAAGAG
CTGCTCACATGAATGCTCAATTCAGATTCTAAGGATTTAGTTTATACTATCCTAACTTTTTAAACCGCTA
TCAGAACCTGGGAGTCTCCGGGTTCTGATTTTTTAAATACCACCCTTTTC

Protein Information

Protein Name

major outer membrane protein

NCBI Protein GI

40569

Protein Accession

CAA40300.1

Protein pI

7.26

Protein Weight

41825.82

Protein Length

475

Protein Note

Chlamydia major outer membrane protein; pfam01308

Protein Sequence

>CAA40300.1 major outer membrane protein [Chlamydia psittaci 6BC]
MKKLLKSALLFAATGSALSLQALPVGNPAEPSLLIDGTMWEGASGDPCDPCATWCDAISIRAGYYGDYVF
DRVLKVDVNKTFSGMAATPTQATGNASNTNQPEANGRPNIAYGRHMQDAEWFSNAAFLALNIWDRFDIFC
TLGASNGYFKASSAAFNLVGLIGFSAASSISTDLPMQLPNVGITQGVVEFYTDTSFSWSVGARGALWECG
CATLGAEFQYAQSNPKIEMLNVTSSPAQFVIHKPRGYKGASSNFPLPITAGTTEATDTKSATIKYHEWQV
GLALSYRLNMLVPYIGVNWSRATFDADTIRIAQPKLKSEILNITTWNPSLIGSTTALPNNSGKDVLSDVL
QIASIQINKMKSRKACGVAVGATLIDADKWSITGEARLINERAAHMNAQFRF

Epitope Information

IEDB Linear Epitope