VIOLIN: Vaccine Investigation and Online Information Network

CP23

General Information

Protegen ID

776

Sequence Strain (Species/Organism)

Cryptosporidium parvum

VO ID

VO_0011308

Taxonomy ID

5807

Molecule Role

Protective antigen

Molecule Role Annotation

In this study, Cp23 antigen was investigated as a vaccine candidate using the DNA vaccine model in adult interleukin-12 (IL-12) knockout (KO) mice, which are susceptible to C. parvum infection. Cp23-DNA vaccination induced a 50-60% reduction in oocysts shedding, indicating a partial protection against C. parvum infection in IL-12 KO mice (Ehigiator et al., 2007).

Related Vaccines(s)

C. parvum DNA vaccine encoding CP23 , Cp15-23 , pVAX-15-23

References

Ehigiator et al., 2007: Ehigiator HN, Romagnoli P, Priest JW, Secor WE, Mead JR. Induction of murine immune responses by DNA encoding a 23-kDa antigen of Cryptosporidium parvum. Parasitology research. 2007; 101(4); 943-950. [PubMed: 17487508].

Gene Information

Gene Name

CP23

NCBI Gene ID

3372811

NCBI Nucleotide GI

U34390

Protein Information

Protein Name

Cp23 antigen

NCBI Protein GI

AAB17724.1

Protein pI

4.69

Protein Weight

11901.22

Protein Length

177

Protein Note

genotype: cervine

Protein Sequence

>AAB17724.1 protein with neutralization-sensitive epitopes [Cryptosporidium parvum]
MGCSSSKPETKVAENKSAADANKQRELAEKKAQLAKAVKNPAPISNQAQQKPEEPKKSEPAPNNPPAADA
PAAQAPAAPAEPAPQDKPADAPAAEAPAAEPAAQQDKPADA

Epitope Information

IEDB Linear Epitope