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CP15/60

General Information
Protegen ID 777
Sequence Strain (Species/Organism) Cryptosporidium parvum
VO ID VO_0011309
Taxonomy ID 5807
Molecule Role Protective antigen
Molecule Role Annotation Preparturient cows were immunized three times over a six-week period with recombinant plasmid DNA encoding the Cryptosporidium parvum CP15/60 antigen by injecting the DNA in the mammary gland. Colostrum from these cows contained Ab specific for C. parvum sporozoites and oocysts as indicated by immunofluorescence Ab (IFA) staining. Mice receiving immune colostrum showed partial protection (about 50% reduction) against intestinal C. parvum development compared to mice receiving control colostrum. This protection was evident at a challenge dose of 10^3 C. parvum oocysts per mouse (Jenkins et al., 1999).
Related Vaccines(s) C. parvum DNA vaccine encoding CP15/60
References
Jenkins et al., 1999: Jenkins MC, O'Brien C, Trout J, Guidry A, Fayer R. Hyperimmune bovine colostrum specific for recombinant Cryptosporidium parvum antigen confers partial protection against cryptosporidiosis in immunosuppressed adult mice. Vaccine. 1999; 17(19); 2453-2460. [PubMed: 10392628].
Gene Information
Gene Name CP15/60
NCBI Gene ID 3371947
NCBI Nucleotide GI 170676501
DNA Sequence 
>gi|170676501|gb|EU532137.1| Cryptosporidium parvum sporozoite surface antigen CP15/60 mRNA, complete cds
ATGGGTAACTTGAAATCCTGTTGTTCTTTTGCCGATGAACACTCCCTAACCCCTACTCAACTAGTAGTTG
GAAATGGTTCAGGAGCTTCAGAAACTGCTTCCAACCACCCCCAAGAAGAAGTTAATGATATTAATACTTT
TAATGTAAAGTTAACAATGCAAGATAGAAGTAAGCTTGACTGTGAGGTAGTATTTGATAGCACAAGTATT
TCGCTTTCTGGAGATGGAAAATGCAGAAATATTGCTTTGGATGAAATCCACCAATTATTATATTCAAAGG
AAGAGCTCTCTAGAGTTGAAAGTAGTGCTGGAATCAGTGATTCCGACAATTGTGTTGCAATTCATCTCAA
AGAATCAGGAAACTGTATTCCCCTTTTCTTTAATAATTCGCAAGACAAAGAAAGATTTGTTGCAACAGCA
AACAAATTCAAACCAAACTTTAACTAAAACAGGAATTTCATTAATTCTGGATTTGTTTTTTCCAAACCCT
ATAAATAAAATCCAAATAGCTTTTCTTCAATAACAGGGAG
Protein Information
Protein Name sporozoite surface antigen CP15/60
NCBI Protein GI 170676502
Protein Accession ACB30404.1
Protein pI 4.64
Protein Weight 15777.88
Protein Length 224
Protein Sequence 
>ACB30404.1 sporozoite surface antigen CP15/60 [Cryptosporidium parvum]
MGNLKSCCSFADEHSLTPTQLVVGNGSGASETASNHPQEEVNDINTFNVKLTMQDRSKLDCEVVFDSTSI
SLSGDGKCRNIALDEIHQLLYSKEELSRVESSAGISDSDNCVAIHLKESGNCIPLFFNNSQDKERFVATA
NKFKPNFN
Epitope Information
IEDB Linear Epitope