VIOLIN: Vaccine Investigation and Online Information Network

NS1

General Information

Protegen ID

781

VO ID

VO_0011312

Taxonomy ID

11060

Other Database IDs

CDD:213897
CDD:279316
InterPro: IPR001157
UniProtKB/TrEMBL: Q06371

Molecule Role

Protective antigen

Molecule Role Annotation

The protective efficacy and immune responses of mice intramuscularly injected with plasmid encoding DEN-2 non-structural protein 1 (NS1) was evaluated. Intravenously challenged by lethal DEN-2, mice vaccinated with NS1-DNA exhibited a delay onset of paralysis, a marked decrease of morbidity, and a significant enhancement of survival (Wu et al., 2003).

Related Vaccines(s)

Dengue DNA Vaccine encoding NS1 Protein , Dengue Virus DNA Vaccine encoding NS1 , Dengue virus DNA vaccine pcTPANS1 encoding NS1 fused to the tissue plasminogen activator signal sequence

References

Wu et al., 2003: Wu SF, Liao CL, Lin YL, Yeh CT, Chen LK, Huang YF, Chou HY, Huang JL, Shaio MF, Sytwu HK. Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice. Vaccine. 2003; 21(25-26); 3919-3929. [PubMed: 12922127].

Gene Information

Gene Name

NS1

Protein Information

NCBI Protein GI

288848

Protein pI

7.2

Protein Weight

41028.15

Protein Length

429

Protein Note

flavivirus envelope glycoprotein E, stem/anchor domain; TIGR04240

Protein Sequence

>CAA78918.1 NS1, partial [Dengue virus 2]
MNSRSTSLSVSQVLVGIVTLYLGVMVQADSGCVVSWKNKELKCGSGIFVTDNVHTRTEQYKFQPESPSKL
ASAIQKAHEEGICGIRSVTRLENLMWKQITSELNHILSENEVKLTIMTGDIKGIMQVGKRSLRPQPTELR
YSWKTWGKAKMLSTELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLRLREKQDAFCDSK
LMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMVIPKNFAGPKS
QHNNRPGYHTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLR
YRGEDGCWYGMEIRPLKEKEENLVSSLVTA

Epitope Information

IEDB Linear Epitope