G glycoprotein
General Information
Protegen ID
782
Sequence Strain (Species/Organism)
Nipah henipavirus
VO ID
VO_0011313
Taxonomy ID
121791
Molecule Role
Protective antigen
Molecule Role Annotation
Hamsters were immunized subcutaneously with either 107 PFU of VV-NiV.G or VV-NiV.F expressing the G and F glycoproteins, respectively, or with the two combined. When the VV-NiV.G-vaccinated animals were challenged with Nipah virus 3 months after the last immunization (1,000 PFU/animal intraperitoneally), there was complete protection against mortality (Guillaume et al. , 2004 ).
Related Vaccines(s)
ALVAC-NiV-F
,
ALVAC-NiV-G
,
NIpah Virus G and F Proteins Subunit Vaccine
,
Nipah Virus Vaccine rVSVĪG-NiVBG
,
PHV02
,
rMV-Ed-G
References
Guillaume et al. , 2004: Guillaume V, Contamin H, Loth P, Georges-Courbot MC, Lefeuvre A, Marianneau P, Chua KB, Lam SK, Buckland R, Deubel V, Wild TF. Nipah virus: vaccination and passive protection studies in a hamster model. Journal of virology . 2004; 78(2); 834-840. [PubMed: 14694115 ].
Gene Information
Gene Name
G glycoprotein
NCBI Gene ID
920955
Genbank Accession
AF212302
Locus Tag
Nvgp5
Gene Starting Position
8709
Gene Ending Position
11254
DNA Sequence
>NC_002728.1:8709-11254 Nipah virus, complete genome
TAGGACCCAGGTCCATAACTCATTGGATACTTAACTGTATCTTTCTAAGCTATCACATATCAAAGGAGAG
ATTGAATGCTTTTTTGGAGATCTAGATCATTACTATATGTGTCTCCTATAATCACATCATAGGAGTGAAC
CATAATACACATCTTTGGGTAGGGGAAGGAAAGTATTGTTGACGTACTGATTGATCTGCTTGAGTCAAAT
AATCAGTCATAACAATTCAAGAAAATGCCGGCAGAAAACAAGAAAGTTAGATTCGAAAATACTACTTCAG
ACAAAGGGAAAATTCCTAGTAAAGTTATTAAGAGCTACTACGGAACCATGGACATTAAGAAAATAAATGA
AGGATTATTGGACAGCAAAATATTAAGTGCTTTCAACACAGTAATAGCATTGCTTGGATCTATCGTGATC
ATAGTGATGAATATAATGATCATCCAAAATTACACAAGATCAACAGACAATCAGGCCGTGATCAAAGATG
CGTTGCAGGGTATCCAACAGCAGATCAAAGGGCTTGCTGACAAAATCGGCACAGAGATAGGGCCCAAAGT
ATCACTGATTGACACATCCAGTACCATTACTATCCCAGCTAACATTGGGCTGTTAGGTTCAAAGATCAGC
CAGTCGACTGCAAGTATAAATGAGAATGTGAATGAAAAATGCAAATTCACACTGCCTCCCTTGAAAATCC
ACGAATGTAACATTTCTTGTCCTAACCCACTCCCTTTTAGAGAGTATAGGCCACAGACAGAAGGGGTGAG
CAATCTAGTAGGATTACCTAATAATATTTGCCTGCAAAAGACATCTAATCAGATATTGAAGCCAAAGCTG
ATTTCATACACTTTACCCGTAGTCGGTCAAAGTGGTACCTGTATCACAGACCCATTGCTGGCTATGGACG
AGGGCTATTTTGCATATAGCCACCTGGAAAGAATCGGATCATGTTCAAGAGGGGTCTCCAAACAAAGAAT
AATAGGAGTTGGAGAGGTACTAGACAGAGGTGATGAAGTTCCTTCTTTATTTATGACCAATGTCTGGACC
CCACCAAATCCAAACACCGTTTACCACTGTAGTGCTGTATACAACAATGAATTCTATTATGTACTTTGTG
CAGTGTCAACTGTTGGAGACCCTATTCTGAATAGCACCTACTGGTCCGGATCTCTAATGATGACCCGTCT
AGCTGTGAAACCCAAGAGTAATGGTGGGGGTTACAATCAACATCAACTTGCCCTACGAAGTATCGAGAAA
GGGAGGTATGATAAAGTTATGCCGTATGGACCTTCAGGCATCAAACAGGGTGACACCCTGTATTTTCCTG
CTGTAGGATTTTTGGTCAGGACAGAGTTTAAATACAATGATTCAAATTGTCCCATCACGAAGTGTCAATA
CAGTAAACCTGAAAATTGCAGGCTATCTATGGGGATTAGACCAAACAGCCATTATATCCTTCGATCTGGA
CTATTAAAATACAATCTATCAGATGGGGAGAACCCCAAAGTTGTATTCATTGAAATATCTGATCAAAGAT
TATCTATTGGATCTCCTAGCAAAATCTATGATTCTTTGGGTCAACCTGTTTTCTACCAAGCGTCATTTTC
ATGGGATACTATGATTAAATTTGGAGATGTTCTAACAGTCAACCCTCTGGTTGTCAATTGGCGTAATAAC
ACGGTAATATCAAGACCCGGGCAATCACAATGCCCTAGATTCAATACATGTCCAGAGATCTGCTGGGAAG
GAGTTTATAATGATGCATTCCTAATTGACAGAATCAATTGGATAAGCGCGGGTGTATTCCTTGACAGCAA
TCAGACCGCAGAAAATCCTGTTTTTACTGTATTCAAAGATAATGAAATACTTTATAGGGCACAACTGGCT
TCTGAGGACACCAATGCACAAAAAACAATAACTAATTGTTTTCTCTTGAAGAATAAGATTTGGTGCATAT
CATTGGTTGAGATATATGACACAGGAGACAATGTCATAAGACCCAAACTATTCGCGGTTAAGATACCAGA
GCAATGTACATAAAAATCAACCTCATAATTTAATGGATTGATCTAATATAATGATAATAATCGTACAAAG
ACATGTGATGTAAACAAAATTGTTGTAATTAAATAAGTCCTCAGCTGAATACTTTTTTAAGATTAGCAAT
AGCATGTTTTTCCAGTTATTGGATAGTTGATAATATAATTCTGAAACTGGGTTAATAAATAATCTTGATC
GGTGATCTTTGAGAACAATGATATCATATAGTTCATCAAGTGATAATCAATTCTTTATATGTACACTTTA
GAGTATATTTTGAGACTTAGTATTTTCGGCCCGAATGTTAAATTTAATAGTTCATACATAACCTAAACTC
AAGTTCTAAGCATAATGATAACAATTAATGCGAACTTGTCTTGATGTAAGGAAGATTTGATATTAACTGA
GACTCCACTTGATATAGTAGAGCTGAATCTTGTAAATAAATTATAATGAATAGTTTATTCAAAGATTATC
ATTCATATTAGTGTAAATTAAGAAAA
Protein Information
Protein Name
attachment glycoprotein
NCBI Protein GI
13559814
Protein Accession
NP_112027
3D structure: PDB ID
2VWD
Protein pI
8.36
Protein Weight
62969.63
Protein Length
602
Protein Sequence
>NP_112027.1 attachment glycoprotein [Nipah henipavirus]
MPAENKKVRFENTTSDKGKIPSKVIKSYYGTMDIKKINEGLLDSKILSAFNTVIALLGSIVIIVMNIMII
QNYTRSTDNQAVIKDALQGIQQQIKGLADKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTASINE
NVNEKCKFTLPPLKIHECNISCPNPLPFREYRPQTEGVSNLVGLPNNICLQKTSNQILKPKLISYTLPVV
GQSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFMTNVWTPPNPNTVY
HCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKSNGGGYNQHQLALRSIEKGRYDKVMP
YGPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSD
GENPKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQ
SQCPRFNTCPEICWEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQK
TITNCFLLKNKIWCISLVEIYDTGDNVIRPKLFAVKIPEQCT
Vaxign Prediction
Localization(Probability)
Adhesin Probability 0.128
Trans-membrane Helices 1
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope
-- Assay Type --
T Cell Epitope
B Cell Epitope
IEDB ID
Epitope
MHC restriction
Starting position
Ending position
IEDB ID
Epitope
Starting position
Ending position
100351 NQILKPKLISYTLPVVG
195
212
MPAENKKVRFENTTSDKGKIPSKVIKSYYGTMDIKKINEGLLDSKILSAFNTVIALLGSIVIIVMNIMIIQNYTRSTDNQAVIKDALQGIQQQIKGLADKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTASINENVNEKCKFTLPPLKIHECNISCPNPLPFREYRPQTEGVSNLVGLPNNICLQKTSNQILKPKLISYTLPVVGQSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFMTNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKSNGGGYNQHQLALRSIEKGRYDKVMPYGPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGENPKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEICWEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDTGDNVIRPKLFAVKIPEQCT
