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F fusion protein

General Information
Protegen ID 783
Sequence Strain (Species/Organism) Nipah virus
VO ID VO_0011314
Taxonomy ID 121791
Other Database IDs CDD:306910
Molecule Role Protective antigen
Molecule Role Annotation Hamsters were immunized subcutaneously with either 10^7 PFU of VV-NiV.G or VV-NiV.F expressing the G and F glycoproteins, respectively, or with the two combined. When the VV-NiV.F-vaccinated animals were challenged with Nipah virus 3 months after the last immunization (1,000 PFU/animal intraperitoneally), there was complete protection against mortality (Guillaume et al., 2004).
Related Vaccines(s) ALVAC-NiV-F , ALVAC-NiV-G , NIpah Virus G and F Proteins Subunit Vaccine
References
Guillaume et al., 2004: Guillaume V, Contamin H, Loth P, Georges-Courbot MC, Lefeuvre A, Marianneau P, Chua KB, Lam SK, Buckland R, Deubel V, Wild TF. Nipah virus: vaccination and passive protection studies in a hamster model. Journal of virology. 2004; 78(2); 834-840. [PubMed: 14694115].
Gene Information
Gene Name F fusion protein
NCBI Nucleotide GI 8164021
DNA Sequence 
>gi|8164021|gb|AF238466.1| Nipah virus fusion protein mRNA, complete cds
AGGAGCCAAGCTCTTGCCTCGTTCAGAAGGTTAAACAAGCATTCTTACCATTGGATCAACAAAAGGATTG
GTTTTATCGTCTAAGAAATTTATTGAAAGGCAAAGAAATTCCTGGTTTTATGTTGAATGAGGTGTATCAA
ACTAAGGAGACCTTCTAACAGCCAGGTCATAGGAATATAAATAAAAATAAGAATAAAATTGATTCCATCG
GAAGATTCATTTCAAGAAGTGATCAAATCAAAGCGGTTGGCAGACCTACCAATCATATACCACAAGACTC
GACAATGGTAGTTATACTTGACAAGAGATGTTATTGTAATCTTTTAATATTGATTTTGATGATCTCGGAG
TGTAGTGTTGGGATTCTACATTATGAGAAATTGAGTAAAATTGGACTTGTCAAAGGAGTAACAAGAAAAT
ACAAGATTAAAAGCAATCCTCTCACAAAAGACATTGTTATAAAAATGATTCCGAATGTGTCGAACATGTC
TCAGTGCACAGGGAGTGTCATGGAAAATTATAAAACACGATTAAACGGTATCTTAACACCTATAAAGGGA
GCGTTAGAGATCTACAAAAACAACACTCATGACCTTGTCGGTGATGTGAGATTAGCCGGAGTTATAATGG
CAGGAGTTGCTATTGGGATTGCAACCGCAGCTCAAATCACTGCAGGTGTAGCACTATATGAGGCAATGAA
GAATGCTGACAACATCAACAAACTCAAAAGCAGCATTGAATCAACTAATGAAGCTGTCGTTAAACTTCAA
GAGACTGCAGAAAAGACAGTCTATGTGCTGACTGCTCTACAGGATTACATTAATACTAATTTAGTACCGA
CAATTGACAAGATAAGCTGCAAACAGACAGAACTCTCACTAGATCTGGCATTATCAAAGTACCTCTCTGA
TTTGCTTTTTGTATTTGGCCCCAACCTTCAAGACCCAGTTTCTAATTCAATGACTATACAGGCTATATCT
CAGGCATTCGGTGGAAATTATGAAACACTGCTAAGAACATTGGGTTACGCTACAGAAGACTTTGATGATC
TTCTAGAAAGTGACAGCATAACAGGTCAAATCATCTATGTTGATCTAAGTAGCTACTATATAATTGTCAG
GGTTTATTTTCCTATTCTGACTGAAATTCAACAGGCCTATATCCAAGAGTTGTTACCAGTGAGCTTCAAC
AATGATAATTCAGAATGGATCAGTATTGTCCCAAATTTCATATTGGTAAGGAATACATTAATATCAAATA
TAGAGATTGGATTTTGCCTAATTACAAAGAGGAGCGTGATCTGCAACCAAGATTATGCCACACCTATGAC
CAACAACATGAGAGAATGTTTAACGGGATCGACTGAGAAGTGTCCTCGAGAGCTGGTTGTTTCATCACAT
GTTCCCAGATTTGCACTATCTAACGGGGTTCTGTTTGCCAATTGCATAAGTGTTACATGTCAGTGTCAAA
CAACAGGCAGGGCAATCTCACAATCAGGAGAACAAACTCTGCTGATGATTGACAACACCACCTGTCCTAC
AGCCGTACTCGGTAATGTGATTATCAGCTTAGGGAAATATCTGGGGTCAGTAAATTATAATTCTGAAGGC
ATTGCTATCGGTCCTCCAGTCTTTACAGATAAAGTTGATATATCAAGTCAGATATCCAGCATGAATCAGT
CCTTACAACAGTCTAAGGACTATATCAAAGAGGCTCAACGACTCCTTGATACTGTTAATCCATCATTAAT
AAGCATGTTGTCTATGATCATACTGTATGTATTATCGATCGCATCGTTGTGTATAGGGTTGATTACATTT
ATCAGTTTTATCATTGTTGAGAAAAAGAGAAACACCTACAGCAGATTAGAGGATAGGAGAGTCAGACCTA
CAAGCAGTGGGGATCTCTACTACATTGGGACATAGTGTATTCAGATTGATGAAATTATGTTAGAGAAATC
AGAAAACTTCTGACTTTCAGAAATGGATTGTATACAATTAGTTAGATCATCCTGAATAATCGAGGTGAGA
ACATTGCAACTATAAAATCAGATCATGTAAATAGTTGTAAAAAATTAAAAGCTTCTTTTAATTCTTTTGA
ACAATAATTTAATTAATATATAACATATTCTCTCACACGAGCGCTAACCTATACACTCTCTACTAATATT
TTATACTCATAATTAATGATATAATGACAAATAAGGATTCAAATTGGATTATGATATAGTTTCATACTAC
AATAGCATTTCGACCAAGAAAATATCCTTACAATTATACAATGTACTTAACCGTGAATATGTAATTGATA
ATTTCCCTTTAGAAATTTAATAAAAAA
Protein Information
Protein Name fusion protein
NCBI Protein GI 8164022
Protein Accession AAF73956.1
Protein pI 5.9
Protein Weight 56616.49
Protein Length 602
Protein Note Fusion glycoprotein F0; pfam00523
Protein Sequence 
>AAF73956.1 fusion protein [Nipah henipavirus]
MVVILDKRCYCNLLILILMISECSVGILHYEKLSKIGLVKGVTRKYKIKSNPLTKDIVIKMIPNVSNMSQ
CTGSVMENYKTRLNGILTPIKGALEIYKNNTHDLVGDVRLAGVIMAGVAIGIATAAQITAGVALYEAMKN
ADNINKLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINTNLVPTIDKISCKQTELSLDLALSKYLSDL
LFVFGPNLQDPVSNSMTIQAISQAFGGNYETLLRTLGYATEDFDDLLESDSITGQIIYVDLSSYYIIVRV
YFPILTEIQQAYIQELLPVSFNNDNSEWISIVPNFILVRNTLISNIEIGFCLITKRSVICNQDYATPMTN
NMRECLTGSTEKCPRELVVSSHVPRFALSNGVLFANCISVTCQCQTTGRAISQSGEQTLLMIDNTTCPTA
VLGNVIISLGKYLGSVNYNSEGIAIGPPVFTDKVDISSQISSMNQSLQQSKDYIKEAQRLLDTVNPSLIS
MLSMIILYVLSIASLCIGLITFISFIIVEKKRNTYSRLEDRRVRPTSSGDLYYIGT
Vaxign Prediction
Localization(Probability)
(Prob.=0)
Adhesin Probability 0.233
Trans-membrane Helices 2
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope