VIOLIN: Vaccine Investigation and Online Information Network

prM from Dengue virus 4

General Information

Protegen ID

784

VO ID

VO_0011315

Taxonomy ID

11070

Other Database IDs

CDD:279856
CDD:279358

Molecule Role

Protective antigen

Molecule Role Annotation

A recombinant vaccinia virus that expressed the pre-M protein of Dengue 4 virus was constructed. Mice immunized with the recombinant virus were protected against subsequent dengue 4 encephalitis challenge (Bray and Lai, 1991).

Related Vaccines(s)

Dengue Vaccine using Vaccinia Virus expressing prM Protein , Dengue Virus DNA Vaccine expressing prM/E proteins , Dengvaxia , TAK-003

References

Bray and Lai, 1991: Bray M, Lai CJ. Dengue virus premembrane and membrane proteins elicit a protective immune response. Virology. 1991; 185(1); 505-508. [PubMed: 1926792].

Gene Information

Gene Name

prM from Dengue virus 4

Protein Information

Protein Name

premembrane

NCBI Protein GI

18308086

Protein Length

184

Protein Note

Flavivirus polyprotein propeptide; pfam01570

Protein Sequence

>AAL67829.1 premembrane, partial [Dengue virus 4]
FHLSTRDGEPLMIVAKHERGRPLLFKTTEGINKCTLIAMDLGEMCEDTVTYKCPLLVNTEPEDIDCWCNL
TSTWVMYGTCPQSGERRREKRSVALTPHSGMGLETRAETWMSSEGAWKHAQRVESWILRNP

Epitope Information

IEDB Linear Epitope